ID A0A096MLA7_PAPAN Unreviewed; 1365 AA.
AC A0A096MLA7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Crumbs cell polarity complex component 1 {ECO:0000313|Ensembl:ENSPANP00000000319.3};
GN Name=CRB1 {ECO:0000313|Ensembl:ENSPANP00000000319.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000000319.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000000319.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000000319.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSPANT00000009705.4; ENSPANP00000000319.3; ENSPANG00000006812.4.
DR GeneTree; ENSGT00940000155152; -.
DR HOGENOM; CLU_000827_2_2_1; -.
DR Proteomes; UP000028761; Chromosome 1.
DR Bgee; ENSPANG00000006812; Expressed in iris and 61 other cell types or tissues.
DR ExpressionAtlas; A0A096MLA7; baseline.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 14.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 17.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00008; EGF; 13.
DR Pfam; PF12661; hEGF; 4.
DR Pfam; PF02210; Laminin_G_2; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 17.
DR SMART; SM00179; EGF_CA; 17.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 8.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 11.
DR PROSITE; PS50026; EGF_3; 17.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1365
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035323951"
FT DOMAIN 70..108
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 110..146
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 148..184
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 186..222
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 224..260
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 262..299
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 301..337
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 339..395
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 397..439
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 441..481
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 485..670
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 672..708
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 714..885
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 887..923
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 950..1137
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1139..1175
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1177..1212
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1214..1250
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1260..1295
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1297..1333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 79..96
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 98..107
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 136..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 174..183
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 212..221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 250..259
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 327..336
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 385..394
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 471..480
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 698..707
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 913..922
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1165..1174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1181..1191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1202..1211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1240..1249
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1285..1294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1323..1332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1365 AA; 149544 MW; D99460AC6564D025 CRC64;
MALKNINYLL IFYLSFSLLI YIKNSFCNKN NTRCLSNSCQ NNSTCKGFSK DNDCSCSGTA
NNVDKDCDDV KDPCFSNPCQ GSATCVNTPG ERSFLCKCPP GYSGTICETT IGSCGKNSCQ
HGGICHQDPI YPVCICPAGY AGRFCEIDHD ECASSPCQNG AVCQDGIDGY SCFCVPGYQG
RHCDLEVDEC ASDPCKNEAT CLNEIGRYTC ICPRDYSGIN CELEIDECWS QPCLNGATCQ
DALGAYFCDC APGFLGDHCE LNIDECASQP CLHGGLCVDG ENRYSCNCTG SGFTGTHCET
LMPLCWSKPC HNNATCEDSV DNYTCHCWPG YTGAQCEIDI NECNSNPCQS DGECVELSSE
KQYGHITGLP STFSYHEASG YVCICQPGFT GIHCEEDVNE CSSNPCQNGG TCENLPGNYT
CHCPFDNLSR TFYGGRDCSD ILLGCTHQQC LNNGICIPHF QDGQHGFSCL CPSGYTGSLC
EIATTLSFEG DGFLWVKTGS ATTKGSVCNI ALRFQTVQPV ALLLFRGNRD VFVKLELLSG
YIHLSIQVNN QPKVLLYISH NTSDGEWHFV EVIFAEAVTL TLIDDSCKEK CISKAPSPLE
SDPSICAFQN SFLGGLPVGT TSDGVALLNF YNIPSTPSFV GCLQDIKIDW NHITLENISS
GSSLNVKAGC VRKDWCESQP CQSRGRCINL WLSYQCDCHR PYKGPNCLRE FVAGRFGQDD
STGYVVFTLD ESYGDTVSLS MFVRTLQPSG LLLALENSTY QYIRVWLEHG RLTMLTPNSP
KLVVKFVLND GNVHLISLKI KPNKIELYQS SQNLGFISAS TWKIQKGDVI YIGGLPDKQE
TELNGGFFKG CIQDVRLNNQ KLEFFPNSTN NVSLKPVLVN VTQGCPGDNS CKSNPCRNGG
VCHSLWDDFS CSCPAHTSGK ACEEVQWCGF TPCPHEAQCQ PVLQGFECIA NAVFNGQSSQ
ILFRSNGNIT RELTNITFGF RTRDANVIIL HAEKEPEFLN ISIQDSRLFF QLQSGNSFYM
LSLTSLQSVN DGMWHEVTLS MTDPMSQTSR WQMEVDNQTP FVTSTIATGS LNFLKDNTDI
YVGDGAIDNI KGLQGCLSTI EIGGIYLSYF ENVHGFTNRP QEEQFLKIST NSVVTGCLQL
SVCNSNPCLH GGNCEDIYSS YHCSCPLGWS GKHCELNTDE CFSNPCIHGN CSDRVAAYHC
TCEPGYTGGN CEVDIDNCQS HQCANGATCI SDTNGYSCLC FGNFTGKFCR QSTLPSTVCG
NEETNLTCYN GGNCTEFQAE LKCMCRPGFT GERCEKDIDE CASDPCVNGG LCQDLLNKFQ
CLCDVAFAGE RCEVDLMILL PNFTKKEKTE VIKREILQAA SLFPN
//
