ID A0A094MIV4_ANTCR Unreviewed; 430 AA.
AC A0A094MIV4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Legumain {ECO:0000256|ARBA:ARBA00021147};
DE EC=3.4.22.34 {ECO:0000256|ARBA:ARBA00012628};
DE AltName: Full=Protease, cysteine 1 {ECO:0000256|ARBA:ARBA00030799};
DE Flags: Fragment;
GN ORFNames=N321_04262 {ECO:0000313|EMBL:KFZ53265.1};
OS Antrostomus carolinensis (Chuck-will's-widow) (Caprimulgus carolinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Caprimulgiformes;
OC Caprimulgidae; Antrostomus.
OX NCBI_TaxID=279965 {ECO:0000313|EMBL:KFZ53265.1, ECO:0000313|Proteomes:UP000053620};
RN [1] {ECO:0000313|EMBL:KFZ53265.1, ECO:0000313|Proteomes:UP000053620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N321 {ECO:0000313|EMBL:KFZ53265.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins and small molecule substrates at
CC -Asn-|-Xaa- bonds.; EC=3.4.22.34;
CC Evidence={ECO:0000256|ARBA:ARBA00000810};
CC -!- SIMILARITY: Belongs to the peptidase C13 family.
CC {ECO:0000256|ARBA:ARBA00009941}.
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DR EMBL; KL341652; KFZ53265.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094MIV4; -.
DR Proteomes; UP000053620; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IEA:InterPro.
DR CDD; cd21115; legumain_C; 1.
DR Gene3D; 1.10.132.130; -; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR043577; AE.
DR InterPro; IPR048501; Legum_prodom.
DR InterPro; IPR046427; Legumain_prodom_sf.
DR InterPro; IPR001096; Peptidase_C13.
DR PANTHER; PTHR12000; HEMOGLOBINASE FAMILY MEMBER; 1.
DR PANTHER; PTHR12000:SF42; LEGUMAIN; 1.
DR Pfam; PF20985; Legum_prodom; 1.
DR Pfam; PF01650; Peptidase_C13; 1.
DR PIRSF; PIRSF500139; AE; 1.
DR PIRSF; PIRSF019663; Legumain; 1.
DR PRINTS; PR00776; HEMOGLOBNASE.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000053620};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..430
FT /note="Legumain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001902664"
FT DOMAIN 334..428
FT /note="Legumain prodomain"
FT /evidence="ECO:0000259|Pfam:PF20985"
FT ACT_SITE 148
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT ACT_SITE 189
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT NON_TER 430
FT /evidence="ECO:0000313|EMBL:KFZ53265.1"
SQ SEQUENCE 430 AA; 49032 MW; 62BF5A823EE698AA CRC64;
MILTAVVLLG CALGISTFPM EEPEDGGKHW VVIVAGSNGW YNYRHQADVC HAYQIVHRNG
VPDEQIIVMM YDDIADNDEN PTKGIVINRP NGTDVYAGVP KDYTKEDVTP KNFLAILRGD
AEAMKGVGSG KVLKSGPKDH VFVYFTDHGA PGLLAFPDDD LHVKDLNKTI WYMYRHKKYQ
KMVFYIEACE SGSMMNHLAD NINVYATTAA NPRESSYACY YDEERQTYLG DWYSVNWMED
SDMEDLRKET LHKQFQLVKK RTNTSHVMQY GNRSISSMKV MQFQGMGKKS TPVSLPPVEH
YDLTPSPDVP LAIMKRKLMA TNDIYEAKRI ATEMKIHLEV KEFIQESMRK IITLVTGSEE
QTKQILSDRL TISNYDCYQS AVNHFKAHCF NWHLAVYEYA LRQLYALVNV CEGGYSIDRI
CLAMDKVCLG
//
