ID A0A0A1DGH2_NOCSI Unreviewed; 509 AA.
AC A0A0A1DGH2;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Cell division protein FtsI [Peptidoglycan synthetase] {ECO:0000313|EMBL:AIY15603.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:AIY15603.1};
DE SubName: Full=Penicillin-binding protein {ECO:0000313|EMBL:GEB15169.1};
GN ORFNames=KR76_00255 {ECO:0000313|EMBL:AIY15603.1}, NSI01_34840
GN {ECO:0000313|EMBL:GEB15169.1};
OS Nocardioides simplex (Arthrobacter simplex).
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Pimelobacter.
OX NCBI_TaxID=2045 {ECO:0000313|EMBL:AIY15603.1, ECO:0000313|Proteomes:UP000030300};
RN [1] {ECO:0000313|EMBL:AIY15603.1, ECO:0000313|Proteomes:UP000030300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-2033D {ECO:0000313|EMBL:AIY15603.1,
RC ECO:0000313|Proteomes:UP000030300};
RX PubMed=25573942;
RA Shtratnikova V.Y., Schelkunov M.I., Pekov Y.A., Fokina V.V.,
RA Logacheva M.D., Sokolov S.L., Bragin E.Y., Ashapkin V.V., Donova M.V.;
RT "Complete Genome Sequence of Steroid-Transforming Nocardioides simplex VKM
RT Ac-2033D.";
RL Genome Announc. 3:0-0(2015).
RN [2] {ECO:0000313|EMBL:GEB15169.1, ECO:0000313|Proteomes:UP000318936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 12069 {ECO:0000313|EMBL:GEB15169.1,
RC ECO:0000313|Proteomes:UP000318936};
RA Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT "Whole genome shotgun sequence of Pimelobacter simplex NBRC 12069.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP009896; AIY15603.1; -; Genomic_DNA.
DR EMBL; BJMC01000016; GEB15169.1; -; Genomic_DNA.
DR RefSeq; WP_038675799.1; NZ_JAAARG010000162.1.
DR AlphaFoldDB; A0A0A1DGH2; -.
DR STRING; 2045.KR76_00255; -.
DR KEGG; psim:KR76_00255; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_0_11; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000030300; Chromosome.
DR Proteomes; UP000318936; Unassembled WGS sequence.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:AIY15603.1};
KW Cell division {ECO:0000313|EMBL:AIY15603.1};
KW Glycosyltransferase {ECO:0000313|EMBL:AIY15603.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030300};
KW Transferase {ECO:0000313|EMBL:AIY15603.1}.
FT DOMAIN 161..504
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 239..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 509 AA; 54315 MW; 6A69F5FCB21D01CE CRC64;
MNKPIRTVSI FCMFLFLALM ANVTYVQFWK AEDYNTDPRN ARVAEASFSR ERGQILVGDE
PVATSKPSDD QYKYLRVYPS SGARMFAPVT GYLQLGSQTG IERSQNAVLT GEDPQLFVTR
LVDLLKGDQT QGGNVVLTLN AAAQKAAFEG LRDTLGPRGE GSVVAIQPKT GRVLAMASYP
SYDPNELATH DSKSAAAAYE QLDKDPRDPL VNRAIQTRLF PGSTFKLVTA AAAIESGKYH
GDDQVPAGSS YQPPGTTRTI GNDGRSQCNP SKISFATALD WSCNTTFAHL AVEVGPEKMR
DQAEKFGFNS NYLLDLKGQA QSVYPTGIPL SDKDGGGTRE LSDAETAQTG IGQFEVQSTP
LQMAMVTAAI ANQGTLMRPY LVEQVQTAGF DVLRTTEPDK LSDAVSPQTA RELTDLLVSV
VDNGTASPAA ISGVKVAGKT GTAQRTSTRC SAGGKPPYAW FVSYAPADNA EVAVAVMIEE
APDRACDEIA GGQLGGPIAK AVMEAVLKK
//
