ID A0A093X1W3_9PEZI Unreviewed; 618 AA.
AC A0A093X1W3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Aldehyde dehydrogenase {ECO:0000256|ARBA:ARBA00044146};
GN ORFNames=V490_08926 {ECO:0000313|EMBL:KFX86700.1};
OS Pseudogymnoascus sp. VKM F-3557.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1437433 {ECO:0000313|EMBL:KFX86700.1, ECO:0000313|Proteomes:UP000029320};
RN [1] {ECO:0000313|EMBL:KFX86700.1, ECO:0000313|Proteomes:UP000029320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-3557 {ECO:0000313|EMBL:KFX86700.1,
RC ECO:0000313|Proteomes:UP000029320};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024149};
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFX86700.1}.
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DR EMBL; JPJS01002597; KFX86700.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093X1W3; -.
DR STRING; 1437433.A0A093X1W3; -.
DR HOGENOM; CLU_005391_1_0_1; -.
DR Proteomes; UP000029320; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000029320}.
FT DOMAIN 90..558
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 618 AA; 66945 MW; B4725AE39DE420F8 CRC64;
MASLASNEGV KQIVERIMDG TLWESEAETM LVRSAAIGLC ITSLCLFSAI KFTKWYNSEP
AIPYTVSPPQ KSTNPPPNWN EPSIKLSGSS AIHCYAPATG EFLGLVNPST PTGIDRSIQL
AQTAQEKWAR TTFSQRRQVL RTLLAFILKN QEEILRIACL DSGKTMIDAT LGETLTTVEK
LRWTILHGEK ALTPERRPTN LLMMYKENKV YYEPLGVVAA LVSWNYPFHN LMGPIISAIF
SGNGIVVKSS ENTAWSASYF TTIARGALSV CGHDPNLVQV VVCWPQVANH LTCHPDIAHI
TFIGSRPVAH HVAASAAKAL IPVVVELGGK DAAIVLDSAA PDISRIIEIL MRGVFQSSGQ
NCVGIERIIA GNAVYDKLIT LLETRIRKIR LGSDLDSSPT ENVDMGAMIN PASFSRLESL
VKSAVADGAR LIVGGSRYEH PVYKHGSYFQ PTLLVDVTAS MEIAKEECFG PICVVMRAAD
AAEAVEIANS PNFGLGASVF GANGYELTEV ARAVRSGMVA VNDFGAYYAV QLPFGGVGGS
GYGRFAGEEG LRGLCNIKGI CRDRWSWMGA KTAIPPPLRY PIANTRKGRK LVTAIVDFGY
QPGVWDKVKA LGRLIRNS
//
