ID   A0A099P614_PICKU        Unreviewed;       432 AA.
AC   A0A099P614;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=Vesicle-fusing ATPase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=JL09_g1483 {ECO:0000313|EMBL:KGK39426.1};
OS   Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Pichia.
OX   NCBI_TaxID=4909 {ECO:0000313|EMBL:KGK39426.1, ECO:0000313|Proteomes:UP000029867};
RN   [1] {ECO:0000313|Proteomes:UP000029867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SD108 {ECO:0000313|Proteomes:UP000029867};
RX   PubMed=25159171; DOI=10.1186/s12934-014-0121-4;
RA   Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT   "Exploiting Issatchenkia orientalis SD108 for succinic acid production.";
RL   Microb. Cell Fact. 13:121-121(2014).
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004481}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family.
CC       {ECO:0000256|ARBA:ARBA00006914, ECO:0000256|RuleBase:RU003651}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGK39426.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JQFK01000009; KGK39426.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A099P614; -.
DR   VEuPathDB; FungiDB:C5L36_0B09760; -.
DR   eggNOG; KOG0739; Eukaryota.
DR   HOGENOM; CLU_000688_21_2_1; -.
DR   Proteomes; UP000029867; Unassembled WGS sequence.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd02678; MIT_VPS4; 1.
DR   CDD; cd19521; RecA-like_VPS4; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041569; AAA_lid_3.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR007330; MIT_dom.
DR   InterPro; IPR036181; MIT_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR015415; Spast_Vps4_C.
DR   InterPro; IPR045253; VPS4_MIT.
DR   PANTHER; PTHR23074; AAA DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR23074:SF83; VESICLE-FUSING ATPASE; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17862; AAA_lid_3; 1.
DR   Pfam; PF04212; MIT; 1.
DR   Pfam; PF09336; Vps4_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00745; MIT; 1.
DR   SUPFAM; SSF116846; MIT domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003651};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU003651}.
FT   DOMAIN          4..81
FT                   /note="MIT"
FT                   /evidence="ECO:0000259|SMART:SM00745"
FT   DOMAIN          166..301
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          75..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        100..115
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   432 AA;  47982 MW;  2B2D07042BF46746 CRC64;
     MSSSADFLDK GVDLVKKAIE ADSNARYEEA YQLYYNGLDY LMLALKYEKN QKAKETIKAK
     FTEYLSRAEE LKEHVVNNNN KDQSSELSPT NGISKSKQLD PNSTKDKEDD NDSKKLRNQL
     ASSILSEKPN VKWSDIAGLE GAKDALKEAV ILPVKFPQLF TGKRKPVSGI LLYGPPGTGK
     SYLAKAVATE ANSTFFSVSS SDLVSKWMGE SERLVKQLFS MAREQKPSII FIDEVDALCG
     PRGEGESEAS RRIKTELLVQ MNGVGNDSQG VLVLGATNIP WQLDSAIRRR FERRIYIPLP
     DADARLEMFK LNIGDTPTTL TSADYHTLAN ITEGYSGHDI AVVVKDALMQ PIRKIQSATH
     FKQVGTQYQP CSPGEPGAIE MNWMELEGDQ LLEPDLCLND FLRAVKTNKP TVNQSDLSKF
     VEFTNDFGSE GN
//