ID A0A099DA61_9ACTN Unreviewed; 339 AA.
AC A0A099DA61;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=2-oxoisovalerate dehydrogenase {ECO:0000313|EMBL:KGI82796.1};
DE SubName: Full=Alpha-ketoacid dehydrogenase subunit beta {ECO:0000313|EMBL:ASU80533.1};
GN ORFNames=CDG81_22170 {ECO:0000313|EMBL:ASU80533.1}, IL38_02675
GN {ECO:0000313|EMBL:KGI82796.1};
OS Actinopolyspora erythraea.
OC Bacteria; Actinomycetota; Actinomycetes; Actinopolysporales;
OC Actinopolysporaceae; Actinopolyspora.
OX NCBI_TaxID=414996 {ECO:0000313|EMBL:ASU80533.1, ECO:0000313|Proteomes:UP000215043};
RN [1] {ECO:0000313|EMBL:KGI82796.1, ECO:0000313|Proteomes:UP000029737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM90600 {ECO:0000313|EMBL:KGI82796.1,
RC ECO:0000313|Proteomes:UP000029737};
RX PubMed=25250723;
RA Chen D., Feng J., Huang L., Zhang Q., Wu J., Zhu X., Duan Y., Xu Z.;
RT "Identification and Characterization of a New Erythromycin Biosynthetic
RT Gene Cluster in Actinopolyspora erythraea YIM90600, a Novel Erythronolide-
RT Producing Halophilic Actinomycete Isolated from Salt Field.";
RL PLoS ONE 9:E108129-E108129(2014).
RN [2] {ECO:0000313|EMBL:ASU80533.1, ECO:0000313|Proteomes:UP000215043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM 90600 {ECO:0000313|EMBL:ASU80533.1,
RC ECO:0000313|Proteomes:UP000215043};
RA Yin M., Tang S.;
RT "The complete genome sequence of moderately halophilic actinomycete
RT Actinopolyspora erythraea YIM 90600, the producer of novel erythromycin,
RT novel actinopolysporins A-C and tubercidin.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP022752; ASU80533.1; -; Genomic_DNA.
DR EMBL; JPMV01000009; KGI82796.1; -; Genomic_DNA.
DR RefSeq; WP_043569839.1; NZ_KN214174.1.
DR AlphaFoldDB; A0A099DA61; -.
DR KEGG; aey:CDG81_22170; -.
DR eggNOG; COG0022; Bacteria.
DR HOGENOM; CLU_012907_1_0_11; -.
DR OrthoDB; 3457658at2; -.
DR Proteomes; UP000029737; Unassembled WGS sequence.
DR Proteomes; UP000215043; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
FT DOMAIN 19..194
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 339 AA; 36802 MW; 37BDC06BB13DC22F CRC64;
MAAPTMESTG SSTTPTQTVT IAKGLNMALR NAMERDPKVL VMGEDVGKLG GVFRITDGLQ
KDFGEHRVLD TPLAESGIIG TAIGLAMRGF RPVCEIQFDG FIFPGFDQIV SQLSKMHYRS
QGKVKVPVVI RVPFGGGIGA VEHHSESPES LFAHVAGLKV VSCSNPVDAY WMLQQAIDCD
DPVLFFEPKR RYWEKGQLDP EAEHLPLVSS AVLRTGSDVT VATYGPMVKT CMDAATAAEE
DGNDIEVIDL RSLSPLDLGP VAESVRRTGR LVVVSESPPE SSVTSEVATR VQQECFYSLE
APVLRVNGFD TPYPPSKLEE GYLPDLDRVL DAVDRSLAY
//
