ID A0A0A0L2L5_CUCSA Unreviewed; 530 AA.
AC A0A0A0L2L5;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Nucleobase-ascorbate transporter 10 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Csa_4G643090 {ECO:0000313|EMBL:KGN55279.1};
OS Cucumis sativus (Cucumber).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3659 {ECO:0000313|EMBL:KGN55279.1, ECO:0000313|Proteomes:UP000029981};
RN [1] {ECO:0000313|EMBL:KGN55279.1, ECO:0000313|Proteomes:UP000029981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 9930 {ECO:0000313|Proteomes:UP000029981};
RX PubMed=19881527; DOI=10.1038/ng.475;
RA Huang S., Li R., Zhang Z., Li L., Gu X., Fan W., Lucas W.J., Wang X.,
RA Xie B., Ni P., Ren Y., Zhu H., Li J., Lin K., Jin W., Fei Z., Li G.,
RA Staub J., Kilian A., van der Vossen E.A., Wu Y., Guo J., He J., Jia Z.,
RA Ren Y., Tian G., Lu Y., Ruan J., Qian W., Wang M., Huang Q., Li B.,
RA Xuan Z., Cao J., Asan null, Wu Z., Zhang J., Cai Q., Bai Y., Zhao B.,
RA Han Y., Li Y., Li X., Wang S., Shi Q., Liu S., Cho W.K., Kim J.Y., Xu Y.,
RA Heller-Uszynska K., Miao H., Cheng Z., Zhang S., Wu J., Yang Y., Kang H.,
RA Li M., Liang H., Ren X., Shi Z., Wen M., Jian M., Yang H., Zhang G.,
RA Yang Z., Chen R., Liu S., Li J., Ma L., Liu H., Zhou Y., Zhao J., Fang X.,
RA Li G., Fang L., Li Y., Liu D., Zheng H., Zhang Y., Qin N., Li Z., Yang G.,
RA Yang S., Bolund L., Kristiansen K., Zheng H., Li S., Zhang X., Yang H.,
RA Wang J., Sun R., Zhang B., Jiang S., Wang J., Du Y., Li S.;
RT "The genome of the cucumber, Cucumis sativus L.";
RL Nat. Genet. 41:1275-1281(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; CM002925; KGN55279.1; -; Genomic_DNA.
DR RefSeq; XP_004141407.2; XM_004141359.2.
DR AlphaFoldDB; A0A0A0L2L5; -.
DR STRING; 3659.A0A0A0L2L5; -.
DR EnsemblPlants; KGN55279; KGN55279; Csa_4G643090.
DR GeneID; 101210431; -.
DR Gramene; KGN55279; KGN55279; Csa_4G643090.
DR KEGG; csv:101210431; -.
DR eggNOG; KOG1292; Eukaryota.
DR OMA; WEKFSLY; -.
DR OrthoDB; 345287at2759; -.
DR Proteomes; UP000029981; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR NCBIfam; NF037981; NCS2_1; 1.
DR PANTHER; PTHR11119:SF94; NUCLEOBASE-ASCORBATE TRANSPORTER 10-RELATED; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029981};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 530 AA; 58719 MW; C71ADBD5D31082CE CRC64;
MTNKPTEDPL QPHPVKEQLP GIQYCINSPP PWPEAFVLGF QHYVLTLGFS VLIPSLIVPQ
MGGGNVEKAK VIQTLLFVSG LNTLFQSLFG TRLPVVVVGS YAYLIPTISI VLAKRYTSLT
DPQDRFIQTM QGIQGALIVA SCFRMVMGFL GFWRNTVRFF SPLSVVPCVT FTGLGLYHFG
FPMLARCVEI GLPGLIIIVF ISQYLPHLLK TKKPIYDRYS VLFSIVIIWL YAQLLTSSTV
YNHKPTTTQK SCRTDQAGLL STAPWIYIPY PFQWGGPTFN AGEAFAMMAA SVVSLFESTG
TFFAASRYGS ATPVPASIIG RGSGWLGVGV LLNGMFGSLT GSCASVENAG LLALTRVGSR
RVIQISAGFM IFFSVFGKFG ALFASIPLPI IAALYCVFFG YVSSSGLGFL QFCNLNSFRT
KFILGTSFFL GLSIPQYFRE YYRRDLNLSE HIYSGHGWFN DVVVVIFMSH ATIASLVALI
LDCTLFREND ATRKDSGLHW WEKFCLYSSD VRNDEFYALP FCLNKLFPSV
//
