ID A0A0A1DK83_NOCSI Unreviewed; 788 AA.
AC A0A0A1DK83;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Cysteine protease {ECO:0000313|EMBL:AIY17007.1, ECO:0000313|EMBL:GEB12932.1};
GN ORFNames=KR76_10000 {ECO:0000313|EMBL:AIY17007.1}, NSI01_12470
GN {ECO:0000313|EMBL:GEB12932.1};
OS Nocardioides simplex (Arthrobacter simplex).
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Pimelobacter.
OX NCBI_TaxID=2045 {ECO:0000313|EMBL:AIY17007.1, ECO:0000313|Proteomes:UP000030300};
RN [1] {ECO:0000313|EMBL:AIY17007.1, ECO:0000313|Proteomes:UP000030300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-2033D {ECO:0000313|EMBL:AIY17007.1,
RC ECO:0000313|Proteomes:UP000030300};
RX PubMed=25573942;
RA Shtratnikova V.Y., Schelkunov M.I., Pekov Y.A., Fokina V.V.,
RA Logacheva M.D., Sokolov S.L., Bragin E.Y., Ashapkin V.V., Donova M.V.;
RT "Complete Genome Sequence of Steroid-Transforming Nocardioides simplex VKM
RT Ac-2033D.";
RL Genome Announc. 3:0-0(2015).
RN [2] {ECO:0000313|EMBL:GEB12932.1, ECO:0000313|Proteomes:UP000318936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 12069 {ECO:0000313|EMBL:GEB12932.1,
RC ECO:0000313|Proteomes:UP000318936};
RA Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT "Whole genome shotgun sequence of Pimelobacter simplex NBRC 12069.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP009896; AIY17007.1; -; Genomic_DNA.
DR EMBL; BJMC01000008; GEB12932.1; -; Genomic_DNA.
DR RefSeq; WP_038678003.1; NZ_JAAARG010000300.1.
DR AlphaFoldDB; A0A0A1DK83; -.
DR STRING; 2045.KR76_10000; -.
DR KEGG; psim:KR76_10000; -.
DR eggNOG; COG1305; Bacteria.
DR HOGENOM; CLU_012121_2_0_11; -.
DR OrthoDB; 3651060at2; -.
DR Proteomes; UP000030300; Chromosome.
DR Proteomes; UP000318936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.10.620.30; -; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR021878; TgpA_N.
DR InterPro; IPR002931; Transglutaminase-like.
DR PANTHER; PTHR42736; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR42736:SF1; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR Pfam; PF11992; TgpA_N; 1.
DR Pfam; PF01841; Transglut_core; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:AIY17007.1};
KW Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:AIY17007.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030300};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 82..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 497..563
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT REGION 554..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..578
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 84513 MW; B84E8DEFCB8836FC CRC64;
MSALSGSQPV VVVPQRGRRA GAALPWWLAV VDAVLVVGLG VLCAWPLGAA YTGSRWLLAV
VTGLLVGVLV GWLGARWRWG PWTTTLAAAV GYFAVGSAVA VPNRAQGGGV VPTADSLRDL
TVGLVHAWRE ALTLPVPLGE SGVVLIVPLV IGLVGGLVAT VLLWRSRSPG LAGVVLGLVL
VLASAFGDIA AGAALTRGLA VAAVGLVWLQ WRGQRHVRGR WGRRVLATLL VVGVAGGAAA
GLGSLSDPAA HREVLRDHVD PPFDPRDYPS PLAKFRAYKK EPVRTESILF TVDNLEPGTL
VRLAVMDTYD GIVWNVSGGP GSAHDSGTFR RLRNDPEANA RATVRGRVTI GSYTGVWVPS
IGETLSMTPV RDGRTDDTAA AELVINPETG TVAQIGGVAP GTSFEVEAVA PPSLVEEEIA
VLEADESVSL PPPAIVPEEL VDRVQRWESE DRFGGGTGGE LAQFLRDAFR EHGFYSDGID
DDVPAGHGAS RLAMLTKTAN PVGNAEQYAA AMGVIGQRLG LPIRVVVGFK VPPGTGDVRG
ENMTAWTEVK LGDAGWVPFE PTPPEDQKLR RPNDDPDEEP QPQVLQPPRV PGEPKEASDN
LQQGDGQRKD LDILEVLGAI IGIVLDVAKV LLILSPLWGV LLFKLLRRRR RRKACDATVR
LTGAWRELAD RMRDLGVRPA PGATRRESAY AAADRYDVVP VVTLAHTADR HVYGEGEPSI
EEAQAYWADV DTALKRLRKE TPWWRRLLAR FSLASVPWRS GLDRVRGAAA RRGQALRRRA
GTLRRKRR
//
