ID A0A095CZ20_CRYGR Unreviewed; 690 AA.
AC A0A095CZ20;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Integrin alpha N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CNBG_0389 {ECO:0000313|EMBL:KGB74551.1};
OS Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii)
OS (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=294750 {ECO:0000313|EMBL:KGB74551.1, ECO:0000313|Proteomes:UP000029445};
RN [1] {ECO:0000313|EMBL:KGB74551.1, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB74551.1};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2] {ECO:0000313|EMBL:KGB74551.1, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB74551.1};
RX PubMed=29507212;
RA Yadav V., Sun S., Billmyre R.B., Thimmappa B.C., Shea T., Lintner R.,
RA Bakkeren G., Cuomo C.A., Heitman J., Sanyal K.;
RT "RNAi is a critical determinant of centromere evolution in closely related
RT fungi.";
RL Proc. Natl. Acad. Sci. 115:3108-3113(2018).
CC -!- SIMILARITY: Belongs to the TIP family. {ECO:0000256|ARBA:ARBA00006496}.
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DR EMBL; CP025762; KGB74551.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A095CZ20; -.
DR VEuPathDB; FungiDB:CNBG_0389; -.
DR HOGENOM; CLU_020272_1_0_1; -.
DR OMA; PGDWIPW; -.
DR Proteomes; UP000029445; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR024881; Tip.
DR PANTHER; PTHR13412:SF0; T-CELL IMMUNOMODULATORY PROTEIN; 1.
DR PANTHER; PTHR13412; T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG; 1.
DR Pfam; PF13517; FG-GAP_3; 2.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..690
FT /note="Integrin alpha N-terminal domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001906039"
FT TRANSMEM 644..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 690 AA; 75537 MW; 60C981D413181A77 CRC64;
MRHSSLALLY PLLLLSPPAC ALWPFKEKRF KDEAFINAGS LGLGKLGGRI AAVGDWDGDS
KLDLFTLSDE AKTVQIHLWN GDKYKYIPSH TLSLSERIIN VVPGDYNHDG HLDLLLMYDK
SEGGGWWGSK VERLGMGVYL GGGPDGGFQE ESWTLPLSTA SQPMVYDADG SLRPSLLGYQ
HTEAGEGVVS WRNNGTGFTL DTPQLRPLDE ICIMANPHSS AFIDIDGDCL PDLVLHCTRS
NSVSFIQIWI NRGDAGYILA RSYDLPPGSG PISFADTNRD GSIDIIFPTC TRKSASTGLG
RDCSINIAHN KQVPLCSTEV SQWNTDGLLR CRGWGDMCLS HEKFEFSFDE SDPFFTSIPL
SELISDSSNP GILLHAPSDP SIPLPLRPGD FNVDGFPDFL FVTSNGTKSS RSTQVKILEN
VPCAKGIIGC KKGVKRGWRL GHGKGWDALE GITDAVGASW LDLDEDGSLD IMVQRSGDQI
GHKVTFIQNN FYHDAFFLKT EVLNGVCDGK CEPMAGGKSY NPLGVSYSGA TYKFTVLDTA
GHRVAQQVAQ LPQTGYHALQ TPYTFFGLGR TNNYVEKLFI GASLAPPNHI TFLESLIPNS
QVIINPPYPA AISSPDEKIE EPRSPVKTRS TEWKSQLYLK PGEWVPWVGA AVLGTVIALG
AVVLGLNERE KREDERDRQR ALHAINFQAL
//
