ID A0A095APN4_SCHHA Unreviewed; 939 AA.
AC A0A095APN4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Octopamine receptor 2 {ECO:0000313|EMBL:KGB36226.1};
DE SubName: Full=Putative 5-hydroxytryptamine receptor {ECO:0000313|EMBL:KAF1315387.1};
GN ORFNames=MS3_00005539 {ECO:0000313|EMBL:KAH9588003.1}, MS3_0013404
GN {ECO:0000313|EMBL:KAF1315387.1}, MS3_04518
GN {ECO:0000313|EMBL:KGB36226.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB36226.1};
RN [1] {ECO:0000313|EMBL:KGB36226.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAF1315387.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9588003.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9588003.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMPZ02000599; KAF1315387.1; -; Genomic_DNA.
DR EMBL; AMPZ03000003; KAH9588003.1; -; Genomic_DNA.
DR EMBL; KL250755; KGB36226.1; -; Genomic_DNA.
DR RefSeq; XP_012795996.1; XM_012940542.1.
DR AlphaFoldDB; A0A095APN4; -.
DR STRING; 6185.A0A095APN4; -.
DR EnsemblMetazoa; XM_012940542.1; XP_012795996.1; MS3_0013404.
DR GeneID; 24592045; -.
DR KEGG; shx:MS3_00005539; -.
DR CTD; 24592045; -.
DR OrthoDB; 2903324at2759; -.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd14967; 7tmA_amine_R-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR PANTHER; PTHR24247:SF241; DOPAMINE RECEPTOR 2-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 2.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 2.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:KGB36226.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000471633};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 838..858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..892
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 489..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 939 AA; 106701 MW; E861B7ABC4BB6236 CRC64;
MEISVTYSNW AFVIISIIFL FITLLTAVGN ALVFAALFRF RKLRTTSNLL IGNLALSDLL
LAVTVLPISA ATDATGVWLF GPVMCDIWLT IDVFYCTASV WSLVTIAFDR FTATTFPIWY
RGNKNKRRVI CYILFVWILS GLICVPGLLG WGSKAFDKAQ NNTSTISIPY STSTIRQNLN
EHKSNKSTLS STNTHVYNPT LNHYECVLFT EAYYIVYSAM GSFIIPFIIM IILYAKIFLI
LQQRTRLIRQ SRRIHNKSPP ECMIVHDKQF NGQSVDKINN YTTEKNLLTS PNTNTSIIHS
ITTTKPVLTN IKIAVDKPSS NSIIHEKRAN NNTHKTNEII QHSFYPSMYG SPSGSSTYSY
SYCYCSTCTC SCTCCHCGRE CHCFHLTTTT TTISSNKNTN TDSTADWNPR HMRNLNDLIG
MENNTVVNKL TNKINPRSVV NEMSSFDQII QQNTSKFTLK ATMNNNCSTT SSMKSQSSKT
SLSSSIAGSF TSSSLSRQSS FQTNRQNMKL EKLSFQNKLR NKMTPMSKNN IGKNSLSSLS
PMPPASLPQT FSPHHCHNCL LVDRQKLYLA SHLVGLDIAN ELDSLVNLKD KNNNNNCNYV
DEKVNNSGKP KNSNGTIQLD SEVNHVITKA NNDDYDDLNG HTHSDERTED MIHAYNLHNP
IPFITTEPIN IITSTCINTN SIDSITMTNT GIIHKDKYKP NILKKFTLFN CAQKHHDQNN
EEGISISHQS NDQLCSPDRL KTTSSIDLEY QHHYQQQQQP KMQQLEITSC YKQHDDRRIV
GVTNASTISD ITPPSMEPLQ LNERQQQHYY VNRSKQSNQS DQVMERVEQR ERRATKRMGL
IIIIFALSWI PFTLMYLVRG LCGEQFCPDI SDLRKFVTWL GYVNSTINPI LYALFNVHFR
QAFIYFLKCT HIKSHERQQR HQNSTLTKPP PSPPPPDQR
//
