ID A0A096MPT8_PAPAN Unreviewed; 3848 AA.
AC A0A096MPT8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Lysosomal trafficking regulator {ECO:0000313|Ensembl:ENSPANP00000001755.3};
GN Name=LYST {ECO:0000313|Ensembl:ENSPANP00000001755.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000001755.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000001755.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000001755.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 9555.ENSPANP00000001755; -.
DR Ensembl; ENSPANT00000001775.3; ENSPANP00000001755.3; ENSPANG00000016715.3.
DR eggNOG; KOG1786; Eukaryota.
DR GeneTree; ENSGT00940000156359; -.
DR HOGENOM; CLU_000213_1_0_1; -.
DR OrthoDB; 47483at2759; -.
DR Proteomes; UP000028761; Chromosome 1.
DR Bgee; ENSPANG00000016715; Expressed in thymus and 66 other cell types or tissues.
DR ExpressionAtlas; A0A096MPT8; baseline.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 3056..3162
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 3167..3469
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3659..3693
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1179..1206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1222..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2252..2275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3848 AA; 434408 MW; 5265B121D71F966C CRC64;
MSTDSNSLAR EFLTDVNRLC NAVVQRVEAR EEEEEETHMA TLGQYLVRGR GFLLLTKLNS
IIDQALTCRE ELLTLLLSLL PLVWKIPVQE EKATDFNLPL SADIILTKEK NSSSQRSTQE
KLHLEGSALS SQVSAKVNVF RKSRRQRKIT HRYSIRDARK TQLSTSDSEA NSDEKGITMN
KHRRPHLLQH FVTSFPKEDH PKAKLDHLTT KEEQTPPDTM ALENSREIIP RQESNTDILS
EPAALSVISN MNNSPFDLCH VLLSLLEKVC KFDITLNHNS PLAASVVPTL TEFLAGFGDC
CSLSDNLESR VVSAGWTEEP VALIQRMLFR TVLHLLSVDV STAEMMPENL RKNLTELLRA
ALKIRTCLEK QPDPFAPRQK KTLQEVQEDF VFSKYRHRAL LLPELLEGVL RILICCLQSA
ASNPFYFSQA VDLVQEFIQH HGFNLFETAV LQMEWLVLRD GVPPEASEHL KALINSVMKI
MSTVKKVKSE QLHHSMCTRK RHRRCEYSHF MHHHRDLSGL LVSAFKNQVS KNPFEETADG
DVYYPERCCC IAVCAHQCLR LLQQASLSST CVQILSGVHN IGICCCMDPK SVIIPLLHAF
KLPALKNFQQ HILNILNKLI LDQLGGAEIS PKIKKAACNI CTVDSDQLAQ LEETLQGNLR
DAEPSSSSST PSYRFQGILP SSGSEDLLWK WDALKAYQNF VFEEDRLHSI QIANHICSLI
QKGNIVVQWK LYNYIFNPVL QRGVELAHHC QHLSITSAQS HVCSHRNQCL PQDVLQIYVK
TLPILLKSRV IRDLFLSCNG VHQIIELNYL NGIRSHSLKA FETLIISLEE QQKDASVPGI
DGIDNEQKEL SSVHVGTSFH HQQAYSDSPQ SLSRFYAGLK EAYPKRRKTV NQDVHINTIN
LFLCVAFLCI SKEAESDREL ANDSEDTSGY DSTASEPLSH MLPCLSLESL ALPSPEHMHQ
AADIWSMCRW IYMLSSVFQK QFYRFGGFQV CHKLIFMIIQ KLFRSHKEEQ GKKEGDTTVN
ENQDLNRISQ PEITMKEDLL SLTIKSDPIP SELGSLKKSA DSLGKLELQH ISSMNVEQIS
ASEAAPEEAK IFTSQESETS LQSIRLLEAL LAICLHGART SQQKMELELP NQNLSVENIL
FEMRDHLSQS KVVETQLAKP LFDALLRVAL GNYSADFEHS DAVTEKSRQS AEELSSQPGD
FSEEAEDSQC CSFKLLVEEE GYEADSESNP EDGKTQDDGV DLKSETEGFS ASRSPNDLLE
NLTQGEIIYP EICMLELNLL SASKAKLDVL AHVFESFLRI IRQKEKNIFL LMQQGTVKNL
