ID   A0A094JKN1_9PEZI        Unreviewed;       325 AA.
AC   A0A094JKN1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=Mitochondrial glycine transporter {ECO:0000256|HAMAP-Rule:MF_03064};
DE   AltName: Full=Solute carrier family 25 member 38 homolog {ECO:0000256|HAMAP-Rule:MF_03064};
GN   ORFNames=V502_08642 {ECO:0000313|EMBL:KFZ09578.1};
OS   Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ09578.1, ECO:0000313|Proteomes:UP000029308};
RN   [1] {ECO:0000313|EMBL:KFZ09578.1, ECO:0000313|Proteomes:UP000029308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial glycine transporter that imports glycine into
CC       the mitochondrial matrix. Plays an important role in providing glycine
CC       for the first enzymatic step in heme biosynthesis, the condensation of
CC       glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the
CC       miochondrial matrix. {ECO:0000256|HAMAP-Rule:MF_03064}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycine(in) = glycine(out); Xref=Rhea:RHEA:70715,
CC         ChEBI:CHEBI:57305; Evidence={ECO:0000256|ARBA:ARBA00034060,
CC         ECO:0000256|HAMAP-Rule:MF_03064};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       inner membrane {ECO:0000256|HAMAP-Rule:MF_03064}; Multi-pass membrane
CC       protein {ECO:0000256|HAMAP-Rule:MF_03064}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       SLC25A38 subfamily. {ECO:0000256|HAMAP-Rule:MF_03064}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFZ09578.1}.
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DR   EMBL; JPKE01002940; KFZ09578.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094JKN1; -.
DR   STRING; 1420915.A0A094JKN1; -.
DR   HOGENOM; CLU_015166_0_3_1; -.
DR   OrthoDB; 5174168at2759; -.
DR   Proteomes; UP000029308; Unassembled WGS sequence.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015187; F:glycine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:1904983; P:glycine import into mitochondrion; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.50.40.10; Mitochondrial carrier domain; 2.
DR   HAMAP; MF_03064; SLC25A38; 1.
DR   InterPro; IPR030847; Hem25/SLC25A38.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   PANTHER; PTHR46181; MITOCHONDRIAL GLYCINE TRANSPORTER; 1.
DR   PANTHER; PTHR46181:SF3; MITOCHONDRIAL GLYCINE TRANSPORTER; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_03064};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128, ECO:0000256|HAMAP-
KW   Rule:MF_03064};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792,
KW   ECO:0000256|HAMAP-Rule:MF_03064};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029308};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|HAMAP-Rule:MF_03064};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW   Rule:MF_03064};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW   Rule:MF_03064};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_03064}.
FT   REPEAT          9..92
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          121..205
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          227..311
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ   SEQUENCE   325 AA;  34879 MW;  8B03F9CA0B5DDEEB CRC64;
     MSNGGQPRSS PVFHFTAGLG SGVLSAVLLQ PADLLKTRVQ QSGSSSLSAS FREILAGPKA
     IWGFWRGTAP SALRTGLGSA LYFTSLNALR QHVARSTLLR NIGVVDGTKV QPSTSSALPK
     LSNLANLTTG AIARTSAGFV LMPITVIKVR YESNMYAYNS IIGASKDILK TDGIRGFFAG
     FGATAVRDAP YAGLYVLFYE QFKKRMSRVV QNVGVPGAPE MAMAGGTSAS INFGSGVVAA
     GLATAITNPF DSIKTRIQLR PREYRNMVQA ARKMVTEEGV RSLFDGLGIR MARKAMSSAL
     AWTLYEELIR RAELPWKDRS EKSLS
//