ID A0A093QBU4_9PASS Unreviewed; 624 AA.
AC A0A093QBU4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=NAD(+) hydrolase SARM1 {ECO:0000256|ARBA:ARBA00024128};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
DE AltName: Full=NADP(+) hydrolase SARM1 {ECO:0000256|ARBA:ARBA00032222};
DE AltName: Full=Sterile alpha and TIR motif-containing protein 1 {ECO:0000256|ARBA:ARBA00031160};
DE Flags: Fragment;
GN ORFNames=N305_15094 {ECO:0000313|EMBL:KFW86443.1};
OS Manacus vitellinus (golden-collared manakin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW86443.1, ECO:0000313|Proteomes:UP000053258};
RN [1] {ECO:0000313|EMBL:KFW86443.1, ECO:0000313|Proteomes:UP000053258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW86443.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NADP(+) = ADP-D-ribose 2'-phosphate + H(+) +
CC nicotinamide; Xref=Rhea:RHEA:19849, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:58673; Evidence={ECO:0000256|ARBA:ARBA00023911};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19850;
CC Evidence={ECO:0000256|ARBA:ARBA00023911};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) = cyclic ADP-beta-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:38611, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:73672;
CC Evidence={ECO:0000256|ARBA:ARBA00034259};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38612;
CC Evidence={ECO:0000256|ARBA:ARBA00034259};
CC -!- SIMILARITY: Belongs to the SARM1 family.
CC {ECO:0000256|ARBA:ARBA00008291}.
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DR EMBL; KL672574; KFW86443.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093QBU4; -.
DR STRING; 328815.ENSMVIP00005015197; -.
DR Proteomes; UP000053258; Unassembled WGS sequence.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0019677; P:NAD catabolic process; IEA:UniProt.
DR GO; GO:0034128; P:negative regulation of MyD88-independent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048678; P:response to axon injury; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09501; SAM_SARM1-like_repeat1; 1.
DR CDD; cd09502; SAM_SARM1-like_repeat2; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR039184; SARM1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR22998:SF1; NAD(+) HYDROLASE SARM1; 1.
DR PANTHER; PTHR22998; SARM1; 1.
DR Pfam; PF07647; SAM_2; 2.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunity {ECO:0000256|ARBA:ARBA00022588};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000053258};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 317..381
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 462..605
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW86443.1"
FT NON_TER 624
FT /evidence="ECO:0000313|EMBL:KFW86443.1"
SQ SEQUENCE 624 AA; 70678 MW; 67D5A333648324DC CRC64;
FRLVEEAWGM PALGRDVAKV LCDVIRLEGG LDLLLNLLYT AELETKCQAG KLLEQILVAE
NRDRIARIGL GVILNLAKER DVPQLVQSVS GILEHMFKHT EETCFQLISD GGLDAILYWC
RWTDPIVLRH CAMALANCAM YGGQANQRLM IEKRAAEWLF PLVFSKDDEL IRLHACLAIT
VLATNKEIEK EVERSGTLAL VEPFIASLDP EQFAREMLGS SDNVQGRTAE DLQRLVPLLD
SSRLEAQCIA AFYLCTEAAI KTRQKKTQIF SEIGATQSLK RIVCYSTSST TSSLAKKVLR
MIGEEVPRRI LPTVPNWKSC EVQTWLQQIG FNKYCQRFLD HQVDGDILLR LTEKELQEDL
GMDSSITRKR FFRELTELKT FANYSTCDRS NLADWLGGID PKFRQYTYNL LTCGINRNFL
HRVTEQQLQE DCHIDTGFHR VRILTAARET LHSPITLQTT SNGTDVFISY RRSTGSQLAS
LLKVHLQLHG FSVFIDVEKL EAGKFEDKLI QSVMSARNFV LVLSPNALDK CMEDPECKDW
VHKEIVTALN SGKNIVPVTD HFEWPDPETL PKDMRAVLKF NGIKWSHEYQ EATIDKIIRF
LQGRSSRDSS AGSENGLDCL LSVG
//
