ID A0A094EFM6_9PEZI Unreviewed; 650 AA.
AC A0A094EFM6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 13-SEP-2023, entry version 29.
DE RecName: Full=Lipoyl-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V499_04796 {ECO:0000313|EMBL:KFY75238.1};
OS Pseudogymnoascus sp. VKM F-103.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420912 {ECO:0000313|EMBL:KFY75238.1, ECO:0000313|Proteomes:UP000029295};
RN [1] {ECO:0000313|EMBL:KFY75238.1, ECO:0000313|Proteomes:UP000029295}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-103 {ECO:0000313|EMBL:KFY75238.1,
RC ECO:0000313|Proteomes:UP000029295};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY75238.1}.
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DR EMBL; JPKB01000728; KFY75238.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094EFM6; -.
DR HOGENOM; CLU_000395_3_2_1; -.
DR Proteomes; UP000029295; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45007; CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED; 1.
DR PANTHER; PTHR45007:SF1; CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}.
FT DOMAIN 7..453
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 122..318
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 650 AA; 69693 MW; BEC76F802079C510 CRC64;
MTQPYSTYYQ QLTRSRGEIA IRILSSAREL DLETYTLYTA DDTSHTLQST HAVSIPSPST
YLDIPALIAI IKSHNIDSVH PGYGFLSESA EFAHRAWTEA GAVVIGPGWE TLARTGDKLA
ARQLAEECKV PVLPALQTPT DNVEDIRRFA TQIGWPIIIK AVDGGGGRGI RIVREEGDLA
GLMERALRES PQGLVFAEKA AVDGYRHVEV QIVGDGTGNV RHLWERECSI QRRFQKVVEF
APSSIRDRAV VGRVIEAAMR MARKVSYLSL GTFEFLVHSS KPEFYFLEVN PRLQVEHTIT
ESLCPGLDLV KVQLCLAAGQ ELDTLLPNIS RDPLVPPPLH SLQLRITAED ATANWALNTG
TINSLALPSG NGIRVDHHLT AGLVVKTDFD SLLAKIVITT SSWTDLVAKA IRALNDTHII
GVKTSLPALR GILAHPAFKA QACDTQWLES TLPALLAAGT SITATIPSPA TPSAAPAFAP
SSSSAPLRKG DAWSLTLTPT TTASSSSTPP PAPAHLLLTK LLRNDFPSSL TADILFTAPS
APPMSYTLAL TSTAASAGAL TSAHRRGEAG NARHIVFPFP GQLVELLVDV GDRVGKGDVV
AVVKQMKMEL EIRASGEGVV GWVFEGEDGD EVGEGVLAVE LVDEGGRAKL
//
