ID A0A0A1TFK7_9HYPO Unreviewed; 733 AA.
AC A0A0A1TFK7;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 13-SEP-2023, entry version 33.
DE RecName: Full=Peptidase M3A/M3B catalytic domain-containing protein {ECO:0000259|Pfam:PF01432};
GN ORFNames=VHEMI09144 {ECO:0000313|EMBL:CEJ93564.1};
OS [Torrubiella] hemipterigena.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC Clavicipitaceae incertae sedis; 'Torrubiella' clade.
OX NCBI_TaxID=1531966 {ECO:0000313|EMBL:CEJ93564.1, ECO:0000313|Proteomes:UP000039046};
RN [1] {ECO:0000313|EMBL:CEJ93564.1, ECO:0000313|Proteomes:UP000039046}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Horn F., Habel A., Scharf D.H., Dworschak J., Brakhage A.A., Guthke R.,
RA Hertweck C., Linde J.;
RT "Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus
RT Verticillium hemipterigenum.";
RL Genome Announc. 3:e01439-e01414(2015).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
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DR EMBL; CDHN01000005; CEJ93564.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A1TFK7; -.
DR HOGENOM; CLU_001805_1_2_1; -.
DR OrthoDB; 735202at2759; -.
DR Proteomes; UP000039046; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06455; M3A_TOP; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR024077; Neurolysin/TOP_dom2.
DR InterPro; IPR024080; Neurolysin/TOP_N.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR PANTHER; PTHR11804:SF84; SACCHAROLYSIN; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000039046};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT DOMAIN 239..726
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 733 AA; 83566 MW; 742124FB1B26D6F5 CRC64;
MATYTNSANC GRRCPQPLPR ILSTEEIVPT MERIISQYEA ARNSVLNNVT VETASFASVL
QPIVDVEQET NGEIGVIWML QYGAPEIATQ EAVHKARQLF VAAEGCWNSD DSMYKLLVAA
RDNSDKDANP DVASKLLLDH TLLRYKLAGC GAKANRNNET QESFSKESLD LSNALSTTLS
NIAQENDGMW FAVEELEDLP SDELSRIKQK RQLEIVPHEQ GKEMIFVPFS NGGTIAVLTF
SGNQQVRKRM YLADQRKLQK NIPILQDIVV KRQRLAKRLG YESHAHMRME DRLLAGPEQV
HELLESLTDG LIRRGREELD VIQRARLKDM RQRQNVSSNG HSVAKSAFPP WDLKYYQNIV
NIDRNIDQSK IAEYFSMEYA IPAMLQIFNT TLGLQFDPIP DDQMQRNEKW DDSVTAFAVW
DTRSSSDEAT FVGYLYFDVL WRPNKFRGAH NVTMEYGFER SNGDRKYPST IVMSAFPTAS
GDSRLVLLKH HQLLTVFHEL GHAIHSLVSR TKYSRFHGTS LPPDFVEIPS LMLENWCWMP
EVLKSMSTHY SYLCPEYLAK WKAENPGKEQ PPKEIPDAIV DALVKYRYAS RGLYHLYQLS
ISLFDMAIHS PSSAVEATAV NVQKLWYDIR ERIEGLDFTE VRDIGSELVA FNHLLGGFDV
AYYSYLCCSS FAQDLFQNLF VEEPMNPEAW DRYRRIILQP GGEHLALYKL VEEALGHSPD
LTALIKPLRN AVL
//
