ID A0A094EZ28_9PEZI Unreviewed; 1504 AA.
AC A0A094EZ28;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
GN ORFNames=V500_11134 {ECO:0000313|EMBL:KFY81733.1};
OS Pseudogymnoascus sp. VKM F-4518 (FW-2643).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420913 {ECO:0000313|EMBL:KFY81733.1, ECO:0000313|Proteomes:UP000029284};
RN [1] {ECO:0000313|EMBL:KFY81733.1, ECO:0000313|Proteomes:UP000029284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4518 (FW-2643) {ECO:0000313|Proteomes:UP000029284};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY81733.1}.
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DR EMBL; JPKC01003633; KFY81733.1; -; Genomic_DNA.
DR STRING; 1420913.A0A094EZ28; -.
DR HOGENOM; CLU_000700_0_0_1; -.
DR Proteomes; UP000029284; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 3.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000029284};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1504
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001901748"
FT TRANSMEM 1356..1377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1435..1461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..673
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 710..1345
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1504 AA; 168476 MW; CE08F4E63C76A8B2 CRC64;
MRLRVAEAVP GWRSLLLTTL LYGTSLAAKD APVVTSNKFA NSPYDLRYFD DSDVILMQDF
NEDAIFRSAN AGESWDKIAA IPEGVSASLV MHPFDNTRAY VLTEDITHFR TEDRGMTWTQ
FETRSIPDVR EEYPLSFHAG NKDKIIVNAL DCMLGLYCER TSTYTLDGFQ TPAKPLRDNT
AGCQWAKGTE LFAERESQVD DSRILCITEG KYSRYSKDYK LKISDSFFVD EFEPVLEEGR
TVTGVSRIAA VKSYILAASV AEKTDEMALY VTYDTLKWHR AVFPHDHKLV EEAYTILEST
NYSIQIDVMT TKKSNPMGVL LSSNSNGTYF TRNVEHTNRN KGGNVDFEKV AAIQGIALVN
VVDNWEDVEK SPREAKKIKS QISFDDGRTW RGLKAGDDDL HIHSVTDASN SGRIFSSLAP
GIMMGVGNTG KHLKAYNKGD LYVSEDAGVK WTKALSGPHK YEIGDSGSIL LAVEDTVTKK
MKYSLDRGRN WKEIDLPHKV SPYVLTTTLD STSPKFLFMA SARSADVEEY YIMSINFEGM
NERKCEDKDL EKWYARVDKE GKPTCLMGHK QYFMRRKVDA DCFMKKDFVD PKAEFEKCDC
SDIDYECDFN FVRSEDGKKC VARGPPLVPD GACKKPDDTF KGSSGWRLIP GNDCIPPKEG
AKDGLVSTPC KDTIAPPASG KVSHTSQSLE GKLLQDHIYF ERTETSSGVD ETVIAQTDKG
VFLSRDHGKK WNEILKDKKV KYVVRHTYLN DRVFFIASDD KVYYSVNRGD DIQEFDVKVP
HPADYGYGNP MSFHPTKKDW IIWTGKSCSA GGDSCHAVAS ISKDRGDSWK TLARYISKCE
FIYAEKTARE AEGEKLIFCG ARTKESNDPK NNPWKLMGST NFFEDSVTHI DDIQDFATMS
EYIVVAAKDD KGELTLKSSV DGKTFADALF PSNFRIPHQH GYTVLDSSTH AIFLHATVDT
TTDLEYGGII KSNSNGTSYV LSLNGVNRDR AGFVDFEKMS KLEGVALANV VTNYETASKD
GHKTLKTMIT HNDGAEWRYI TPPSKDVEGK KFSCSGSIQK CSLNVHGFTE RRDKSHTYSS
PSAVGIMLAV GNVGESLKPF DESDTYITRD AGVSWIQVKK GSYMWEYGDQ GSIIVLANDR
KDTDVVYYSR DEGDTWTEYK FSDSKVRLED ITTLPSDNSR NFLLWARGSD GTVTTINLDF
TGLSDRQCVL DETRDENEDY YLWSPRHPTQ DDNCLFGHIS QYHRKKASAD CYNGHIIEAL
HDIKSNCTCT RQDFECDYNY QALAGGECLL VPGLTPVDRI QECRDNPEQI EYYEPTGYRR
IPLSTCEGGK EMDRIVGIAC PGKEEEFSKK HGLGGFWIFL IVLFSIGAAG SAGWWVYHNW
ADKFGQIRLG EQCIYPPFVC LFSSISHFYG ESGTQVHKLT SDTASFDEET PFIKYPIMAV
AGVGAVIIAA PSVASSVWGW LMKTFGGRRG TRFTTRGSFA RGADYAAVDE DEGELLGEDS
DDEV
//
