ID A0A093RHL4_PHACA Unreviewed; 1571 AA.
AC A0A093RHL4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 1 {ECO:0000256|ARBA:ARBA00020612, ECO:0000256|RuleBase:RU364059};
DE AltName: Full=Mediator complex subunit 1 {ECO:0000256|ARBA:ARBA00031254, ECO:0000256|RuleBase:RU364059};
DE Flags: Fragment;
GN ORFNames=N336_06719 {ECO:0000313|EMBL:KFW95462.1};
OS Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Suliformes; Phalacrocoracidae;
OC Phalacrocorax.
OX NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW95462.1, ECO:0000313|Proteomes:UP000053238};
RN [1] {ECO:0000313|EMBL:KFW95462.1, ECO:0000313|Proteomes:UP000053238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW95462.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364059}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364059}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC {ECO:0000256|ARBA:ARBA00006210, ECO:0000256|RuleBase:RU364059}.
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DR EMBL; KL446068; KFW95462.1; -; Genomic_DNA.
DR Proteomes; UP000053238; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR InterPro; IPR019680; Mediator_Med1.
DR PANTHER; PTHR12881; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1; 1.
DR PANTHER; PTHR12881:SF10; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1; 1.
DR Pfam; PF10744; Med1; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU364059};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364059};
KW Reference proteome {ECO:0000313|Proteomes:UP000053238};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364059};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364059}.
FT DOMAIN 52..418
FT /note="Mediator complex subunit Med1"
FT /evidence="ECO:0000259|Pfam:PF10744"
FT REGION 530..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..1559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..744
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..824
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1006
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1337..1354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1355..1376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1414..1472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1496..1520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1521..1545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW95462.1"
FT NON_TER 1571
FT /evidence="ECO:0000313|EMBL:KFW95462.1"
SQ SEQUENCE 1571 AA; 167077 MW; EDF06720C561A931 CRC64;
ETEKLNKMST LLERLHAKYN QNRPWTETMK LVRQVMEKRV VMNSGGHQHL VSCLETLQKA
LKVSSLPAMT DRLESIARQN GLGSHLSANG TECYITSDMF YVEVQLDPTG LLCDVKVAHH
GENPVSCPEL VQHLREKNFD EFSKHLRGLV NLYKLPGDNK LKTKMYLALQ SLELDLSKMA
GMYWQATNAN PLDKILHGSV GYLTPRSGGL LMNLKYYVSP YDLFEDGTGA PVILHESNVP
RSLGMNVSVT VEGTMAMYKL PIAPLIMGSH PVDSKGTPSF SSITSANSVD LPACFFLKFP
RPIPVSRPFI QKIQGCTGIP LFDTPPTFVP LYELITQFEL SKEADPLPLN HNMRFYAALP
GQQHCYFLNK DAPLPDGRSL QGTLISKIAF QHPGRVPLIL NLIRHQVAYN TLIGSCVKRT
VLKEDSPGIL QFEVCPLSDS CFSVSFQHPV NDSLVCVVMD VQDSTHVNCK LYKGLSDALI
CTDDFIAKVV QRCMSIPVTM RAIRRKAETI QADTPALSLI AETVEDMVKK NLPPASSPGY
GMTTGSNPMS GTTTPTNTFP GGPITTLFNM SISMKERHDS VGHGEDFSKV SQNPILTSLL
QITGNVGSTX XXXPHHTPPP VSSPASNTKN HPMLMNLLKE NPPQDFSTLY GSSPLERQNS
SSGSPRMEMG PGGNKQKKKK SRMPADKPKH QTEDDFQREL FSMDVDSQNP IFDVNMTADT
LDTPHITPAP SQCSTPPTTY PQPIPHSQPS IQRMVRLSSS DSIGADVTDI LSDIAEEASK
LPTTNEDCPP IGTPVRDSSS SGHSQSALFD PDVFQTNNSE NPYTDPADLI ADAAVSPNSD
SSNHFFPDGV DFNPDLLNSQ SQSGFGEEYF DESSQSGDTD DFKGYASQAL TTLGVQVLGA
DGGENKFKGS NPSDTVDFSI IAAASKALGS SDIMEHHSGG QSPLLNTGDL GKEKPQKRVK
EGNGSGSNMA GPGIDGKPGK RSGTPSSDGK SKEKLPKRKK QETDGKSPSH SSSNRPFTPP
ASTGGSKSPG SSGRSQTPPG VATPPIPKIT IQIPKGTVTV GKPSSHGQYT SSGSVTSSSS
KSHHSHSSSS SSSSSSSTSG KIKSSKSEGS SGSKMSSSLY SSQGGSSSGQ SKSSAQSVGK
PGSSPITKHG LSSGSGSTKM KPQGKPSSLM NPSMSKPNIS PSHSRPSGGS DKLASPMKPV
PGTPPSSKAK SPISSGSGGS HMSGTGSSSS MKSSSGMGSS GSMSQKPPPS SNSSTASSSS
FSSSGSSMSS SQNQHGSSKG KSPSRNKKPS LTAVIDKLKH GVVTSGPGGD DPMDGQMGPS
SNSSSHTMSS KHNMSGGEFQ GKREKSDKEK SKVSVSGGSV DSSKKTSDSK NVGSTGVAKI
IISKHDGGSP SIKAKVTLQK PGEGGGDGLR PQMASSKSYG SPLISGSTPK HERCSPSHSK
SPAYTPQNID SESESGSSIA EKSYQNSPSS DDGIRPLPEY SSEKHKKHKK EKKKVKDKDR
DRDRDRDKDR DKKKSHSMKP ESWSKSPISA DQSLSMASSA ILSAERPSRP SPEFLIGEED
DDLMDVALIG N
//
