ID   A0A094IBK6_9PEZI        Unreviewed;       456 AA.
AC   A0A094IBK6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=TFIIS N-terminal domain-containing protein {ECO:0000259|PROSITE:PS51319};
GN   ORFNames=V502_00449 {ECO:0000313|EMBL:KFZ25070.1};
OS   Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ25070.1, ECO:0000313|Proteomes:UP000029308};
RN   [1] {ECO:0000313|EMBL:KFZ25070.1, ECO:0000313|Proteomes:UP000029308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC       transcription regulation. May function in both SPT15/TBP post-
CC       recruitment and recruitment steps of transcription.
CC       {ECO:0000256|ARBA:ARBA00037349}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
CC   -!- SIMILARITY: Belongs to the IWS1 family.
CC       {ECO:0000256|ARBA:ARBA00037992}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFZ25070.1}.
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DR   EMBL; JPKE01000175; KFZ25070.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094IBK6; -.
DR   STRING; 1420915.A0A094IBK6; -.
DR   HOGENOM; CLU_045275_1_0_1; -.
DR   OrthoDB; 12240at2759; -.
DR   Proteomes; UP000029308; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR   PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR   Pfam; PF08711; Med26; 1.
DR   SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000029308}.
FT   DOMAIN          271..348
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51319"
FT   REGION          1..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..58
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..101
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..170
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..386
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   456 AA;  50864 MW;  5A9CDADAB4F5A814 CRC64;
     MSDAGGSSRA ATPEDQGSPQ DTPVADVNEN SDVEQAEEDG DRDDPDSELS EVDEAEFADF
     DPATVALGPV EIDEEVARTL KAGKRKRPDK DGEGAPKKPK EGKREKSKKR KERLERTQTG
     AEEYDSGADG EILEGRRTAK PKSVRIEGER KERDRAKERK REEERVQAVD QENLTPEQRR
     AAALDAAMDA ALKNPNKRRR KKDDVDLEEA FDDEIAALKI RMEQACQADN TARERSQPAV
     HKLKMLPEVV ALLNRNTVRH SIVDPDTNFL LSVKFFLEPL NDGSLPAYNI QRDLFNALAQ
     LPIEKEALLS SGIGKVVLYY TKSKRPEIGI KRIAERLLGE WSRPILKRSD DYKKRKIATK
     EYDFQAAQLA LRPSGAQSSS QPSNGLSRKE LDRERVLAAP RPGNRARLET HSASYTVAPK
     STFDPQRAVD PASRPIGASG MEAFRKMTAK KGTKRS
//