ID A0A096NFJ4_PAPAN Unreviewed; 4520 AA.
AC A0A096NFJ4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Dynein axonemal heavy chain 11 {ECO:0000313|Ensembl:ENSPANP00000011692.3};
GN Name=DNAH11 {ECO:0000313|Ensembl:ENSPANP00000011692.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000011692.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000011692.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000011692.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR Ensembl; ENSPANT00000024120.3; ENSPANP00000011692.3; ENSPANG00000021596.3.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000158880; -.
DR HOGENOM; CLU_000038_3_2_1; -.
DR OMA; ICEHMAY; -.
DR Proteomes; UP000028761; Chromosome 4.
DR Bgee; ENSPANG00000021596; Expressed in heart and 33 other cell types or tissues.
DR ExpressionAtlas; A0A096NFJ4; baseline.
DR GO; GO:0097728; C:9+0 motile cilium; IEA:Ensembl.
DR GO; GO:0097729; C:9+2 motile cilium; IEA:Ensembl.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0120134; C:proximal portion of axoneme; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0060411; P:cardiac septum morphogenesis; IEA:Ensembl.
DR GO; GO:0035545; P:determination of left/right asymmetry in nervous system; IEA:Ensembl.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IEA:Ensembl.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR GO; GO:0007611; P:learning or memory; IEA:Ensembl.
DR GO; GO:0120229; P:protein localization to motile cilium; IEA:Ensembl.
DR GO; GO:0003356; P:regulation of cilium beat frequency; IEA:Ensembl.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF12; DYNEIN AXONEMAL HEAVY CHAIN 11; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761}.
FT DOMAIN 1892..2028
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2506..2651
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2851..2987
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1279..1306
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3324..3393
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4520 AA; 520488 MW; 804C250548B2D1BB CRC64;
MAAPVVAREA RDFREAPTLR LMSGAGLEAV GAVELEEEEE EEENEEEAAA RRARSFAQDV
RVRFLGGRLE MMLGFTEEKW SQYLESEDNR QILGEFLEST SPACLVFSVA AAGRLAASQE
IPRDANHKLV FISKKITESI GVNDFSQVVL FGGLPALSLG HVSAFLDEIL VPVLSNKNNH
KSWSCFTSQD MEYHIEVMKN KMYIFKGKMS RRTLLPIPTV AGKIDLDQNY SENKPPQSNE
