ID   A0A093QH57_PHACA        Unreviewed;       729 AA.
AC   A0A093QH57;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Seprase {ECO:0000313|EMBL:KFW88273.1};
DE   Flags: Fragment;
GN   ORFNames=N336_06924 {ECO:0000313|EMBL:KFW88273.1};
OS   Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Suliformes; Phalacrocoracidae;
OC   Phalacrocorax.
OX   NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW88273.1, ECO:0000313|Proteomes:UP000053238};
RN   [1] {ECO:0000313|EMBL:KFW88273.1, ECO:0000313|Proteomes:UP000053238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW88273.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC       Cell projection, invadopodium membrane {ECO:0000256|ARBA:ARBA00004341};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004341}.
CC       Cell projection, lamellipodium membrane
CC       {ECO:0000256|ARBA:ARBA00004485}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004485}.
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DR   EMBL; KL420195; KFW88273.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093QH57; -.
DR   MEROPS; S09.007; -.
DR   Proteomes; UP000053238; Unassembled WGS sequence.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008239; F:dipeptidyl-peptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF136; PROLYL ENDOPEPTIDASE FAP; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE   4: Predicted;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053238}.
FT   DOMAIN          75..441
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          523..726
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFW88273.1"
FT   NON_TER         729
FT                   /evidence="ECO:0000313|EMBL:KFW88273.1"
SQ   SEQUENCE   729 AA;  84296 MW;  DAFEE18F019AFE75 CRC64;
     VVNTDDHPRA LTLEDYLNGN FQYKTFFPYW VSDNEYLHQS AEDDIILYNV EMNYPTTIMT
     NSTMKQVNAS NYVLSSDKYF IALESNYSKL WRYSYTASYH IYDLIYRGFV TENQLPREIQ
     YISWSPVGHK LVYVYQNNIY LKQSPREAPI KITSDGKQNE IFNGIPDWVY EEEMLATKYA
     LWWSPSGKYL AYVQFNDSDI PVIEYSYFGE DQYPRKIIIP YPKAGAKNPT VKVFIVDTVN
     AEAFGPKEVP VPAVIASSDH YFTWLTWVTD SRICVQWLKR IQNFSVLAIC DFKENSNTWD
     CPESQQHIEE SQTGWAGGFF VSTPYFTSDS SSYYKIFSDK NGYKHIHYIN GSVENSIQIT
     SGEWEAIYIF RVTNDAIFYS SNEFEGYPGR RNIYKISIGS KPIRKQCITC NLRKERCQYY
     TARFSEHSKY YALICYGPGI PISTLFESHG DRELRVLEDN WELQSALQEI KLPKEEINKL
     EVDGITLWYK MLLPPQFDRS KKYPLLIQVY GGPCSQNVKE TFSISWITYL ASKEGIIVAL
     VDGRGTAYQG DKILHAVYRR LGVYEVEDQI SAVKKFIEMG FIDEKRIAIW GWSYGGYVTS
     LALGSGSGVF KCGMAVAPVS SWEYYASIYT ERFMGLPVES DNLEHYKNST VMARAKNFQN
     VEYLLIHGTA DDNVHFQNSA QIAKALVNAQ VDFQAMWYTD QNHGIPGLSR KHLYTHMTHF
     LKQCFSMSE
//