ID A0A094FRK5_9PEZI Unreviewed; 1556 AA.
AC A0A094FRK5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Succinate-semialdehyde dehydrogenase, mitochondrial {ECO:0000256|ARBA:ARBA00019842};
DE EC=1.2.1.24 {ECO:0000256|ARBA:ARBA00013051};
DE AltName: Full=NAD(+)-dependent succinic semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00030806};
GN ORFNames=V500_03736 {ECO:0000313|EMBL:KFY93361.1};
OS Pseudogymnoascus sp. VKM F-4518 (FW-2643).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420913 {ECO:0000313|EMBL:KFY93361.1, ECO:0000313|Proteomes:UP000029284};
RN [1] {ECO:0000313|EMBL:KFY93361.1, ECO:0000313|Proteomes:UP000029284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4518 (FW-2643) {ECO:0000313|Proteomes:UP000029284};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid degradation; 4-aminobutanoate degradation.
CC {ECO:0000256|ARBA:ARBA00005176}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY93361.1}.
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DR EMBL; JPKC01001171; KFY93361.1; -; Genomic_DNA.
DR STRING; 1420913.A0A094FRK5; -.
DR HOGENOM; CLU_003835_0_0_1; -.
DR UniPathway; UPA00733; -.
DR Proteomes; UP000029284; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0009013; F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0009450; P:gamma-aminobutyric acid catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd07103; ALDH_F5_SSADH_GabD; 1.
DR CDD; cd12148; fungal_TF_MHR; 1.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 4.10.240.10; Zn(2)-C6 fungal-type DNA-binding domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR010102; Succ_semiAld_DH.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR InterPro; IPR001138; Zn2Cys6_DnaBD.
DR NCBIfam; TIGR01780; SSADH; 1.
DR PANTHER; PTHR43353; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43353:SF5; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR Pfam; PF00171; Aldedh; 1.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF57701; Zn2/Cys6 DNA-binding domain; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000029284};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 336..366
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000259|PROSITE:PS50048"
FT REGION 290..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1318
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 1556 AA; 170774 MW; D8CCD3CBC2CE1280 CRC64;
MLSPKKTIFA PHLGGIEVGY RLSATTPDLS KPTVVLFNPF TATADYYLPE FENKTLTDAL
NLLAIEPLGH GQTRAKRTDT FTYWDSAIMG LQILEMLGIE HAYALGTSQG GWIAARMALL
APERIKGIIL IGSSMDYESP RSRELGCWDG PAACSGLVAL NGDLTPAHDF EPGDAYYDFL
MEIGFGKNVD KATRGFWAKT IRDNYNGDEG KKRVSMAAVN LASRDGLHER LPNIRCPILW
LQGTDDVVFS FKNAEEEIKL FINSAKTRLW KGGERASLAP RSADLISGVD AKDLPVMSNT
DQEQRSEPSR YSDAASPRRS TDSSAPTGKR RRVALACSNC RHRKSRCDGG RPKCSLCNEL
GCDCLYEQAG TTSSLTVGRG YISRLEQRLE DIEEALKGLQ QPQNVSRSDT SYSIHDDAGL
LPNNGASTGG ESSSRVPFRP VIGNTEISEV DTAEDSIDGM GAIKFTDEED CGYFGPSSNI
AFVGHISLAM TRANAPSPVV PSPSNRARVA TGLLSVSRPH HVSQEVNASG LDRLHGGVNI
YALPSEPRAW SLIRKYFLKT GQLLPFIHEQ SFCETYFQMK RDNCTMARRT WLGLLNIVFA
MAATLSIDGD MSSEKRIEES DVYYQRANSL CDKESRRNIS VELVQYLLIS GQYLQGTQKS
VQAWTVHGLA ITAAFQLGLH SPRANQDFSP LEREIRKRVW FGCILLDRTL SMTFGRPAII
PETYVKLDLP NILMQIVGNT TQNEASPQMD AVFYTATIKL YSVMYHIIDS CYGQNLGFQD
SSTNMEAVSL VLAGERQLEE WKQQLLPLLY LRVSEEPFGA QDLDKMDSNN QIVERFNVVL
SLRFHNLRIL LHRPFLEKFL NDYSGNDSNT QSTENKILHQ VGINSVQTCV NSAKIIISIV
RTVVSSTDWH RDLLGAWNYS LFYAFNASLV VFGALLVAPK DSSLNSHWGF VEQSRPYFSM
AIEALRNLDR GNRVVERCVQ YLSQLSSALA GPTNPSDMAP NYCSLNMDPF TSQSGSACVL
QQMQSLKQLP MDMELSEFMI NTDMDFLGGY IDVNRHYVDG QEIKDSTLFI QKGYVNGEWV
NAQSGKTFGV YNPATTKIIG TCPEFSKADT EAAIRAAETA FTSFRNTTSR ERARLLQKWY
HLMVENSEDL ANLITWESGK ALCDARTEVT YAASFLEWFS EEAPRTYGDV IPASIPGNRV
FAFKEPIGVC GLITPWNFPA AMVTRKVGPA LAAGCTVVIK SPGETPFTVN ALIELARRAG
IPKGVINIAT AASNTVEVGH TLTSSPIIRK ISFTGSTAVG KLMMRQCAET TLKKVSLELG
GNAPFIVFND ADVDTAVAGA ISSKFRSSGQ TCVCPNRLIV QDDIYDIFAA KLAAKVREFK
VGDSLETDGV THGPLIHDRA VAKVQSHVHD AEAKGGKVLV GGRKRPDLGP NFFEPTVITE
MTEAMLLASD ETFGPVAGLF RFKTEADAVA LANKTDVGLA GYLFSKDIQR IWRVSEALQV
GMIGVNTGLI SDPATPFGGV KSSGIGKEGS KYGIGEYMVT KVVTLGGMGI PLSSHL
//