RIILHAIESV IIEWSHQIQE IIERDSVQPL LNGLHLSPQA ELDFWMMRRE NLSCIYDQLQ
APIVLKMVKI LTTKQSSYFP TLKDIFLAVE NALLEAQDVE LYLRPLRRHI QCLQETEFPQ
IRILIAPLFH TICLIWSHSK FYNTPARVIV LLQEFCNLFI NQATAFLSPE DLLKGEIEES
LEKVQVAVNM LKTFRNCFFN YRKKLASYFM GSKLRPWDFQ SHLVFCRFDK FLDRLIKIED
IFVSTLEFEK LERLEFGGTK GAILNGQVHE MSEEFMELYK VFKQSTYDPS DCNNMEFESD
YVAFKSKTLE FDRRLGTIIC EAFFNCNGLE AAFKLLTVFG NFLEKPVVME IFSLHYSTLV
HMFNTELDVC KQLYNEHMKQ IERGHVVLNK NMPFTSGNIR WAQQVLQRLQ MFWSNFASLR
YLFLGNPDNA LVYQKYVEMT TLLDQFENHV YNEWKSNVDE ICELNLNQPL VKFSAINGLL
CVNFDPKLVA ILREVKYLLM LKKQDIPDSA LAIFNKRNTI LKYIGNLDLL VQGYNKLKQT
LLEVEYPLIE DELRAIDEQL TAATMWLTWQ DDCWGYIERV REATSELEHR VERTQSNVKV
IQQTMRAWAG CVLPPRREHR REVAFTLEDK GDLFTKKYKL IQEDGCKIHS LVEENRKLFK
ADPSLDNWKI YVEFIDDIVV EGFFQAIMHD LDFFLKNTEK QLKPAPFFQA QMILLPPEIV
FKPSLDREAG DGFYDLVEEM LCNSFRISAQ MNRIATHLEI KNYQNDMDNM LGLAEVRQEI
MNRVSNVINK VLDFRNTLET HAYLWVDDRA EFMKHFLLYG HAVSSDEMDA RANEDIPKQP
PTLEQFKEQI DIYEALYAQM SKFDDFRVFD SWFKVDMKPF KVSLLTIIKK WSWMFQEHLL
RFVIDSLNEL QEFIKETDAG LQRELNEGDH DGLVDIMGNL LAVRSRQRAT DELFEPLKET
ITLLESYGQK MPEQVYIQLE ELPERWETTK KVAAAVRQEV SPLHNAEVTL IRKKCILFDG
KQAEFRERFR CYAPLGFNAE NPYTALDKAN QELEALEEEM LQMQESTRLF EVALPEYKQM
KQCRKEIKLL KGLWDVIIYV RRSIDNWTKT QWRQINVEQM DVELRRFAKE IGSLNKEVRI
WDAYTGLEGT VKDMTASLRA ITELQSPALR DRHWHQLMKA IGVKFLINEA TTLADLLALQ
LHRAEDDVRR IVDKAVKELG TEKVINEISQ TWATMTFSYE VHYRTGIPLL KSDEQLFETL
EHNQVQLQTL LQSKYVEYFI EQVLSWQNKL NIADSVIFTW MEVQRTWSHL ESIFVCSEDI
RIQLVKDARR FDGVDAEFKE LMFKTAKVEN VLEATCRPNL YEKLKDLQSR LSLCEKALTE
YLETKRIAFP RFYFISSGDL LDILSKGARP KQVTHHLAKL FDSIADLQFE DNQDVSAHRA
VGMYSKEKEY VPFQAECECV GHVETWLLQL EQTMQDTVRH SITEAIVAYE EKPRELWIFD
FPAQVALTSS QIWWTTDVGI AFSRLEEGYE TALKDFHKKQ ISQLNTLITL LLGELPPGDR
QKIMTICTID VHARDVVAKL ISQKVVSPQT FTWLSQLRHR WEDTQKHCFV NICDAQFQYF
YEYLGNSPRL VITPLTDRCY ITLTQSLHLT MSGAPAGPAG TGKTETTKDL GRALGMMVYV
FNCSEQMDYK SIGNIYKGLV QTGAWGCFDE FNRISVEVLS VVAVQVKMIH DAIRNRKKRF
VFLGEAIALK PSVGIFITMN PGYAGRTELP ENLKALFRPC AMVAPDIELI CEIMLVAEGF
VDARALARKF IMLYTLCKEL LSKQDHYDWG LRAIKSVLVV AGSLKRGDKN RPEDQVLMRA
LRDFNMPKIV TDDIPVFLGL VGDLFPTLDV PRRRKLHFEQ MVRQSTLELR LQPEESFILK
VVQLEELLAV RHSVFVVGNA GTGKSKILRT LNRTYVNMKQ KPVWNDLNPK AVTTDELFGF
IHHATREWKD GKIVYSCFIG LFSSILREQA NLKNDGPKWI VLDGDIDPMW IESLNTVMDD
NKVLTLASNE RITLTPFMRL LFEIHHLRSA TPATVSRAGI LYVNPQDLGW NPYVASWIDR
RRHQSEKANL TILFDKYVPA CLDKLRTSFK TVTSIPESSL VQTICVLLEC LLTPENVPSD
