ID A0A099ZT54_TINGU Unreviewed; 766 AA.
AC A0A099ZT54;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 03-MAY-2023, entry version 42.
DE SubName: Full=Rho guanine nucleotide exchange factor 6 {ECO:0000313|EMBL:KGL85454.1};
GN ORFNames=N309_10825 {ECO:0000313|EMBL:KGL85454.1};
OS Tinamus guttatus (White-throated tinamou).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Tinamiformes; Tinamidae; Tinamus.
OX NCBI_TaxID=94827 {ECO:0000313|EMBL:KGL85454.1, ECO:0000313|Proteomes:UP000053641};
RN [1] {ECO:0000313|EMBL:KGL85454.1, ECO:0000313|Proteomes:UP000053641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N309 {ECO:0000313|EMBL:KGL85454.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR EMBL; KL898365; KGL85454.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099ZT54; -.
DR STRING; 94827.A0A099ZT54; -.
DR Proteomes; UP000053641; Unassembled WGS sequence.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd21265; CH_alphaPIX; 1.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12060; SH3_alphaPIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035788; AlphaPIX_SH3.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000053641};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..110
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 161..220
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 242..422
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 444..549
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 110..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 381..443
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 708..756
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 766 AA; 86242 MW; DFA82D49F96EE7A9 CRC64;
MNPEEQTVTW LISLGVLNSP KKVVEDPEEF LKTSLKDGTV LCKLINRLLP GSAEKYCLEP
KNEAECISNI EEFLKGCALL KVELFDPHDL YTGEQFSKVL STLTAINKAT EDQPSKRPCS
QLSSHSSTAE DPHATSNGTA SRAARVLRRQ SKAVEMTENG SHQLVVKARF NFKQTNEDEL
SVNKGDIIYV TRVEEGGWWE GTLNGKTGWF PSNYVREIKS SDKPLSPKAL KGLESTQLTK
NYYPVVLQNI LETERDYAKE LQSLLGTYLR PLQSYDKLSA VDIAALLGNV EEISAFQQTL
NQALEEVAKL PENQQRVGGC FMNLMPQFRS LYLTYCANHP SAVSVLTQHS DELEKFMESQ
GAANPGILLL TSSLSKPFVR LDKYVTLLQE LERHMEEAHA DHEEVLKAVT SFKSLVSQCQ
ELRKRKQLEL QILSESIQRW EGEDIKTMGS IIYMSQVMVQ CGGSEEKEER YFLLFANVLL
MLSASPRMSG FIYQGRLPLT GMTLTKLDDA EGNEHTFEIA GNMMERITVS CSSSQDLHEW
LDHLQRLTKG TCNITSKTQS WSAHSTFSST GQIRGPLEPP KILKPWSLSC LRPAPPLRPS
AALSYKEDSS KSPKTMKKFL PKRKTERKAS DEEFVIRKST AALEEDAQIL KVIEAYCTGA
GFQQALSSGS RKDSIPQVLL PEEEKIIIEE TRSNGQTVTE EKSLVDTVYA LKDEVKELKQ
ENKRMKQCLE EELKSRKDLE KLVRRLLKQT DECAREDTGR KSSLIA
//
