ID A0A0A1DKF8_NOCSI Unreviewed; 457 AA.
AC A0A0A1DKF8;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Peptidase, M16 family {ECO:0000313|EMBL:AIY17117.1};
DE SubName: Full=Putative zinc protease {ECO:0000313|EMBL:GEB13098.1};
GN ORFNames=KR76_10810 {ECO:0000313|EMBL:AIY17117.1}, NSI01_14130
GN {ECO:0000313|EMBL:GEB13098.1};
OS Nocardioides simplex (Arthrobacter simplex).
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Pimelobacter.
OX NCBI_TaxID=2045 {ECO:0000313|EMBL:AIY17117.1, ECO:0000313|Proteomes:UP000030300};
RN [1] {ECO:0000313|EMBL:AIY17117.1, ECO:0000313|Proteomes:UP000030300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-2033D {ECO:0000313|EMBL:AIY17117.1,
RC ECO:0000313|Proteomes:UP000030300};
RX PubMed=25573942;
RA Shtratnikova V.Y., Schelkunov M.I., Pekov Y.A., Fokina V.V.,
RA Logacheva M.D., Sokolov S.L., Bragin E.Y., Ashapkin V.V., Donova M.V.;
RT "Complete Genome Sequence of Steroid-Transforming Nocardioides simplex VKM
RT Ac-2033D.";
RL Genome Announc. 3:0-0(2015).
RN [2] {ECO:0000313|EMBL:GEB13098.1, ECO:0000313|Proteomes:UP000318936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 12069 {ECO:0000313|EMBL:GEB13098.1,
RC ECO:0000313|Proteomes:UP000318936};
RA Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT "Whole genome shotgun sequence of Pimelobacter simplex NBRC 12069.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; CP009896; AIY17117.1; -; Genomic_DNA.
DR EMBL; BJMC01000008; GEB13098.1; -; Genomic_DNA.
DR RefSeq; WP_038678205.1; NZ_JAAARG010000254.1.
DR AlphaFoldDB; A0A0A1DKF8; -.
DR STRING; 2045.KR76_10810; -.
DR KEGG; psim:KR76_10810; -.
DR eggNOG; COG0612; Bacteria.
DR HOGENOM; CLU_009902_3_3_11; -.
DR OrthoDB; 9811314at2; -.
DR Proteomes; UP000030300; Chromosome.
DR Proteomes; UP000318936; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR11851:SF149; GH01077P; 1.
DR PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:GEB13098.1};
KW Protease {ECO:0000313|EMBL:GEB13098.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030300}.
FT DOMAIN 52..200
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 207..389
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 457 AA; 48631 MW; 38E6B53DFD67CA08 CRC64;
MSTTRTTTAG QRSAGRPSAV PRASTRTLET VRDETGQVTS LVRRTQLASG LRIVTEQMAG
ARSASVGVWV GVGSRDETAK THGASHFLEH LLFKGTTERS ALDISIELDA VGGEFNAFTA
KEYTCFHARV LSDDLPLAVD VLGDMITGSV IATPDVDAER DVILDEIAMH DDDPDDVVQN
LLAALAWGED SALGRPIAGT DASIEAMTPA QIKRFYRRHY VPANTVISVA GAVDHAAVVR
AVKKAFARHD WLDTVAAPVA PRAAAARRRP RIATAQGHVT RPFEQVNLVL GCEGLTRDDE
RRYALGVLNT ALGGGTSSRL FQEVREHRGL AYSVYSFAAH YADSGLVGVA VGCLPDRTDD
VLAVVREQLA IIAAEGITAD ELARGKGQLV GGMILGLEDS GSRMMRLGKN ELVNGEVLGI
DEVIARIEGV TLEQVREVAA EVFGRPELLA QVGPGGA
//
