ID A0A093JIK0_FULGA Unreviewed; 1770 AA.
AC A0A093JIK0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
DE Flags: Fragment;
GN ORFNames=N327_11101 {ECO:0000313|EMBL:KFW11677.1};
OS Fulmarus glacialis (Northern fulmar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Procellariiformes; Procellariidae;
OC Fulmarus.
OX NCBI_TaxID=30455 {ECO:0000313|EMBL:KFW11677.1, ECO:0000313|Proteomes:UP000053806};
RN [1] {ECO:0000313|EMBL:KFW11677.1, ECO:0000313|Proteomes:UP000053806}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N327 {ECO:0000313|EMBL:KFW11677.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR EMBL; KK610249; KFW11677.1; -; Genomic_DNA.
DR Proteomes; UP000053806; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14625; R-PTPc-S-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 7.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:KFW11677.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053806};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1244..1267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..92
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 104..193
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 201..283
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 290..380
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 385..479
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 483..572
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 577..674
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 679..778
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 779..872
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 877..973
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1334..1589
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1509..1580
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1621..1770
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW11677.1"
FT NON_TER 1770
FT /evidence="ECO:0000313|EMBL:KFW11677.1"
SQ SEQUENCE 1770 AA; 198015 MW; C04900EEA92DB350 CRC64;
PPVFIKKPVD QIGVSGGVAS FVCQATGDPK PRVTWNKKGK KVNSQRFETI EFDESAGAVL
RIQPLRTPRD ENIYECVAQN PHGEVTVHAK LTVLREDQLP PGFPNIDMGP QLKVVERTRT
ATMLCAASGN PDPEITWFKD FLPVDPSASN GRIKQLRSGG LQIESSEETD QGKYECVASN
SAGVRYSSPA NLYVRVRRVA PRFSILPVSH EIMPGGNVNI TCVAVGSPMP YVKWMQGAED
LTPEDDMPVG RNVLELTDVK DSANYTCVAM SSLGVIEAVA QITVKSLPKA PGTPVVTETT
ATSITITWDS GNPDPVSYYV IEYKSKSQDG PYQIKEDITT TRYSIGGLSP NSEYEIWVSA
VNSIGQGPPS ESVVTRTGEQ APASAPRNVQ GRMLSSTTMI IQWEEPVEPN GQIRGYRVYY
TMEPDQPVSN WQKHNVDDSL LTTVGSLLED ETYTVRVLAF TSVGDGPLSD PIQVKTQQGV
PGQPMNFRAE AKTETSIVLS WSPPRQEIIV KYELLYKEGD HGREVPKNFE PTTSFTVEGL
KPNTEYVFRL AARSALGLGA FTPEVRERTL QSKPSAPPQD VKCVSTRSTA ILVSWRPPPA
ESQNGVLAGY SVYYRALDSE DTELKEVNDI PPSTSQILLE SLEKWTEYRI TVVAHTEVGP
GPESSPVIVR TDEDVPSAPP RKVEVEVLNS TAIQVFWRSP VQNRQHGQIR GYQVHYVRME
NGEARGLPQI KDVMLADAQE MIIAGLQPET AYSITVAAYT MKGDGARSKP KVVTTKGAVP
GKPILSVHQT EENTLLVKWE PPLDAEGQVM GYRLQFGRKD VDPLATLEFT ALEDKYTAPS
IHKGATYVFK LAVKSRAGFG EEAVQELTTP EDIPKGYPQI LEASNITSMS VQFGWLPPVL
AERNGAIVKY TVAYREAGSP GNPLEKDLPP SPENSYTLNG LKPNTAYDVK IRAHTSKGPG
PYSPTVQYRT FQLDQVLPKN FKVKMVTKTS VLLSWEFPEN YNSPTPYKAS GREHLAHGTT
SLLVRLPQIQ YNGLNVDVDG RTTKKLITNL KPRTFYNFVL MNRGNSMGGL QQNVAAWTAA
DMLSKKPEVT HKPDADGNVV VILPDVKSSV PVQAYYIVVV PLRKSRGGQF LNPLGSPEEM
DLEELVQDIA RLRRRSLRHS RQLDFPKPYI AARFRSLPSH FILGDMKHYD NFENRALEPG
QKYVIFILAV LQEPEATFAA SPFSDPIQLD NPDPQPIIDG EEGLIWVIGP VLAVVFIICI
VIAILLYKNK RKDSEPRTKC LLNNAEITPH HPKDPVEMRR INFQTPGMLS HPPIPVSELA
EHTEHLKAND NLKLSQEYES IDPGQQFTWE HSNLEVNKPK NRYANVIAYD HSRVILLPIE
GIVGSDYINA NYIDGYRKQN AYIATQGPLP ETFGDFWRMV WEQRSATIVM MTKLEEKSRI
KCDQYWPGRG TDTYGMIQVT LLDTIELATF CVRTFSLHKN GSSEKREVRQ FQFTAWPDHG
VPEYPTPFLA FLRRVKTCNP PDAGPIVVHC SAGVGRTGCF IVIDAMLERI KHEKTVDIYG
HVTLMRSQRN YMVQTEDQYS FIHDALLEAV ACGNTEVPAR NLYTYIQKLA QIEVGEHVTG
MELEFKRLAN SKAHTSRFIS ANLPCNKFKN RLVNIMPYET TRVCLQPIRG VEGSDYINAS
FIDGYRQQKA YIATQGPLAE TTEDFWRMLW ENNSTIVVML TKLREMGREK CHQYWPAERS
ARYQYFVVDP MAEYNMPQYI LREFKVTDAR
//
