ID A0A0A0LF74_CUCSA Unreviewed; 986 AA.
AC A0A0A0LF74;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=HP domain-containing protein {ECO:0000259|PROSITE:PS51089};
GN ORFNames=Csa_3G812240 {ECO:0000313|EMBL:KGN59352.1};
OS Cucumis sativus (Cucumber).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3659 {ECO:0000313|EMBL:KGN59352.1, ECO:0000313|Proteomes:UP000029981};
RN [1] {ECO:0000313|EMBL:KGN59352.1, ECO:0000313|Proteomes:UP000029981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 9930 {ECO:0000313|Proteomes:UP000029981};
RX PubMed=19881527; DOI=10.1038/ng.475;
RA Huang S., Li R., Zhang Z., Li L., Gu X., Fan W., Lucas W.J., Wang X.,
RA Xie B., Ni P., Ren Y., Zhu H., Li J., Lin K., Jin W., Fei Z., Li G.,
RA Staub J., Kilian A., van der Vossen E.A., Wu Y., Guo J., He J., Jia Z.,
RA Ren Y., Tian G., Lu Y., Ruan J., Qian W., Wang M., Huang Q., Li B.,
RA Xuan Z., Cao J., Asan null, Wu Z., Zhang J., Cai Q., Bai Y., Zhao B.,
RA Han Y., Li Y., Li X., Wang S., Shi Q., Liu S., Cho W.K., Kim J.Y., Xu Y.,
RA Heller-Uszynska K., Miao H., Cheng Z., Zhang S., Wu J., Yang Y., Kang H.,
RA Li M., Liang H., Ren X., Shi Z., Wen M., Jian M., Yang H., Zhang G.,
RA Yang Z., Chen R., Liu S., Li J., Ma L., Liu H., Zhou Y., Zhao J., Fang X.,
RA Li G., Fang L., Li Y., Liu D., Zheng H., Zhang Y., Qin N., Li Z., Yang G.,
RA Yang S., Bolund L., Kristiansen K., Zheng H., Li S., Zhang X., Yang H.,
RA Wang J., Sun R., Zhang B., Jiang S., Wang J., Du Y., Li S.;
RT "The genome of the cucumber, Cucumis sativus L.";
RL Nat. Genet. 41:1275-1281(2009).
CC -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC {ECO:0000256|ARBA:ARBA00008418}.
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DR EMBL; CM002924; KGN59352.1; -; Genomic_DNA.
DR RefSeq; XP_004136595.1; XM_004136547.2.
DR RefSeq; XP_011652131.1; XM_011653829.1.
DR AlphaFoldDB; A0A0A0LF74; -.
DR STRING; 3659.A0A0A0LF74; -.
DR EnsemblPlants; KGN59352; KGN59352; Csa_3G812240.
DR GeneID; 101208134; -.
DR Gramene; KGN59352; KGN59352; Csa_3G812240.
DR KEGG; csv:101208134; -.
DR eggNOG; KOG0443; Eukaryota.
DR OMA; DPNIWSA; -.
DR OrthoDB; 25995at2759; -.
DR Proteomes; UP000029981; Chromosome 3.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR GO; GO:0007015; P:actin filament organization; IEA:UniProt.
DR GO; GO:0051014; P:actin filament severing; IBA:GO_Central.
DR CDD; cd11290; gelsolin_S1_like; 1.
DR CDD; cd11289; gelsolin_S2_like; 1.
DR CDD; cd11292; gelsolin_S3_like; 1.
DR CDD; cd11293; gelsolin_S4_like; 1.
DR CDD; cd11288; gelsolin_S5_like; 1.
DR CDD; cd11291; gelsolin_S6_like; 1.
DR Gene3D; 3.40.20.10; Severin; 6.
DR Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR007122; Villin/Gelsolin.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR PANTHER; PTHR11977:SF85; HP DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11977; VILLIN; 1.
DR Pfam; PF00626; Gelsolin; 6.
DR Pfam; PF02209; VHP; 1.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 6.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 6.
DR SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR PROSITE; PS51089; HP; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Reference proteome {ECO:0000313|Proteomes:UP000029981};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 921..986
FT /note="HP"
FT /evidence="ECO:0000259|PROSITE:PS51089"
FT REGION 772..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 809..825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..911
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 986 AA; 108446 MW; 17109282D713E183 CRC64;
MSSSAKVLDP AFQAVGQRVG TEIWRIENFQ PVPLSKSDYG KFYMGDSYIV LQTTQGKGGS
FLYDIHFWIG RDTSQDEAGT AAIKTVELDA SLGGRAVQYR EIQGHESEKF LSYFKPCIIP
LEGGVASGFK KPEEEQFETR LYVCRGKRVV RMKQVPFARS SLNHDDVFIL DTESKIFQFN
GANSNIQERA KALEVVQFLK DKNHEGKCDV AIVDDGKLDT ESDSGEFWVL FGGFAPIGKK
VASEDDIIPE SAPAKLYSID GGEVKVVDGE LSKSLLENNK CYLLDCGAEI FVWVGRVTQV
EERKAAIQEA EEFIASQNRP KATRVTRVIQ GYETHSFKSN FESWPVGSVT TGAEEGRGKV
AALLKQQGLG LKGLAKSAPT NEEVPPLLEG GGKMEVWRIN GSAKTPLLAE DIGKFYSGDC
YIILYTYHSG ERKEDYFLCS WFGKDSIEED QKMATRLTNT MSNSLKGRPV QGRIFEGKEP
PQFIALFQPF VVLKGGLSSG YKKVIADKAL ADETYTEDSV ALIRISQTSI HNNKAVQVEA
VATSLNSAEC FVLQSGSSVF TWHGNQSTFE QQQLAAKVAE FLKPGVTLKH AKEGTESSTF
WFALGGKQSY NGKKVPQDTV RDPHLYAFSF NRGKFQVEEI YNFSQDDLLT EDILILDTQA
EVFIWIGQSV DPKEKQNAWE IGQKYVEMAA SLEGLSPHVP LYKVSEGNEP CFFTTYFSWD
YTKAVVQGNS FQKKVTLLFG IGHIVEEKSN GNQGGGPTQR ASALAALSSA FNPSADKSTH
LSPDKSNGSS QGSGPRQRAE ALAALTSAFK SSPPKTSTAS RVSGRGKGSQ RAAAVAALSS
VLTAEKKKGN DSSPPSNSSP PPESNAPGAA EEKNDVSQQI ESSPEEVLDL KELGETSPIL
KNNHDDADVN QDSLQEENGD DNNLSVFSYD RLKAKSDNPV TGIDFKKREA YLSDEEFQTV
FGTTKEAFYK LPKWKQDMHK KKADLF
//
