ID A0A094IAT1_9PEZI Unreviewed; 1360 AA.
AC A0A094IAT1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=phosphoribosylformylglycinamidine synthase {ECO:0000256|ARBA:ARBA00012747};
DE EC=6.3.5.3 {ECO:0000256|ARBA:ARBA00012747};
DE AltName: Full=Formylglycinamide ribonucleotide amidotransferase {ECO:0000256|ARBA:ARBA00032632};
DE AltName: Full=Formylglycinamide ribotide amidotransferase {ECO:0000256|ARBA:ARBA00029823};
GN ORFNames=V500_03624 {ECO:0000313|EMBL:KFY93662.1};
OS Pseudogymnoascus sp. VKM F-4518 (FW-2643).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420913 {ECO:0000313|EMBL:KFY93662.1, ECO:0000313|Proteomes:UP000029284};
RN [1] {ECO:0000313|EMBL:KFY93662.1, ECO:0000313|Proteomes:UP000029284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4518 (FW-2643) {ECO:0000313|Proteomes:UP000029284};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC phospho-D-ribosyl)glycinamide: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004920}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the FGAMS family.
CC {ECO:0000256|ARBA:ARBA00008608}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY93662.1}.
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DR EMBL; JPKC01001129; KFY93662.1; -; Genomic_DNA.
DR STRING; 1420913.A0A094IAT1; -.
DR HOGENOM; CLU_001031_0_2_1; -.
DR UniPathway; UPA00074; UER00128.
DR Proteomes; UP000029284; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01740; GATase1_FGAR_AT; 1.
DR CDD; cd02203; PurL_repeat1; 1.
DR CDD; cd02204; PurL_repeat2; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 1.10.8.750; Phosphoribosylformylglycinamidine synthase, linker domain; 1.
DR Gene3D; 3.90.650.10; PurM-like C-terminal domain; 2.
DR Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 2.
DR HAMAP; MF_00419; PurL_1; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR040707; FGAR-AT_N.
DR InterPro; IPR010073; PurL_large.
DR InterPro; IPR041609; PurL_linker.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR036921; PurM-like_N_sf.
DR InterPro; IPR036604; PurS-like_sf.
DR NCBIfam; TIGR01735; FGAM_synt; 1.
DR PANTHER; PTHR10099; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR PANTHER; PTHR10099:SF1; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR Pfam; PF02769; AIRS_C; 2.
DR Pfam; PF18072; FGAR-AT_linker; 1.
DR Pfam; PF18076; FGAR-AT_N; 1.
DR Pfam; PF13507; GATase_5; 1.
DR SMART; SM01211; GATase_5; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF109736; FGAM synthase PurL, linker domain; 1.
DR SUPFAM; SSF56042; PurM C-terminal domain-like; 2.
DR SUPFAM; SSF55326; PurM N-terminal domain-like; 2.
DR SUPFAM; SSF82697; PurS-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962,
KW ECO:0000256|PROSITE-ProRule:PRU00605};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000029284}.
FT DOMAIN 39..159
FT /note="Phosphoribosylformylglycinamidine synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF18076"
FT DOMAIN 183..232
FT /note="Phosphoribosylformylglycinamidine synthase linker"
FT /evidence="ECO:0000259|Pfam:PF18072"
FT DOMAIN 445..597
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT DOMAIN 882..995
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT ACT_SITE 1193
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1321
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 1360 AA; 147901 MW; C5E8E50F75F9A9A5 CRC64;
MEYLTLLGED AYTSSSARKI QDLIAKTSSA KVDEVSAVYI HYARLKQGTN DVAKETDAKL
RQLLPNPRPD FFREVSGGSS GNFRVYYVTP RNISPWSSKA TSIAAVCGVK GLERIERGRA
ILVKFAEPFE GSDDSFKHVL FDRMTENISS SEPDVKGMFA EGQRIPLEVV DIFAEGAKPI
EILKGYNKER GLALDEPEME YLIQAYSKIG RSPYDVELFM FAQVNSEHCR HKQFNANWTI
DDVAMGKSLF EMIKNTHKNN PKYTVSAYSD NAAVLEGNFA SFWAPDYNTG SWKATKEMVH
YIIKVETHNH PTAISPFAGA ATGSGGEIRD EGAVGRGSQP KAGLCGFWVS DLLIPDFEQP
WEIDFGKPAH YASSLDIMLE APIGSARFNN EFGRPCLTGC FRTLLTDTGS NEAEDYRGYH
KPIMIAGGVG TVRPQFAIKR QGDVKPGAHV IVLGGPAMLI GLGGGAASSN ASGEGSAELD
FDSVQRGNPE MERRAQMVIN ACCALHDANP IAMIHDVGAG GLSNALPELV KDAGYGGRFE
LRQIESADSS MSPLQIWCCE AQERYVLCVN EEGLNKFVNI CNRERCGFSD VGTVTGTIGD
SESTLVVTDR EGTEYPKPID LPMTTLFPRD RKLERNVKTK KNNMKAFDSF QSLCSLKTTK
SCRGSAEFLH RAMEIVLKVP AVGSKAFLIT IGDRTVGGMT TRDQMVGPWQ TPVADVAVTV
TSLATGGMLT GEAMAVGEKP ALALISPAAS SRMAVAESLL NLAAADIQGG LDRVRLSANW
MAAVNHEGEG SALYEAVQAI GMEMCPKLGI SIPVGKDSTS MKASWKDSSN GESKSVTAPV
TVVISAFAPV QRVSHTWTPA LRRLEDVGET VLMFVDLAQG KQAMGGSAFA QACGQLGNES
PDVHDIDLIA DYFDAITQLH ESGIVLAYHD RSDGGLFTTI VEMMFAGRCG AEIMLDGVAK
SDETGDVLDA IFNEELGAVF QVKKSDEINF IRCFATCGPP PGLVKKIGRI PAATKQELSI
RYKTETVTHL DRSTMQEWWS STSYQMQRLR DNPASADSEF SLIKDNKDPG LSFNLTFDPK
ESILPMTTLL SSPFIKAPRV AILREQGVNG YAEMAFAFKA AGFDAIDVHM TDIIAGRSLA
DFVGIAACGG FSYGDVLGAG QGWAKSILMH EENARPEFKK FFERKDTFAL GVCNGCQMLS
RLAELIPGAE NWPIFVDNES QQFEGRVSMV QIKDNSDSPS VFFHGMDGSS LPIVISHGEG
RAQFKNDTDL QALTQAGLVP VRYTDNYGKV TEKYPYNPNG SAQGIAGVTS KDGRVLALMP
HPERSIMASV GSYIPDGMTE EWGEYGPWVR MFKSARRWVG
//
