ID   A0A094JBV6_9PEZI        Unreviewed;       526 AA.
AC   A0A094JBV6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE            EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN   ORFNames=V501_07390 {ECO:0000313|EMBL:KFZ06463.1};
OS   Pseudogymnoascus sp. VKM F-4519 (FW-2642).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420914 {ECO:0000313|EMBL:KFZ06463.1, ECO:0000313|Proteomes:UP000029315};
RN   [1] {ECO:0000313|EMBL:KFZ06463.1, ECO:0000313|Proteomes:UP000029315}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4519 (FW-2642) {ECO:0000313|Proteomes:UP000029315};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC         Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC         EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFZ06463.1}.
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DR   EMBL; JPKD01002152; KFZ06463.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094JBV6; -.
DR   STRING; 1420914.A0A094JBV6; -.
DR   HOGENOM; CLU_013399_0_1_1; -.
DR   Proteomes; UP000029315; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR   Gene3D; 2.60.200.40; -; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR   PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR   PROSITE; PS50146; DAGK; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000029315}.
FT   DOMAIN          145..284
FT                   /note="DAGKc"
FT                   /evidence="ECO:0000259|PROSITE:PS50146"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..374
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   526 AA;  57259 MW;  135639C378D59979 CRC64;
     MTDHHATPAS PTRASSDPFM DPAAPDASGD GDIDFARDTT LVVGKDASLT LGTESLIVLD
     DDIQKDGKTS CCALCRPGSS NTRAIPFYNV LWAETSDSLL TISFASPISK TAVRPEFLTY
     PLPLDPEPAR IWIAKLLDRA YGESQKRKRA KVLLNPHAGK GSAVKWWIRD IEPILRAAHV
     ELDVHTTSSQ GEAVTIAEKL DIEAFDMVVS CSGDGLPHEV FNGLGKRPDA RRALAKIAVV
     QMPCGSGNAM SCNLTGSASP SLAALATVKG VVTPLDLISI TQGSTRTLSF LSQSVGIVAE
     SDLATENIRW MGQARFTYGF LTRLLKKRIY PCDLAVKVVI EDKAAIREHY RRESERRGTL
     GERRGNKDEN DDDSAASTSA ANEEGLPTLR YGTVNDKLPS DWVNVPYDTL GNFYCGNMSY
     MAADANFFPA TLPSDGLMDL VCIDGRIART AAVDLMLAVE NNKFFDKPLV SYRKVLGYRI
     VPREQESGYI SIDGERVPFE PFQAEIHRGL GTVLSCSGWK YEAQGP
//