LGGFLSILTQ ADSDFQACQK VLVDLLVSLM SSRTCSEELT LLLRIFLEKS PCTKILLLGI
LKIIESDTTM SPSQYLTFPL LHTPNLSNGV SSQKYPGILN SKAMGLLRRA RVSRSKKEAD
RESFPHRLLS SWHIAPVHLP LLGQNCWPHL SEGFSVSLWF NVECIHEAES TAEKGKNIKK
RNKSLILPDS SFDGTGSDRP EGAEYINPGE RLIEEGCIHI ISLGSKALMI QVWADPHNAS
FIFRVCMDSN DDVKAVLLAQ VESQENIFLP SKWQHLVLTY LQQPQGKKKI HGKISIWVSG
QRKPDVTLDF MLPRKTSLSS DSNKTFCMIG HCLSSQEEFL QLAGKWDLGN LLLFNGAKVG
SQEAFYLYAC GPNHTSVMPC KYGKPVNDYS KYINKEILRC EQIRELFMTK KDVDIGLLIE
SLSVVYTTYC PAQYTIYEPV IRLKGQMKTQ LSQRPFSSKE VQSILLEPHH LKNLQPTEYK
TIQGILHEIG GTGVFVFLFA RVIELSSCEE TQALALRVIL SLIKYNQQRV HELENCNGLS
MIHQVLIKQK CIVGFYILKT LLEGCCGEDI IYMNENGEFK LDVDSNAIIQ DVKLLEELLL
DWKIWNKAED LTLSPRLKCS GAVLAHCNLC LSGSSSPPTS ASQVARTTCV HHHAWQGVWE
TLLAALEVLI RADHHQQMFN IKQLLKAQVV HHFLLTCQVL QEHKEGQLTP MPREVCRSFV
KIIAEVLGSP PDLELLTIIF NFLLAVHPPT NTYVCHNPTN FYFSLHIDGK IFQEKVQSIM
YLRHSSSGGR SLMSPGFMVI SPSGFTASPY EGENSSNIIP QQMAAHMLRS RSLPAFPTSS
LLMQSQKLTG SLGCSIDRLQ NIADTYVAIQ SEKQNSLGSS DTLKKGKEDA FISSCESAKT
VCEMEAVLSA QVSVSDVPKG VLGFPVVKAD HKELGAEPRP EDDSPGDESC PRRPDHLKGL
ASFQRSHSTV ASLGLAFPSQ NGSAAVGRWP SLVDRNTDDW ENFAYSLGYE PNYIRTARAH
SVTEDCLVPI CCGLYELLSG VLLILPDVML EDVMDKLIQA DTLLVLINHP SPAIQQGVIK
LLDAYFARAS KGQKDKFLKN RGFSLLANQL YLHRGTQELL ECFIEMFFGR HIGLDEEFDL
EDVRNTGLFQ KWSVIPILGL IETSLYDNIL LHNALLLLLQ ILNSCSKVAD MLLDNGLLYV
LCNTVAALNG LEKNIPVSEY KLLACDIQQL FIAVTIHACS SSGSQYFRVI EDLIVMLGYL
QNSKNKRTQN MAVALQLRVL QAAMEFIRTT ANHDSENLTD SLQSPSAPHH AIVQKRKSIA
GPRKFPLAQT ESLLMKMRSV ANDELHVMMQ RRMSQENPSQ ATETELAQRL QRLTVLAVNR
IIYQEFNSDI IDILRTPENV TQSKTSVFQT EISEENMHHE QSSVFNPFQK EIFTYLVEGF
KVSIGSSKAS GSKQQWTKIL WSCKETFRTQ LGRLLVHILS PAHTAQERKQ IFEILHEPNH
QEILRDCLSP SLQHGAKLVL YLSELIHNHQ DELTEEELDT AELLMNALKL CGHKCIPPSA
STKADLIKMI KEEQKKYETE EGVNKATWQK TVNNNQQSLF QRLDSKSKDI SKIAADITQA
VSLSQGIERK KVIQHIRGMY KVDLSASRHW QELIQQLTHD RAVWYDPIYY PTSWQLDPTE
GPNRERRRLQ RCYLTIPNKY LLRDRQKSED IVKPPLSYLF EDKTHSSFSS TVKDKAASES
IRINRRCISV APSRETAGEL LLGKCGMYFV EDNASDTVES SSLQGELEPA SFSWTYEEIK
EVHKRWWQLR DNAVEIFLTN GRTLLLAFDN TKVRDDVYHN ILTNNLPNLL EYGNITALTN
LWYTGQITNF EYLTHLNKHA GRSFNDLMQY PVFPFILADY ISETLDLNDP LIYRNLSKPI
AVQYKEKEDR YVDTYKYLEE EYRKGAREDD PMPPVQPYHY GSHYSNSGTV LHFLVRMPPF
TKMFLAYQDQ SFDIPDRTFH STNTTWRLSS FESMTDVKEL IPEFFYLPEF LVNREGFDFG
VRQNGERVNH VNLPPWARND PRLFILIHRQ ALESDYVSQN ICQWIDLVFG YKQKGKASVQ
AINVFHPATY FGMDVSAVED PVQRRALETM IKTYGQTPRQ LFHTAHVSRP GAKLNIEGEL
PAAVGLLVQF AFRETREQVK EITYPSPLSW IKGLKWGEYV GSPSAPVPVV CFSQPHGERF
GSLQALPTRA ICGLSRNFCL LMTYSKEQGV RSMNSTDIQW SAILSWGYAD NILRLKSKQS
EPPVNFIQSS QQYQVTSCAW VPDSCQLFTG SKCGVVTAYT NRFTSSTPSE IEMETQIHLY
GHTEEITSLF VCKPYSILIS VSRDGTCIIW DLNRLCYVQS LAGHKSPVTA VSASETSGDI
ATVCDSAGGG SDLRLWTVNG DLVGHVHCRE IICSVAFSNQ PEGVSINVIA GGLENGIVRL
WSTWDLKPVR EITFPKSNKP IISLTFSCDG HHLYTANSDG TVIAWCRKDQ QRLKQPMFYS
FLSSYAAG
//
