ID A0A096LWK8_POEFO Unreviewed; 1976 AA.
AC A0A096LWK8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=EMAP like 6 {ECO:0000313|Ensembl:ENSPFOP00000023549.1};
GN Name=EML6 {ECO:0000313|Ensembl:ENSPFOP00000023549.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000023549.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000023549.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR EMBL; AYCK01017941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01017942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01017943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01017944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01017945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01017946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01017947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01017948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01017949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01017950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000023549; -.
DR Ensembl; ENSPFOT00000028049.1; ENSPFOP00000023549.1; ENSPFOG00000023728.1.
DR eggNOG; KOG2106; Eukaryota.
DR GeneTree; ENSGT00940000155564; -.
DR OMA; DYTTKMY; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 7.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF33; HELP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 2.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 11.
DR SMART; SM00320; WD40; 28.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 5.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 3..48
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 250..265
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 382..462
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 405..436
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 559..591
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 669..717
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1226..1258
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1350..1410
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1721..1742
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1753..1826
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 1941..1976
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 599..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1266..1291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..632
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1276..1291
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1976 AA; 218700 MW; 7B5E0FC6756D670A CRC64;
MSERSAPGCR LRLDWVYGYR GHQCRNNLFY TAGKELVYFV AGVGVVYNTR EHSQRFYLGH
NDDIISLALH PERLLVATGQ VGRDPYVCVW DSFTAQTVSL LRDGHTHGIA CLGFSADGQR
LVSVGLDAKN TVCIWEWRKG KILASASGHS DRIFDVCWDP FQQNRLVSCG VKHIKFWSLC
GNALTPKRGI FGKTGDLQTI LCVASAKDDV TYSGALNGDV YVWRGLTLLR TVQSAHGAGI
FSLFSCEEGF ATGGRDGCIR LWDVDFKPVT KIDLREAEQG YKGLSIRSVC WRADRILAGT
QDSEIFEVMV RERDKPLLIM QGHSEGELWA LDVHPKKPLA VTGSDDRSVS RLWSLVDHAL
IARCNMEEAV RSVAFSLDGS QLALGMKDGS FTVLRVRDMT EVVHIKDRKE VIHEMKFSPD
GAYLAVGSND GLVDVYAVAQ RYKKVGECSK STSFITHLDW TVDGKILQSN DGAGERLFYW
MPMGKPITNE EVKGQRWASW SSVLGSEVSG IWPKYSDSTT VNAVDANLSA GVLVSGDDLG
LVKLYRFPCL RKGAKFKKYL GHSAHVTNVR WSSDLQSVLT TGGADHALFQ WRFLPEDGTG
GAPDGNTAES LGDSNSEESD SDASDVPELD SDIEQETQIN YERQVVYKED LPQLQQQSRE
KKQQVGSLKR QSGPDQGLRL QFVHGYYRGY DCRNNLFYAQ SGEVVYHVAA VGVVYNRQLH
SQRFYLGHDD DILSLSIHPL KDYAATGQVG RDPAVHVWDV QTLKCLSLLR GQHQRGVCAL
DFSADGKTLV SVGVDDEHSI VVWDWKRGEK LATARGQKDK IFVVKCNPVM MDRLVTVGIK
HIRFWQQQPG RGGLTFRRGA FRSVGRPETM MSVCYGRSEA LVFSGAANGD VYIWKEPILL
KTVKAHDGPV FAMFSLDKGF VTGGKDGVVE LWDDMFDRCL KTYAIKRTAL SPGSKGLLLE
DNPSIRAITL GHGHILVGTK NGEVLEIDKT GPMTLLVQVG ALGINWLLSS SRLCPGCVQV
SVLPTQTRFQ VPTQTRVLVP TQTRFSPGLS PRSESFYKQN RQIKQGSVSF HRKGIKVSSL
SFLSDPGKYL AVASHDSFVD IYHVLSTKRV GICKGASSYI THIDWDARGK LLQVNTGAKE
QLFFEAPRGR RQTIQNSELE RVDWSSWTCV LGSSCEGIWP THSDITDINA ASLTRDRTLL
ATGDDFGFLK LFSYPVQGQF ARFKRYVGHS AQVTNVRWAQ DDSALLTVGG ADTALMVWAR
ERGGGVSREL DPLPGADSEE SEDDIEEDGG YDSDVAREKT VDYVTKMFAV SIREMRGTKP
HQQLKELSAE ERDDGWMMDG CVRLCRPPVS RAAKQPEKLQ RNNVSKKKRL VEDLVLDHVF
GFRGFDCRNN LHYLNDGSDI VYHTAATAIV HSLSAGTQSF YLEHTDDILC LTVNQHPKYK
NIIASGQIGD VGEIPGTNPS IHVWDAMSKQ TLSVLRSSHA KGVGYVNFSA TGKLLLSVGV
EPEHTITVWR WQEGSRVCSK AGHPDRIFVV EFRPDSDSQF VSVGIKHVKF WTLAGGALMY
KKGVVGSVED GRMQTMLSVA FGANNLTFTG AINGDVYVWR HHFLLRLVAK AHTGPVFTMY
TTLRDGLIVT GGKERPTKEG GAVKLWDQEM KRCRAFQLET GQQVECVRSV CRGKGKILVG
TKDGEILEVG EKNAASNLLL DSHGRGGIWG LAAHPVKELC VTASDDATIR LWDLSDKKLL
NKVCVGHAAR CVSFSSDGEM LAVGMKNGEF LLLLANSLKI WTKKRDRSAG LQDIRFSPDR
RLLAVGSVEN TVDVYDMSGG PVLPRLVYCS DIPAFILQLD FSADSGYIQV STGAYRRLVF
EVPSGKLLSD QSAVDRITWA TWTSILGDEV LGIWPRSADR ADVICACVSH AGLNVVSGDD
LGLVRLFDFP CSDKFAKHKR FLGHSPHVTN IRFSHDDQHV VSTGGDDCSV FVWKCL
//
