ID A0A099S8X1_9CLOT Unreviewed; 888 AA.
AC A0A099S8X1;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=DP68_06795 {ECO:0000313|EMBL:KGK88561.1};
OS Clostridium sp. HMP27.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1487921 {ECO:0000313|EMBL:KGK88561.1, ECO:0000313|Proteomes:UP000030009};
RN [1] {ECO:0000313|EMBL:KGK88561.1, ECO:0000313|Proteomes:UP000030009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HMP27 {ECO:0000313|EMBL:KGK88561.1,
RC ECO:0000313|Proteomes:UP000030009};
RA Tan B.F., Foght J., Budwill K.;
RT "Draft genome sequence of Clostridium sp. HMP27 isolated from a coal
RT degrading methanogenic culture.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGK88561.1}.
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DR EMBL; JMFY01000014; KGK88561.1; -; Genomic_DNA.
DR RefSeq; WP_035307765.1; NZ_JMFY01000014.1.
DR AlphaFoldDB; A0A099S8X1; -.
DR STRING; 1487921.DP68_06795; -.
DR eggNOG; COG0249; Bacteria.
DR Proteomes; UP000030009; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000030009}.
FT DOMAIN 686..702
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 612..619
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 888 AA; 99815 MW; 229A7E8F99F0C0E1 CRC64;
MALTPMMQQY LEIKEKCKDC ILFFRLGDFY EMFFEDAEVA SKELELVLTG RDCGLDKRAP
MCGIPYHSAS SYISRLISKG YKVAIGEQLE DPSVAKGIVK RDITKIITPG TYTDSSFLEE
NKNNFIMSIH TDKDNAGLSF CDVSTGEFIS TYTKMEISVI LNEISKFNPS EILVNSNISE
SITLEIKERF KTSLTFIDDT YYNNENALKE QFLDFNPASF SKCVIKSSAA LLTYIIETQN
TSLSHIDKFE YYHILDFLSM DINSRKNLEL TETLREKSKK GSLLWVLDKT STSMGGRQLR
KWVEQPLVNK ELINNRLDAI EDIISNISLH EDIKESLKSI YDIERIVGKI SSKNVNAKEL
IALKNSIGNI PAIKQILSNF NSGLLKDMYL NIDGLSDIYN LLEESIVDNP SLSIKEGNII
KSGYNNDIDS LRDAKAHGKE WISKLEAQEK DFTGIKSLKV GYNKVFGYFI EITKSNIASI
PEGRYIRKQT LSNAERYITP ELKEMEEKIL GAEEKLTALE YDIFLQIRST IENEIDRMKK
SGHIISELDC LSSLATVALE NNYCKPSISD DNDLSITEGR HPVVEKMIPT GCFISNDTLM
DTKENQMILI TGPNMAGKST YMRQVALITI MAQIGSFVPA KSAKISICDK IFTRIGASDD
LAAGKSTFMV EMWEVANILQ NATNKSLVLL DEVGRGTSTF DGLSIAWSVI EHMCGDEDLK
CKTLFATHYH ELIVLENKLK GVKNFSVSIK KIDNELVFLR KIVQGGADES YGIEVAKLAG
LPDKVIERAK EILNTIEKNK NVVTNIDELS CNTSEVAISK TLSEPKTNAI PSKNHEIKEE
SLQLNFTDIE KSNLLDEIAS IDIMNVTPIE GFNKLYEIIR KAKTISKV
//
