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Database: UniProt
Entry: A0A099D1W3_9ACTN
LinkDB: A0A099D1W3_9ACTN
Original site: A0A099D1W3_9ACTN 
ID   A0A099D1W3_9ACTN        Unreviewed;       221 AA.
AC   A0A099D1W3;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=NADPH-dependent F420 reductase {ECO:0000313|EMBL:ASU80896.1};
DE   SubName: Full=Oxidoreductase {ECO:0000313|EMBL:KGI79812.1};
GN   Name=npdG {ECO:0000313|EMBL:ASU80896.1};
GN   ORFNames=CDG81_06685 {ECO:0000313|EMBL:ASU80896.1}, IL38_21715
GN   {ECO:0000313|EMBL:KGI79812.1};
OS   Actinopolyspora erythraea.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinopolysporales;
OC   Actinopolysporaceae; Actinopolyspora.
OX   NCBI_TaxID=414996 {ECO:0000313|EMBL:ASU80896.1, ECO:0000313|Proteomes:UP000215043};
RN   [1] {ECO:0000313|EMBL:KGI79812.1, ECO:0000313|Proteomes:UP000029737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIM90600 {ECO:0000313|EMBL:KGI79812.1,
RC   ECO:0000313|Proteomes:UP000029737};
RX   PubMed=25250723;
RA   Chen D., Feng J., Huang L., Zhang Q., Wu J., Zhu X., Duan Y., Xu Z.;
RT   "Identification and Characterization of a New Erythromycin Biosynthetic
RT   Gene Cluster in Actinopolyspora erythraea YIM90600, a Novel Erythronolide-
RT   Producing Halophilic Actinomycete Isolated from Salt Field.";
RL   PLoS ONE 9:E108129-E108129(2014).
RN   [2] {ECO:0000313|EMBL:ASU80896.1, ECO:0000313|Proteomes:UP000215043}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIM 90600 {ECO:0000313|EMBL:ASU80896.1,
RC   ECO:0000313|Proteomes:UP000215043};
RA   Yin M., Tang S.;
RT   "The complete genome sequence of moderately halophilic actinomycete
RT   Actinopolyspora erythraea YIM 90600, the producer of novel erythromycin,
RT   novel actinopolysporins A-C and tubercidin.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP022752; ASU80896.1; -; Genomic_DNA.
DR   EMBL; JPMV01000039; KGI79812.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A099D1W3; -.
DR   KEGG; aey:CDG81_06685; -.
DR   eggNOG; COG2085; Bacteria.
DR   HOGENOM; CLU_076368_1_0_11; -.
DR   OrthoDB; 5738121at2; -.
DR   Proteomes; UP000029737; Unassembled WGS sequence.
DR   Proteomes; UP000215043; Chromosome.
DR   GO; GO:0070967; F:coenzyme F420 binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR   GO; GO:0006740; P:NADPH regeneration; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR010185; NpdG.
DR   InterPro; IPR028939; P5C_Rdtase_cat_N.
DR   NCBIfam; TIGR01915; npdG; 1.
DR   PANTHER; PTHR14239; DUDULIN-RELATED; 1.
DR   PANTHER; PTHR14239:SF0; F420-DEPENDENT NADP REDUCTASE; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
FT   DOMAIN          8..104
FT                   /note="Pyrroline-5-carboxylate reductase catalytic N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03807"
SQ   SEQUENCE   221 AA;  23070 MW;  848C7CE4E7AE2ADE CRC64;
     MVDVRELTVG VLGGTGAQGK GLAIRWAQAG LRVLIGSRSA DRAADVAEEI ATTSGGSVLG
     RSNVDCAAEA DVVLAALPWE AHADTLRELR SELAGKIVVD CVNPLGFDAK GPYALPVEEG
     SAAQQAEALL PDSRVTAAFH HVSAVTLADT DVSHVDLDVL VLGDDREATD LVRSLADVIP
     GVRGIYGGRL RNAHQVEALT ANVIAINRRY KAHAGIRVTD V
//
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