ID A0A096NL59_PAPAN Unreviewed; 964 AA.
AC A0A096NL59;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Lysine demethylase 1B {ECO:0000313|Ensembl:ENSPANP00000013717.2};
GN Name=KDM1B {ECO:0000313|Ensembl:ENSPANP00000013717.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000013717.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000013717.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000013717.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR AlphaFoldDB; A0A096NL59; -.
DR STRING; 9555.ENSPANP00000013717; -.
DR Ensembl; ENSPANT00000011865.3; ENSPANP00000013717.2; ENSPANG00000013806.3.
DR eggNOG; KOG0029; Eukaryota.
DR GeneTree; ENSGT00940000157751; -.
DR HOGENOM; CLU_007885_0_0_1; -.
DR OMA; AVYYDMD; -.
DR OrthoDB; 5402444at2759; -.
DR Proteomes; UP000028761; Chromosome 6.
DR Bgee; ENSPANG00000013806; Expressed in esophagus and 66 other cell types or tissues.
DR ExpressionAtlas; A0A096NL59; baseline.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000786; C:nucleosome; IEA:Ensembl.
DR GO; GO:0071949; F:FAD binding; IEA:Ensembl.
DR GO; GO:0140682; F:FAD-dependent H3K4me/H3K4me3 demethylase activity; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0044726; P:epigenetic programing of female pronucleus; IEA:Ensembl.
DR GO; GO:0071514; P:genomic imprinting; IEA:Ensembl.
DR Gene3D; 3.30.40.100; -; 1.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007526; SWIRM.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR011124; Znf_CW.
DR PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR PANTHER; PTHR10742:SF413; LYSINE-SPECIFIC HISTONE DEMETHYLASE 1B; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR Pfam; PF04433; SWIRM; 1.
DR Pfam; PF07496; zf-CW; 1.
DR PRINTS; PR00419; ADXRDTASE.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50934; SWIRM; 1.
DR PROSITE; PS51050; ZF_CW; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00454}.
FT DOMAIN 232..292
FT /note="CW-type"
FT /evidence="ECO:0000259|PROSITE:PS51050"
FT DOMAIN 374..472
FT /note="SWIRM"
FT /evidence="ECO:0000259|PROSITE:PS50934"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 964 AA; 107399 MW; AFB2B14903B902E7 CRC64;
MGRAERAPRL KRRRGPYPSL VPSAPPTPGH AVTGAEAAAA AAERRLGLAA RLLPSCARGA
RLRRGARSPG RRAPPRWRSE RCLFPETPGT SSAKRLFNVM ATPRGRTKKK ASFDHSPDSL
PLRSSGRQAK KKATETTDED EDGGSEKKYR KCEKAGCTAA CPVCFASASE RCAKNGYTSR
WYHLSCGEHF CNECFDHYYR SHKDGYDKYT TWKKIWTSNG KTEPSPKAFM ADQQLPYWVQ
CTKPECRKWR QLTKEIQLTP QIAKTYRCGM KPNTAIKPET SDHCSLPEDL RVLEVSNHWW
YSMLILPPLL KDSVAAPLLS AYYPDCVGMS PSCTSTNRAA ATGNASPGKL EHSKAAPSVH
VPGMNRYFQP FYQPNECGKA LCVRPDVMEL DELYEFPEYS RDPTMYLALR NLILALWYTN
CKEALTPQKC IPHIIVRGLV RIRCVQEVER ILYFMTRKGL INTGVLSVGA DQYLLPKDYH
NKSVIIIGAG PAGLAAARQL HNFGIKVTVL EAKDRIGGRV WDDKSFKGVT VGRGAQIVNG
CINNPVALMC EQLGISMHKF GERCDLIQEG GRITDPTIDK RMDFHFNALL DVVSEWRKDK
TQLQDVPLGE KIEEIYKAFI KESGIQFSEL EGQVLQFHLS NLEYACGSNL HQVSARSWDH
NEFFAQFAGD HTLLTPGYSV IIEKLAEGLD IRLKSPVQSV DYSGDEVQVT TTDGTGHSAQ
KVLVTVPLAL LQKGAIQFNP PLSEKKMKAI NSLGAGIIEK IALQFPYRFW DSKVQGADFF
GHVPPSASKR GLFAVFYDMD PQKKHSVLMS VIAGEAVASV RTLDDKQVLQ QCMATLRELF
KEQEVPDPTK YFVTRWSTDP WIQMAYSFVK TGGSGEAYDI IAEDIQGTIF FAGEVWILIP
NPSTCILISF SSQMISAQSS KTNSNTVKSL MTTDSRSLLT VLFLLPEAAV FNLPAIPSGL
HFIF
//