SPKEVYEVYF VFACIWAFGG TLLQDQLSDY QADFSRWWHK EMKAVKFPSQ GTIFDYYVDH
KTKKLLPWAD KIAQFTMDPD VPLQTVLVHT SETTRLRYFM ELLLEKGKPL MLVGNAGVGK
TVFVGDTLAS LSQDYIVSRV PFNYYTTSAA LQKILEKTLE KKAGHNYGPG GNKKLIYFID
DMNMPEVDLY GTVQPHTLIR QHIDYGHWYD RQKLMLKEIH NCQYVACMNP MVGSFTINPR
LQRHFTVFAF NFPSLDALNT IYGQIFSFHF QQQAFAPSVL RSGPTLIQAT IAFHQTMMCN
FLPTAIKFHY IFNLRDLSNV FQGILFASPE CLKGPLDLIR LWLHESARVY GDKLIDTKDC
DLFQKKMLET AYKYFEGIDS HMLLQQPLIY CHFANRGKDP HYMPVKDWEV LKMILTETLD
NYNELNAAMH LVLFEDAMQH VCRISRILRT PQGCALLVGV GGSGKQSLSR LAAYLCGLEV
FQITLTEGYG IQELRVDLAN LYIRTGAKNM PTVFLLTDAQ VLDESFLMLI NDLLASGEIP
DLFSDEDVDK IISGIHNEVH ALGMVDSREN CWKFFLARVR LQLKIILCFS PVGHTLRVRA
RKFPAIVNCT AIDWFHAWPQ EALVSVSRRF IEETKGIEPL HKDSISLFMA HVHTTVNEMS
TRYYQNERRH NYTTPKSFLE QISLFKNLLK KKQNEVSKKK EHLVNGIQKL KTTASQVGDL
KARLASQEAE LQLRNHDAEA LITKIGLQTE KVSREKTVAD AEERKVTAIQ TEVFQKQREC
EADLLKAEPA LVAATAALNT LNRVNLSELK AFPNPPIAVT NVTAAVMVLL APRGRVPKDR
SWKAAKVFMG KVDDFLQALI NYDKEHIPEN CLKVVNEQYL KDPEFNPNLI RTKSFAAAGL
CAWVINIIKF YEVYCDVEPK RQALAQANLE LAAATEKLEA IRKKLVDLDR NLSRLTASFE
KATAEKVRCQ EEVNQTDKTI KLANRLVKEL EAKKIRWGQS IKSFEAQEKT LCGDVLLTAA
FVSYVGPFTK QYRQELVHCE WVPFLQQKVF IPLTEGLDLI SMLTDDATVA TWNNEGLPSD
RMSTENAAIL THCERWPLLI DPQQQGIKWI KNKYGTDLKV THLGQKGFVN AIETALAFGD
VILIENLEET IDPVLDPLLG RNTIKKGKYI RIGDKECEFH KNFRLILHTK LANPHYKPEL
QAQTTLLNFT VTEDGLEAQL LAEVVSIERP DLEKLKLVLT KHQNDFKIEL KYLEDDLLLR
LSAAEGSFLD DTKLVESLEA TKATAAEIEH KVIEAKENER KINEARECYR PVAARASLLY
FVINDLQKIN PIYQFSLKAF NVLFHRVIEQ ADKVEDMQGR ISILMESITH AVFLYASQAL
FEKDKLTFLS QMAFQILLRK KEIDPLELDF LLRFTIEHTH LSPVDFLTSQ SWSAIKAIAL
LEEFRGIDRD VEGSAKQWRK WVESECPEKE KLPQEWKKKS LIQKLIILRA MRPDRMTYAL
RNFVEEKLGA KYVERTRLDL VKAFEESSPA TPIFFILSPG VDALKDLEIL GKRLGFTIDS
GKFHNVSLGQ GQEMVAEMAL EKASKGGHWV ILQNVHLVAK WLGTLEKLLE RFSQGSHRDY
RVFMSAESAP TPDEHIIPQG LLENSIKITN EPPTGMLANL HAALYNFDQD TLEICSKEQE
FKSILFSLCY FHACVAGRLR FGPQGWSRNY PFNPGDLTIC ANVLYNYLEA NPKVPWEDLR
YLFGEIMYGG HITDDWDRQL CRVYLEEFMN PSLIEDELML APGFAAPPYL DYAGYHQYIE
EMLPPESPAL YGLHPNAEIE FLTVTSNTLF RTLLEMQPRN ALSGDELGQS TEEKVKNVLD
DILEKLPEEF NMAEIMQKNS HRSPYVLVCF QECERMNILI REIRVSLEQL DLSLKGELAL
SPALEAQQFA LSYDTVPDTW SKLAYPSTYG LAQWFSDLLL RCRELDTWTQ DLALPAVVWL
SGFFNPQSFL TAIMQTMARK NEWPLDKTCL TVDVTKKTKE DYGHPPREGA YLHGLFMEGA
RWDTQSGTIV EARLKELTCP MPVIFAKATP VERQETKQTY ECPVYRTKLR GPSYIWTFRL
KSEEKTAKWV LAGVALLLEV
//
