ID A0A0A0A0K1_CHAVO Unreviewed; 1026 AA.
AC A0A0A0A0K1;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KGL88114.1};
DE Flags: Fragment;
GN ORFNames=N301_11688 {ECO:0000313|EMBL:KGL88114.1};
OS Charadrius vociferus (Killdeer) (Aegialitis vocifera).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; Charadrius.
OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL88114.1, ECO:0000313|Proteomes:UP000053858};
RN [1] {ECO:0000313|EMBL:KGL88114.1, ECO:0000313|Proteomes:UP000053858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL88114.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KL870365; KGL88114.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A0A0K1; -.
DR STRING; 50402.A0A0A0A0K1; -.
DR Proteomes; UP000053858; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0002218; P:activation of innate immune response; IEA:UniProt.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410:SF2; TOLL-LIKE RECEPTOR 7; 1.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00365; LRR_SD22; 9.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KGL88114.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053858};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 866..1010
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KGL88114.1"
FT NON_TER 1026
FT /evidence="ECO:0000313|EMBL:KGL88114.1"
SQ SEQUENCE 1026 AA; 118118 MW; 81C365FB485EF828 CRC64;
LLSGAWFPKT LPCDVTSSEG TVTVDCTDRR LTEVPRGIPA NATNLTLSIN HIPHIYPTTF
AHLENLVEID LRCNCVPVRL GPKDRVCTRR PKIENGTFGA LTRLKSLYLD ANQLLEIPGG
LPPTLRLLSL EANSIFSIQK ANFSELANIE VLYLGQNCYY RNPCNVSYEI EKTAFLELKK
LTILSLKANN LTHIPPNLSS TLKELYIYNN MIQVIQEHDL SALHNLEILD LSGNCPRCYN
APYPCIPCPK RTIEIHSKAF YSLENLRILR LHSNSLESVP SSWFKNIKNL QVLDLSQNFL
IKEIGEAQFL KFIPSLVELD LSFNFELKMY SPFLNLSKTF SSLSNLETLR LRGYVFKELR
EANLAPLLSL RNLTVLDLET NFIKIADLKV FKEFPALKLI DLSVNKISPS SGESNFYGFC
SNPSISAEQY NRQVLQEMQY FRYDVYERNC RSKDKEAASY QSSVKEECLK YGETLDLSRN
NIFFINPSDF QGLSSLRCLN LSGNAISQTL NGSEFYHLSA LKYLDFSNNR IDLLYSTAFK
ELELLEILDL SNNKYYFLAE GVTHTLSFMK NLAHLKKLMM NENEISTSIN TGIESQSLQI
LEFRGNRLDV LWMDGNARYL SFFRNLTSLE QLDISFNSLT FLPHGVFQAL PPELKILNLT
NNRMKSFNWG NLQYLEKLVT LDLSNNLLGT VPQELSNCSS TLQELMLRNN RIQRLTKHFL
RGAFQLKYLD LSANQIQTIK KSSFPENVIN NLRMLLLHGN PFKCNCDAVW FVWWINQTQV
TIPLLATDVT CAGPGAHKGR SVVFLDLYTC ELDTSYLILY ALSASTVLGF MVFTMMSHLY
FWDVWYSYHY CAAKLKGYRR LSFPDACYDA FIAYDNRDPA VNEWVLKELV ERLEDEKARQ
FNLCLEERDW LPGQPVFDNL SQSIQLSKKT IFVLTNRYIK SGRFKTAFYM AHQRLLDEKM
DVIILIFLEK VLQKSRYVRL RKRLCRSSVL EWPTNPRSQP YFWQCLKNAI ATSNTLAYNK
LLQETV
//
