UniProt: A0A093S6C6

Database: UniProt
Entry: A0A093S6C6_9PASS

LinkDB:  A0A093S6C6_9PASS 
Original site:  A0A093S6C6_9PASS

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (4)   
   InterPro (2)   
   Pfam (1)   
   PROSITE (1)   
All databases (10)   

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ID   A0A093S6C6_9PASS        Unreviewed;       541 AA.
AC   A0A093S6C6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=tRNA (uracil-O(2)-)-methyltransferase {ECO:0000256|RuleBase:RU368004};
DE            EC=2.1.1.211 {ECO:0000256|RuleBase:RU368004};
DE   Flags: Fragment;
GN   ORFNames=N305_04534 {ECO:0000313|EMBL:KFW78469.1};
OS   Manacus vitellinus (golden-collared manakin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX   NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW78469.1, ECO:0000313|Proteomes:UP000053258};
RN   [1] {ECO:0000313|EMBL:KFW78469.1, ECO:0000313|Proteomes:UP000053258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW78469.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-
CC       methyltransferase. {ECO:0000256|RuleBase:RU368004}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-
CC         methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:43100, Rhea:RHEA-COMP:10339, Rhea:RHEA-COMP:10340,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65315, ChEBI:CHEBI:74478; EC=2.1.1.211;
CC         Evidence={ECO:0000256|ARBA:ARBA00000660,
CC         ECO:0000256|RuleBase:RU368004};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU368004}.
CC   -!- SIMILARITY: Belongs to the TRM44 family.
CC       {ECO:0000256|ARBA:ARBA00009056, ECO:0000256|RuleBase:RU368004}.
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DR   EMBL; KL670101; KFW78469.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093S6C6; -.
DR   STRING; 328815.ENSMVIP00005004752; -.
DR   Proteomes; UP000053258; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0141101; F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030488; P:tRNA methylation; IEA:UniProtKB-UniRule.
DR   Gene3D; 4.10.1000.10; Zinc finger, CCCH-type; 1.
DR   InterPro; IPR011671; tRNA_uracil_MeTrfase.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR21210:SF0; TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR21210; UNCHARACTERIZED; 1.
DR   Pfam; PF07757; AdoMet_MTase; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU368004};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00723};
KW   Methyltransferase {ECO:0000256|RuleBase:RU368004,
KW   ECO:0000313|EMBL:KFW78469.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053258};
KW   S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU368004};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU368004};
KW   tRNA processing {ECO:0000256|RuleBase:RU368004};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00723};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00723}.
FT   DOMAIN          497..527
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50103"
FT   ZN_FING         497..527
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFW78469.1"
FT   NON_TER         541
FT                   /evidence="ECO:0000313|EMBL:KFW78469.1"
SQ   SEQUENCE   541 AA;  62247 MW;  F4B61F7C08A6AB12 CRC64;
     IFSDVYNGTV TFLPLEENSE GKCLIKKCNI YQIQLKHIKD EEWSVSVVVP FPEDWFSDGI
     AYPKLAWLGN ELLSKLAKWS VEQKPSEFKS TLSLISVAKY SKVYQDLKEK YKEMVKVWPE
     VTDPEKFVYE DVAIATYLLI LWEEERKEKG LTKKQSFVDL GCGNGLLVHI LNNEGHSGRG
     IDVRRRKIWD MYGPETHLEE STIMPGDSHL FPDTDWLIGN HSDELTPWIP VIAARSSYSC
     CYFVLPCCFF DFHGKYSRRQ SKKTQYREYL DFIAQVGFVC GFHVEEDCLR IPSTKRVSLI
     GKNRIYPPTE SALIDKQITQ FINNRRTCTG ITCDRRVGFN HKDHCDGVCE EAGSELPADE
     TETAGTTWMP GFQPREKVEQ IRNCASLPRE FVDEVVLNVA NLLLNATPQK SYSNMQGGNM
     NSWNQGESLS LKEVAEHLNK ETLKRLKSEY GGLQTLLKNN HQVFEVLNGR VHIRDWRKEK
     PSSKTKPEAK RRLSAEAFKT RLCWFFIHHP DGCSLPSESC PYAHGTEELR QSQIIKKKKH
     I
//

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