ID A0A094G5H2_9PEZI Unreviewed; 1668 AA.
AC A0A094G5H2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V500_04724 {ECO:0000313|EMBL:KFY91295.1};
OS Pseudogymnoascus sp. VKM F-4518 (FW-2643).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420913 {ECO:0000313|EMBL:KFY91295.1, ECO:0000313|Proteomes:UP000029284};
RN [1] {ECO:0000313|EMBL:KFY91295.1, ECO:0000313|Proteomes:UP000029284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4518 (FW-2643) {ECO:0000313|Proteomes:UP000029284};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY91295.1}.
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DR EMBL; JPKC01001584; KFY91295.1; -; Genomic_DNA.
DR STRING; 1420913.A0A094G5H2; -.
DR HOGENOM; CLU_000972_1_1_1; -.
DR Proteomes; UP000029284; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR CDD; cd21206; CH_IQGAP; 1.
DR CDD; cd05127; RasGAP_IQGAP_like; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 9.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 8.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000029284}.
FT DOMAIN 278..384
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1030..1246
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1668 AA; 190348 MW; D8D90313AD9D70F5 CRC64;
MSYRHPLHQI QANDYSSQLA KRQPSTASTS SSAYSHPSEA SYLSRTSTIS STASSGYQQP
AHKRGLSEAK GMSPATDLRP GSSGRGFSTP NSEDPFQSVR LSLRPLPQVP AQTYPSPPSK
QQLFQHSRGQ SLDVKPMYND TAASPPPKRT GALRPNSMLL SRADSTRTVR SNSMQPSSQL
SPVHTPVAAP DLQSLGKSST GHLRTLSKFA EVSSPNEFAI SSPAQEVAGL HGRRRLQRTD
KTANGGSAVA LSNGTGYSWE GRNWMDKQRQ FLQAYEYLCH IGEAKEWIED IIHRPIPPII
QLEEALRDGV TLAEIVEALQ PDNRFRIFRN PKLQYRHSDN IAIFFRFLGE IELPDLFRFE
LIDLYEKKNI PKVIYCIHAL SWLLYRQGVV DFRIGNLVGQ LEFEHHELEA MQKGLDKAGV
SMPSFGNMGA DFGVPEPEPE PEPVESEEDR IERELQENEP SVIDLQAQIR GALQRMRLAN
TMEKLWNSED WLVDLQSRIR GDFSRQIIDY RLSMRRFAVN LQSASRGFIL RKQLMNRTEF
FKSSEAEILK LQSLFRARKV RAEVCITKSQ LKNESFAVRD VQAAVRGFLM RKRMEQQHKE
TRSVATPVRG LQSSIRGMLL RSTIANDRHI LDAETASIAL IQANSRAMLT RIQVSRQKQA
LEASTGIWKA LQAVSRGHLL RKQLAFTRKE LKAQSPSVAM FQAAIRASAV RSETAKILAA
LESEEPTVTE VQSLVRGMLS RQRIAAQNEA LSRQTVNITK LQGYARGFLS RAVNAELRAD
LYSNTPAIIQ LEGLIRAMLH RNDIGTLLGE LEAEEDSIVA FQTAARGLLV RAKFAEKQKF
FKENMQKVIK IQSFVRGRLQ GEAYKSLTTG KNPPVNTVKN FVHLLNDSDF DFNEEIEFER
LRKTVVQQVR QNETSEQYIE QLDIKIALLV KNKITLDDVM QHQRNFGGHA GNLLPSTAMS
SGNHFDLKAL NKNSRKKLDT YQQLFFTLQT QPQYLARLFR MVREQGMAEQ ESKRVETLMM
GLFGYAQKRR EEYYLLKLIA RSVKEEVDGS HTIQDYLRGN FFWTKLLANY TRSPRDRKFL
RELLGPLIRE NIIDDPALDL ESDPMQIYRS AINNEELRTG RPSHRPLDVS REVAIKDKET
RDLFIDHLRD LREISDQFLL ALEEILPKMP YGIRFISQTL FECLCERFPG EKQAHILQIV
GQWVFRSYIQ PPLTSPQEVG VVERQLTPLQ KRNLGEVSKV LCQVTTGKLF GGDNIYLQPL
NAYVGSAIER MGIIFSDLID VPDVEQTFDI DEFNDLYSKT KPTLYIKMAD IFAIHNLVIK
ELPQICPNRD DMLREIIQEL GSAKNNEMEW SGVTSSEIQM TLNPKLHDTD DPEAAVKALF
METKRCVLYI IRVQSGPNLM DILVRPITRE DEQKWKALVR EEFAAGSNTR GAYSDANMMD
ITSMPYSELK RTALENIMRL ETQFGRISRH NQYQDLLNAI AVDIRTKSRR RIQRQRELEG
VRLTLGNLHD KAAWLEQQRK SYDNYIEQAM MTLQNKKGKK RFLLPFTRQY NHERELQRTG
RQPKFGSFKY SARNLADKGV LVSWAGYTEK QYEKINVTIS CDQVGIFFIE GSLGSIQIPG
ASAQVPLEDC LSAQFNNHQF MNLFEGGLKL NVNLFLHLIY KKFYRSTD
//
