ID A0A094AMQ9_9PEZI Unreviewed; 876 AA.
AC A0A094AMQ9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
DE Flags: Fragment;
GN ORFNames=V493_01746 {ECO:0000313|EMBL:KFY30684.1};
OS Pseudogymnoascus sp. VKM F-4281 (FW-2241).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420906 {ECO:0000313|EMBL:KFY30684.1, ECO:0000313|Proteomes:UP000029327};
RN [1] {ECO:0000313|EMBL:KFY30684.1, ECO:0000313|Proteomes:UP000029327}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4281 (FW-2241) {ECO:0000313|Proteomes:UP000029327};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY30684.1}.
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DR EMBL; JPJV01000645; KFY30684.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094AMQ9; -.
DR STRING; 1420906.A0A094AMQ9; -.
DR HOGENOM; CLU_005943_1_0_1; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000029327; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000029327};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 43..308
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 581..860
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
FT NON_TER 876
FT /evidence="ECO:0000313|EMBL:KFY30684.1"
SQ SEQUENCE 876 AA; 96281 MW; 14B31E5879418935 CRC64;
MEDSLTTTAY LLASDAGRRG EIVESVVGGL ESGSIKLGDV VLSMQGPLFA DDQEQRTQAM
AYIAAIMRVI KADALTRANV TLLVKFIESR LGLDTSGFKE SVQTLRYLSA MTRFESSLAA
PVLSAVFNAV QGRFAKEPVM TRFEVYNLLN ELLSRHRAAI KVTGVDFINV LIELSSSERD
PRNLMLIFSM VEVVLAEWEI EDIEQLQEDL YDLLSRYFPI TFSAKKTDPA GIDPAELVLR
LRKCFAAYSG FATSLFPNLI QRLDDPNRLN AKADVLLTMK ACIKRYHPDT VAQWSTPLWD
ALKYEIFNSS DDSQAPKALD VLRAIATRLS ADSTLQTLPG TVLYTYVGAI VEECMTRVRE
NGPKYSASAG AIMGSIIAAS PFAYHLVMRA ALPALLREFS GRDVSVPERR AVVETINSLL
DGKFEVLRRQ EKWEFSAVSI IDGLSYGADV ASAGGEDVGA ANKGLGYYRD ELTALYMGVA
RDTQSDDKQF RIAAMQGLAK LLRLPQFLER GNVDAYIQFF AGVVLETADV NEPVRREAIK
ALQDCSVVYA SLVIEKAFPV LLAALPDVLE GDESVKENLA VLEAFGDVGS RGTLMDTLFR
RLLSKLDIVL RANESQKYGH LVLAGLLYTI EQRQAQKESG EVEARDVEAY RSLVDELLNR
TATLKVHEKK WYVGARDLET AAGKVQPDVT FLDLVGRVIM AATSPMSFDD QEWIFARAFS
LNVAYDKVTA ANIALTSADD LPTDYLSFAA TSESTVTKDS EVVTDISKRG DIHNAQFDLL
SGPADKLRVL ALTKYILAAL RRDDRATKRK RTLPVDASAA ATNLVTYLTT ATTCPPTLLS
TLLDTLALLI NKFGALTPAV TTQLLSLFSS LPTLDR
//
