UniProt: A0A099JH55

Database: UniProt
Entry: A0A099JH55_9MICO

LinkDB:  A0A099JH55_9MICO 
Original site:  A0A099JH55_9MICO

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Ontology (1)   
   GO (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (12)   
   InterPro (7)   
   Pfam (2)   
   PROSITE (3)   
All databases (17)   

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ID   A0A099JH55_9MICO        Unreviewed;       394 AA.
AC   A0A099JH55;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Probable acetyl-CoA acetyltransferase {ECO:0000256|ARBA:ARBA00040529};
DE            EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
GN   ORFNames=BJ997_000785 {ECO:0000313|EMBL:MBB5640237.1}, GY21_08975
GN   {ECO:0000313|EMBL:KGJ76902.1};
OS   Cryobacterium roopkundense.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Cryobacterium.
OX   NCBI_TaxID=1001240 {ECO:0000313|EMBL:KGJ76902.1, ECO:0000313|Proteomes:UP000029864};
RN   [1] {ECO:0000313|EMBL:KGJ76902.1, ECO:0000313|Proteomes:UP000029864}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RuG17 {ECO:0000313|EMBL:KGJ76902.1,
RC   ECO:0000313|Proteomes:UP000029864};
RA   Sisinthy S.;
RL   Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:MBB5640237.1, ECO:0000313|Proteomes:UP000561726}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21065 {ECO:0000313|EMBL:MBB5640237.1,
RC   ECO:0000313|Proteomes:UP000561726};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGJ76902.1}.
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DR   EMBL; JPXF01000031; KGJ76902.1; -; Genomic_DNA.
DR   EMBL; JACHBQ010000001; MBB5640237.1; -; Genomic_DNA.
DR   RefSeq; WP_035836395.1; NZ_JPXF01000031.1.
DR   AlphaFoldDB; A0A099JH55; -.
DR   STRING; 1001240.GY21_08975; -.
DR   eggNOG; COG0183; Bacteria.
DR   OrthoDB; 1402717at2; -.
DR   Proteomes; UP000029864; Unassembled WGS sequence.
DR   Proteomes; UP000561726; Unassembled WGS sequence.
DR   GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00098; THIOLASE_1; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:KGJ76902.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029864};
KW   Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:KGJ76902.1}.
FT   DOMAIN          6..264
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          273..393
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        90
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        351
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        381
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   394 AA;  39901 MW;  48E5EC3B8D4AB0B5 CRC64;
     MTAPDVVILA GSRTPQGRVN GQLSSLTAVE LGAAAIAGAL ERAGVAPEQV DFVLMGQVLQ
     AGCGQNPARQ SSIAAGIPWN VPAMTLNKVC LSGLAAIIDA ARLIRLGEAD VVIAGGQESM
     SRAPHILAGS RQGWAYGTVS ALDHAAHDGL TDAFDGLSMG LSTELANEKL GLNRLEQDDV
     AAKSHQRTAA AVAAGIFEGE ITPLSVPQRK GDPLMLTTDE GVRAESTTDT LGKLRPAFSK
     DGNITAGNAA PLSDGASAIV VTSRAWAEEH GLSWLAVIEA SGQVAGPDNS LHSQPANAIA
     SALTKQGWTA ADLDVVEINE AFASVVVQSS KELGVSEDKV NIHGGGIAIG HPIGASGARV
     ALHAALELSR RAGGKAAVAL CGGGGQGEAL LLSR
//

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