ID   A0A094P612_9ACTN        Unreviewed;       289 AA.
AC   A0A094P612;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Serine hydroxymethyltransferase-like domain-containing protein {ECO:0000259|Pfam:PF00464};
GN   ORFNames=GM43_4910 {ECO:0000313|EMBL:KGA04864.1};
OS   actinobacterium acMicro-4.
OC   Bacteria; Actinomycetota; Actinomycetes.
OX   NCBI_TaxID=1504317 {ECO:0000313|EMBL:KGA04864.1, ECO:0000313|Proteomes:UP000029304};
RN   [1] {ECO:0000313|EMBL:KGA04864.1, ECO:0000313|Proteomes:UP000029304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Ghai R., Mizuno C.M., Picazo A., Camacho A., Rodriguez-Valera F.;
RT   "Key roles for freshwater Actinobacteria revealed by deep metagenomic
RT   sequencing.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGA04864.1}.
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DR   EMBL; JNSD01000013; KGA04864.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094P612; -.
DR   STRING; 1504317.GM43_4910; -.
DR   PATRIC; fig|1504317.4.peg.983; -.
DR   Proteomes; UP000029304; Unassembled WGS sequence.
DR   GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:InterPro.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:InterPro.
DR   CDD; cd00378; SHMT; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR001085; Ser_HO-MeTrfase.
DR   InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
DR   InterPro; IPR039429; SHMT-like_dom.
DR   PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11680:SF28; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR   Pfam; PF00464; SHMT; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00096; SHMT; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898}.
FT   DOMAIN          12..285
FT                   /note="Serine hydroxymethyltransferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00464"
SQ   SEQUENCE   289 AA;  30823 MW;  E35F2BDA2B6A4CBB CRC64;
     MSHIDKTFSQ SLAQVDPEIQ DVLDKELGRQ RGTLEMIASE NFVPHSVLEA QGSVLTNKYA
     EGYPGKRYYG GCEFVDIAEN LAIERAKKLF GAAYANVQPH SGASASAAVL HALAQPGDTI
     LGLELAHGGH LTHGMKLNFS GKVYNATAYG VDPTTFLIDM NRVRDAALEH KPRVLIAGWS
     AYPRHTDFAA FRAIADEVGA SLWVDMAHFA GLVAAGVHPS PIPYADVVSS TVHKTLGGPR
     SGIILSRDES LAKKLNSAVF PGQQGGPLMH VIAAKAVAFK LAMEPADGR
//