ID A0A096N7E0_PAPAN Unreviewed; 1298 AA.
AC A0A096N7E0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Receptor-type tyrosine-protein phosphatase F {ECO:0000256|ARBA:ARBA00044158};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRF {ECO:0000313|Ensembl:ENSPANP00000008446.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000008446.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000008446.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000008446.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR STRING; 9555.ENSPANP00000008446; -.
DR Ensembl; ENSPANT00000022687.4; ENSPANP00000008446.3; ENSPANG00000017083.4.
DR GeneTree; ENSGT00940000155060; -.
DR Proteomes; UP000028761; Chromosome 1.
DR Bgee; ENSPANG00000017083; Expressed in esophagus and 66 other cell types or tissues.
DR ExpressionAtlas; A0A096N7E0; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 5.
DR CDD; cd14626; R-PTPc-F-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF7; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 616..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..93
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 98..206
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 207..302
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 707..962
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 882..953
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 994..1240
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1171..1244
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 80..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1298 AA; 146491 MW; 2304ECA337FD88C6 CRC64;
MCVSTGSTTV RVSWVPPPAD SRNGVITQYS VAYEAVDGED RRRHVVDGIS REHSSWDLVG
LEKWTEYRVW VRAHTDVGPG PESSPVLVRT DEDVPSGPPR KVEVEPLNST AVHVYWKLPV
PSKQHGQIRG YQVTYVRLEN GEPRGLPIIQ DVMLAEAQWR PEESEDYETT ISGLTPETTY
SITVAAYTTK GDGARSKPKI VTTTGAVPGR PTVMVSTTAM NTALLQWHPP KELPGELLGY
RLQYCRADEA RPNTIDFGKD DQHFTVTGLH KGTTYIFRLA ARNRAGLELA WDPPVLAERN
GRIISYTVVF RDINSQQELQ NVTTDTHFTL SGLKPDTTYD IKVRAWTSKG SGPLSPSIQS
RTMPVEQVFA KNFRVAAAMK TSVLLSWEVP DSYKSAVPFK ILYNGQSVEV DGHSMRKLIA
DLQPNTEYSF VLMNRGSSAG GLQHLVSIRT APDLLPHKPL PASAYIEDGR FALSMPHVQD
PSLVRWFYIV VVPIDRVGGS MLAPRWSTPE ELELDELLEA IEQGGEEQRR RRRQAERLKP
YVAAQLDVLP KTFTLGDKKN YRGFYNRPLS PDLSYQCFVL ASLKEPMDQK RYASSPYSDE
IVVQVTPAQQ QEEPEMLWVT GPVLAVILII LIVIAILLFK RKRTHSPSSK DEQSIGLKDS
LLAHSSDPVE MRRLNYQTPG MRDHPPIPIT DLADNIERLK ANDGLKFSQE YESIDPGQQF
TWENSNLEVN KPKNRYANVI AYDHSRVILT SIDGVPGSDY INANYIDGYR KQNAYIATQG
PLPETMGDFW RMVWEQRTAT VVMMTRLEEK SRVKCDQYWP ARGTETYGLI QVTLLDTVEL
ATYTVRTFAL HKSGSSEKRE LRQFQFMAWP DHGVPEYPTP ILAFLRRVKA CNPLDAGPMV
VHCSAGVGRT GCFIVIDAML ERMKHEKTVD IYGHVTCMRS QRNYMVQTED QYVFIHEALL
EAATCGHTEV PARNLYAHIQ KLGQVPPGES VTAMELEFKL LASSKAHTSR FISANLPCNK
FKNRLVNIMP YELTRVCLQP IRGVEGSDYI NASFLDGYRQ QKAYIATQGP LAESTEDFWR
MLWEHNSTII VMLTKLREMG REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT
DARDGQSRTI RQFQFTDWPE QGVPKTGEGF IDFIGQVHKT KEQFGQDGPI TVHCSAGVGR
TGVFITLSIV LERMRYEGVV DMFQTVKTLR TQRPAMVQTE VKQTSLQGQG LGSSPAGNPR
LQLQFVHTGM CNHSCCQPFT WPAIGMVVCA YGPTYLGG
//
