ID A0A095C150_SCHHA Unreviewed; 611 AA.
AC A0A095C150;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN ORFNames=MS3_00006175 {ECO:0000313|EMBL:KAH9584651.1}, MS3_0016716
GN {ECO:0000313|EMBL:KAF1334633.1}, MS3_03509
GN {ECO:0000313|EMBL:KGB35263.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB35263.1};
RN [1] {ECO:0000313|EMBL:KGB35263.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAF1334633.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9584651.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9584651.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280815}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AMPZ02000230; KAF1334633.1; -; Genomic_DNA.
DR EMBL; AMPZ03000004; KAH9584651.1; -; Genomic_DNA.
DR EMBL; KL250670; KGB35263.1; -; Genomic_DNA.
DR RefSeq; XP_012795028.1; XM_012939574.1.
DR AlphaFoldDB; A0A095C150; -.
DR STRING; 6185.A0A095C150; -.
DR EnsemblMetazoa; XM_012939574.2; XP_012795028.1; MS3_0016716.
DR GeneID; 24591109; -.
DR KEGG; shx:MS3_00006175; -.
DR CTD; 24591109; -.
DR OrthoDB; 2996078at2759; -.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR24044:SF420; NEUROGENIC LOCUS PROTEIN DELTA; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 2.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 3.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW ECO:0000256|RuleBase:RU280815};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000471633};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..611
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038207382"
FT TRANSMEM 374..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 178..219
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 221..258
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 260..299
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 325..362
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 498..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 180..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 210..219
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 230..247
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 289..298
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 333..350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 352..361
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 611 AA; 69103 MW; 2E05449A5BB910D0 CRC64;
MNPSYFLIIL LYKFFYIGIL SSQIHSDNQP YGGAQLKIEW DYNNPASLLE NGQICDRVGG
KECDVYFTLC LKNAASVTDD IDKCHLLQHT TRIFDNAGYL EFRESDGIEI FVPQPVPNEY
TFTLGIFEQD IFGSVEVIGT LVANHFSLLP TNNWTNIRMS RENDQYKNTI YVNVRMRLSC
VKDYYGNHCH IFCKPEPSRY TCSSDGSYIC LPGLRGPKCD KEDSCFYEPC ADHATCVNKD
DESGRICLCN GQEKPECYPN YNPCDSKPCQ NGGECQLAGH YNESYICHCT EQWTGHKCNE
RRSACLEEAA KVQRNNNLST DHYNNSTEVT SVCLNGGTCF DHPIRFEVRC VCLPGWIGVR
CEIPVEIETA KSNWILITLI SVGVVLFITV VLLTIGVIWK CFIRKRKVQY LNKHGPIVLY
HNPRSSAQSN YGSSCPLNQH FMNITYEDTS NIPPLIKKSS NAAYSKQLEP STIPDEYDEC
DPLGIYSGTG IYETGFPPDE NTEGIDNKNN PLTTTGRISD PFDENAPPLP DRSETYGSPS
IQMVYDFNQS MDKKRPQSPS NSSTFTNNFN DSTTYRSIMK HDHITNVSAI NSPVFENRPK
IYRRTSSVCD A
//
