ID A0A094AEY5_9PEZI Unreviewed; 1940 AA.
AC A0A094AEY5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=O988_05241 {ECO:0000313|EMBL:KFX96586.1};
OS Pseudogymnoascus sp. VKM F-3808.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1391699 {ECO:0000313|EMBL:KFX96586.1, ECO:0000313|Proteomes:UP000029329};
RN [1] {ECO:0000313|EMBL:KFX96586.1, ECO:0000313|Proteomes:UP000029329}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-3808 {ECO:0000313|EMBL:KFX96586.1,
RC ECO:0000313|Proteomes:UP000029329};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFX96586.1}.
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DR EMBL; JPJR01001031; KFX96586.1; -; Genomic_DNA.
DR STRING; 1391699.A0A094AEY5; -.
DR HOGENOM; CLU_000893_1_0_1; -.
DR Proteomes; UP000029329; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000029329};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1371..1557
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1657..1924
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1940 AA; 216705 MW; BB16FE30253C8535 CRC64;
MDTRARGIRR KALQKIAALS VTSPRKSESN QDLERLYNIF PSRPSSKAGV NGHTDEDNNV
PLGGVAMNIR EFEVLLALCK AAPLLQDYQS AERLAAQLAP YVLEAHTQVF VTSPFFREIE
PSPIESLNFN LASALLSLGI NHPGLQSAIS KNFTAYLDRC QYTARAVISR QGSAVGKEEI
GDVDDAINVA RVAIALLGFL DAATIQANFW TAGERLALIT VVKRILSEDF LVAVETSFSR
IRNYHSTNRE VKEWKRHVRH YAATGRPLGA MLIQRSFMWL LVATSSLLIT DTKTLRDHCI
LELMMGDMTP RPLTSHTAEE SLPSIETMAE FATEEMNKLE DGADYLRIGS AWQQRIAFAV
KAGALTCYLN CVTFNDDVAD AESLMVWLEE TLSDPIQMAD ENLANVVLRS MALVAQISPS
LAPNMSKILP RFIVQGSPRG ETVAVASTCL AFVLRLLSED AVITTLYSLG NVLTPITSTE
RVVANQTRGD TANGHGSPAF YGVKQTGSAI SLAAAGEFEV AVAYGNVIKA IRVIAEACAD
DKITALAQSM LLQKITKIDT AVDAAIIYEA AVLASTGAPV ELKSLLKFYS RLTQEALLDE
NESLLAALLK TRNYLSSTLK KGSSAYDIYF EYLLETIISR GDVHQLHHTR ESDVESAARE
IGTLVQPLAL LMSANNLGED ETTDDDIWAL VRDAWFNMVV HGFTTCTERG RQYLDELRIL
AVNSKPLVTE QRGEQLESDI ELNSVLRRGM NSEHEAIQKK RLTSLIPSKA GEIRSLSYRK
TIFLHTAYLV ETLRADSGDC TKAMIYFLEP GMRTGNMSSV MEAITMSVVD TYLRKAMSGV
NPTFSAPCVA EQLVSIFCGC CHRIERVQQA ATACADKILS NVTSALCQRS SLFALLELLS
LMWISCLEAE TDEYEWKSSY TSARSKVTIQ LGDNFEFRGR TLNTIYKKAK VWVMNVINVA
PLDIKGLLQT YLSEYDDDGA YGHISLGRSF AAEMGGMIPV TDQRLGAIDR HGDAKINAIS
DFVAQYTTRQ EYRYAEGLPN YDAEWVNFMK VATSRNSTTV ESLGTEHADA LTVLNFLDAR
MQKGKFIPIS ELRDMLRRAA AFLCRAKGDE AAVVKHLVGI PFAHFSKQSI KLGISLWQGV
INENPRMESR IIMEIAQQWE NTIHMKKGVF NDEFKHPDPF FIRKEYAPSD KDTLHKKQQH
AQNLLAPHSR LLQFLASHFN ATRLCSPHTQ KTFVRLLQAT LNGLMHSTGH PLSRELRFNI
VMLSLKVLRH GTVLTAAGQY RLKNQMLSAA LSWFSFAPCF TFGGNRLQLK AEAKLLSDVA
ASLDSVRHIG AKNASTLKRL QDKEELLFAL LENEQSRLRV WLDPLGEGKA SHHAEPSEAI
LSRLVKTAWF VSPSLAISLA TRFHSARVHT DVRSLLLSDP LGGINDPEGL NILMGGEYQS
DLTWQLKYLL FWTPVNPITA VTYFLPSFSD NPFIIQYAMR ALESHSVEVT FFYVPQIVQS
LRYDTLGYVE RYIMETAQFS QLFAHQIIWN MKANSYKDED SQIPDGIKPT LDHVMGRMIG
CFTGADRDFY EREFKFFDEV TSISGKLRPF IKRPKPEKTQ KIEEELRKIK VDVGVYLPIN
PDGVVIGIDR KSGKPLQSHA KAPYMATFRV KKDVASEMEE TEDMLEAADP RKRVPENSIE
VWQSVIFKVG DDCRQDVLAL QMIAAFRGIF SNVGLDVFVF PNRVTATAPG CGIIEVLPNS
VSRDMLGREA VNGLYDYFVS KYGTPDSVRF QAARSNFVKS LAAYSIIAFL LQFKDRHNGN
IMFDDAGHLI HIDFGFCFDI APGGVRFERA PFKLTTEMVA VMGGSSNTQS YRWFEELCVK
AFLAARRHVD ALCRIVRLML DSGLPCFKPE SIKHFRERFV LEKSEREAAV FVRGLVRRSH
NSYSTGVYDQ FQLMTNGIPY
//
