ID A0A096NGV9_PAPAN Unreviewed; 727 AA.
AC A0A096NGV9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Translation initiation factor IF-2, mitochondrial {ECO:0000256|ARBA:ARBA00044200};
GN Name=MTIF2 {ECO:0000313|Ensembl:ENSPANP00000012198.1};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000012198.1, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000012198.1, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000012198.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC and promotes its binding to the 30S ribosomal subunits. Also involved
CC in the hydrolysis of GTP during the formation of the 70S ribosomal
CC complex. {ECO:0000256|ARBA:ARBA00025162}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
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DR RefSeq; XP_009182469.1; XM_009184205.2.
DR RefSeq; XP_009182470.1; XM_009184206.2.
DR RefSeq; XP_009182471.1; XM_009184207.1.
DR RefSeq; XP_009182473.1; XM_009184209.1.
DR RefSeq; XP_009182476.1; XM_009184212.2.
DR RefSeq; XP_009182477.1; XM_009184213.2.
DR RefSeq; XP_017803028.1; XM_017947539.1.
DR RefSeq; XP_017803029.1; XM_017947540.1.
DR AlphaFoldDB; A0A096NGV9; -.
DR STRING; 9555.ENSPANP00000012198; -.
DR Ensembl; ENSPANT00000008538.4; ENSPANP00000012198.1; ENSPANG00000014549.4.
DR GeneID; 101022027; -.
DR KEGG; panu:101022027; -.
DR CTD; 4528; -.
DR eggNOG; KOG1145; Eukaryota.
DR GeneTree; ENSGT00900000141103; -.
DR OMA; DEIICFE; -.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000028761; Chromosome 14.
DR Bgee; ENSPANG00000014549; Expressed in optic disc and 65 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01887; IF2_eIF5B; 1.
DR CDD; cd03702; IF2_mtIF2_II; 1.
DR CDD; cd03692; mtIF2_IVc; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR HAMAP; MF_00100_B; IF_2_B; 1.
DR InterPro; IPR044145; IF2_II.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR000178; TF_IF2_bacterial-like.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF20; TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 2.
DR PROSITE; PS51722; G_TR_2; 1.
DR PROSITE; PS01176; IF2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761}.
FT DOMAIN 178..346
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT COILED 460..487
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 727 AA; 81568 MW; C316A4DCB5CCB699 CRC64;
MNQKLLKLEN LLRFHTIYRQ LHSLCQRRAL RQWSHGFSSA YPVWTAQLYA WPWPTEMLIG
AALSQYRFLV TKKEERPRKS QLSSTKSKKV VEVWIGMTVE ELARAMEKNT DYIYEALLNT
AIDIDSLEAD SHLDEVWIKE VIMKAGMKLK WSKLKQDKVK KNKDAVRRPQ ADPALLTPRS
PIVTIMGHVD HGKTTLLDQL RKTQVAAMEV GGITQHIGAF LVSLPSGEKI TFLDTPGHAA
FSAMRARGAQ VTDIVILVVA ADDGVMKQTV ESIQHAKDAQ VPIVLAINKC DKAEADPERV
KKELLAYDVV CEDYGGDVQA VPVSALTGNN LMALAEATVA LAEILELKAD PNGPVEGTVI
ESFTDKGRGP VTTAIIQRGT LRKGCVLVAG NCWAKVRSMF DENGKTIHEA HPSMPVGITG
WRDLPSAGEE ILEVESEPRA REVVDWRKYE QEQEKGKEDM KIIEEKRKEH QEAYQKAREK
YSNVQWKKRS LLRYLEIKEQ TSLKRKEEME RDSNVLPVII KGDVDGSVEA ILNIIDTYDA
SHECELELVH FGVGDISAND VNLAETFNGV IYGFNVNVGK VIQESAAKKG VKMKLHKIIY
RLVEDLQEEL SSRLPCAVEE HPVGEASILA TFSITEGKKK VPVAGCRVQK GQLEKQKKFK
LTRDGHVIWK GSLTSLKHHK DDISIVKTGM DCGLSLDEEN MEFKVGDRIV CYEEKQIQAK
TSWDPGF
//
