ID A0A094ZD16_SCHHA Unreviewed; 1820 AA.
AC A0A094ZD16;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=MS3_00289 {ECO:0000313|EMBL:KGB32160.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB32160.1};
RN [1] {ECO:0000313|EMBL:KGB32160.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; KL250494; KGB32160.1; -; Genomic_DNA.
DR RefSeq; XP_012791939.1; XM_012936485.1.
DR STRING; 6185.A0A094ZD16; -.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KGB32160.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1212..1398
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1542..1804
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 552..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1498..1551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..820
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1507..1551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1820 AA; 203609 MW; 522258B0C30FBA53 CRC64;
MYLNAVYCLG HMGVVLAQMP HTQELILQFL QQNLNPAKLL PQLEIKSMEQ LGCMVIGGSS
VVYDQIMDIL TAIRVRSTRE MALNPQMKNS RLRQLSEAMI NVFANISTFV QGQPKLYKLL
HRLLEHYVHV DMELDQDSKS TSILTIAAHG LGQLIPVIAI LLKRLSPIQN PNQRLQKLFR
EFWLSVTVMG FADPNSTIWP VEYYRGLCEI AIKSPVLLLN DSLRAELQQS SALSPRNLSQ
IDVTDIRNKL CILLDNNAET TSLINRMSVT QCIYLMAVYR LESLCIGHSS DPEALHRLFM
YLEDNIIIKD KFGMWTCISQ VAVRIFTRYL AQMKAKPLDI VRESIMDMHA QFLLVMFTRI
HKSLRIVADE FLSMLAKDFP HVMWSGRVLF TMLDVAQLLS QSLEVDPNLT APVYNVPGTN
FKLFTSDSLP AREKMLTDFV KRCKGIIEVG LQWAPNLVRS HLINYMLEIQ HPSTDLPQHT
GLALATESVL NYAGYNRSAS FLGTSALDKR PTCAKMDSSN FMYNLILRNR YLGEVSNVYL
TSRLSKMLTN LEESQPKSKQ QQLLKSSLSS SNNNTSNNLL VNETTEQIKR LQNQKSIALD
VVQACLFLTT TMTVSTTGNP NSSCHLINDT KNPTTIDITS TTITSSRKKL YVMKGDTARR
LLQEICHSPL RLFTTEMLEN ALACWQWLIV GRPELTIQLL NELSDAWQIT IHRRLGVFSV
HNADDGEVLP LIVSDQIKYS PPKCNTGPHQ LWSQFFSERL YVAQSSSQEQ LDIFFDLLQK
TLAGEIASLN KSIHTVQNSS ETSKNSQKPH SRRHDHPSSI IRGRLTNNVA ALGVRCRLVE
MCLSLLQNTG FKSNYSGGQG ISTDELSSHV GGVMTAATIT TGTGGGVGSS GGSVVSAGGR
TGGSSGSQGQ IDTGCLFPLA RIALREKAYA TILNYFTVKP QYPIKHDADL SDELKALSRL
WSLMQAERKY LNTSMIETEM DALLEAVGRG GFIVGSDFDY GAVYLSDQMT VNTPESIAVG
GGVVGASIGS SGFPTNPMST VTTTYHTTSS SPNIRHVNSN VFTESWITSN VTTMTTTSIT
SGGATLPRLR SQVMLLTDQP LERPGVGSLI LPSALNSTTS PTLQNAAVLA GTNIAHSVVS
KRSSATGGKQ SARTNGENYL KQIFLQKREL ILILLASEIE RLSVWFNPQG LSDRIGIREA
EVETWLRETL RKKSWRRWIS LAWDLCPPVA VYMPQRFTGS DELRREVSLF VTANPLLVTH
IPAALQYLAT SSNIEDGRPE LSHILTWSPV APVVALSFFS RMYPQHPLTH QYAVRVLSDY
PSETMLFYVP QFVQGIRYDK LGYLSESIVT LAKRSPLLAH QLLWNMKTNI YRDEESLKFD
NEIGEARKKA CLEALREVNV KPGCYLPSNP DSVVLEIDYM SGTPMQSAAK APFLARFKVR
RVGVQNLETE AINAAKEAKN LTTIPDDPSS QHMHHHRDSI DGINPVVKML SQAGIKYRRR
NSHHESPNSP SRQTLASVPH KYSTVASRAN KIRQPTASGG STTNPTDDKQ LTTSTKLGHV
FMQACIFKVG DDVRQDILAL QILQLFKNIF ERCGLELFVY PYKVVATAPG RGVIECVPDS
KSRDQIGRQI DGKLYEYFLS IYGDETNPSY QTARRNFTLS LAAYSVFLYL IQIKDRHNGN
IMIDKVGHII HIDFGFMLES SPGGNLGWES DMKLSKEMFM IMGGRMDSPS YLWFEHLSIQ
AYLALRPYQE CIVSLISLML DSGLPCFRGQ TIKLLRQRFA PQLSDREAAA SYLRIIRTCL
AHWRDKSYDV LQYMQNQIPY
//
