ID   A0A094ZT82_SCHHA        Unreviewed;       725 AA.
AC   A0A094ZT82;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=GPN-loop GTPase 3 {ECO:0000256|ARBA:ARBA00014587};
DE   AltName: Full=ATP-binding domain 1 family member C {ECO:0000256|ARBA:ARBA00029702};
GN   ORFNames=MS3_05742 {ECO:0000313|EMBL:KGB37412.1};
OS   Schistosoma haematobium (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB37412.1};
RN   [1] {ECO:0000313|EMBL:KGB37412.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22246508; DOI=10.1038/ng.1065;
RA   Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA   Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA   Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA   Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA   Wang J., Gasser R.B.;
RT   "Whole-genome sequence of Schistosoma haematobium.";
RL   Nat. Genet. 44:221-225(2012).
CC   -!- FUNCTION: Small GTPase required for proper localization of RNA
CC       polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC       nuclear import. {ECO:0000256|ARBA:ARBA00002411}.
CC   -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC       {ECO:0000256|ARBA:ARBA00005290}.
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DR   EMBL; KL250881; KGB37412.1; -; Genomic_DNA.
DR   RefSeq; XP_012797174.1; XM_012941720.1.
DR   AlphaFoldDB; A0A094ZT82; -.
DR   STRING; 6185.A0A094ZT82; -.
DR   EnsemblMetazoa; XM_012941720.2; XP_012797174.2; MS3_0017439.
DR   GeneID; 24593177; -.
DR   KEGG; shx:MS3_00008041; -.
DR   CTD; 24593177; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR   CDD; cd17872; GPN3; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   HAMAP; MF_01547; RNA_methyltr_E; 1.
DR   InterPro; IPR004130; Gpn.
DR   InterPro; IPR030228; Gpn3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR   InterPro; IPR015507; rRNA-MeTfrase_E.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR007404; YdjM-like.
DR   PANTHER; PTHR21231:SF7; GPN-LOOP GTPASE 3; 1.
DR   PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR   Pfam; PF03029; ATP_bind_1; 1.
DR   Pfam; PF01728; FtsJ; 1.
DR   Pfam; PF04307; YdjM; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        405..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          498..716
FT                   /note="Ribosomal RNA methyltransferase FtsJ"
FT                   /evidence="ECO:0000259|Pfam:PF01728"
SQ   SEQUENCE   725 AA;  82500 MW;  84826591336F957F CRC64;
     MPRFAQLVIG PAGCGKSTYC STMQAHCETL RRKVDVVNLD PAAEFFEYTP LADIRDLIHL
     DDVMEDEAIR LGPNGGLIFC LEYLQQNLNW LDTALGDIDG DYLLFDCPGQ IELYSHLPIM
     PRIIEYMQRK WDFRFVTIFI LDARFLVDSS HFLAGVLSAL SAMVSLSTAH INVMSKLDLL
     SEQKQKYVMA RYLNPDMDYF FDLDQVFDEE DGGEHHEKEA PFNKLTHALA DLIERYSVVH
     FVPLNRDKED TITDLLVQID QCLQYDEEVD PSNRAFDDAE QELCKSVNSG SHTHLFLETL
     THGLTGSMFW LCCLISINGK LDLYTTGYRK NIIMTLESCF WAAFGAILPD IDHFIASGST
     SIELARQLPG RPFLHWAGLY LLIYTLLIIG LFFISYPICL KFNRFFTIFW CFIFIPFISH
     IIRDANKRGL WLWPPPDFYT LMNLSNFTYN ILYPSNPGMI HLIRTLLLYL VVLMFIILRW
     IARQRSDPYV KRAHLESYRC RSAFKLLQLN DKISGGIFKP GDIVVDCGAA PGSWCQVASS
     LTNCNNNFKA SNNQNKGLVV GLDLLNFAPL PGVITYCGVD LNNWSECINL INQSISNHFN
     NNDNGRKPLQ SERQKSLPGV DIVLSDIAPN VSGMREIDIP AMMTLAYNIL RVAISVSKEG
     ASFVIKLFES AEAEEFKQTV SQFYTLNSKC SSFTRFIKPE ASRKESSEIY LVARGFQLPQ
     SRQDS
//