ID   A0A0A1U301_ENTIV        Unreviewed;       591 AA.
AC   A0A0A1U301;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|Pfam:PF00617};
GN   ORFNames=EIN_229740 {ECO:0000313|EMBL:ELP88441.1};
OS   Entamoeba invadens IP1.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP88441.1, ECO:0000313|Proteomes:UP000014680};
RN   [1] {ECO:0000313|EMBL:ELP88441.1, ECO:0000313|Proteomes:UP000014680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP1 {ECO:0000313|EMBL:ELP88441.1,
RC   ECO:0000313|Proteomes:UP000014680};
RA   Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB206756; ELP88441.1; -; Genomic_DNA.
DR   RefSeq; XP_004255212.1; XM_004255164.1.
DR   AlphaFoldDB; A0A0A1U301; -.
DR   EnsemblProtists; ELP88441; ELP88441; EIN_229740.
DR   GeneID; 14887287; -.
DR   KEGG; eiv:EIN_229740; -.
DR   VEuPathDB; AmoebaDB:EIN_229740; -.
DR   OrthoDB; 23309at2759; -.
DR   Proteomes; UP000014680; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   Pfam; PF00617; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014680}.
FT   DOMAIN          398..538
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|Pfam:PF00617"
FT   REGION          39..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..376
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   591 AA;  68823 MW;  84A286CE6F63411D CRC64;
     MSKNRRTRAS FGYSVPPPIQ INTTAITPRE YTIAIRQFSN SSTQQESREK NSHSPTSGFE
     KTFIKLRGFI GGKEKEQKEM ETTLELILTS IKTLNPPHQL IDIFRFHNFI LLPQFNDIQF
     IDPRIYVWRT EKRRRYILGE LCYRALSKIF TTSEMIEMIF GKDNMTNPIC TTFLDTVVTN
     AVHVFEPYDD PSFSEEGKIT HISPQKMFEC ALDKHDKQGM FETFVTGWKF FMSVEDVSRK
     CIEEKQKELE LLEKGEKMTQ FQVERKSRLE RLVCCFSEFV DKFPGEIGSA MMKYFATEDS
     TEVMKNSVIR AVKGAQKEEE KSLLHTSYPF LPELKSPEKA SFKKRSLSGN KKTEKVMSAS
     SSPISSVQNS PRQRPCSDEM VQDVNYDNFV LLDPYLTARQ MIYYNREMLN NVSLAEFFDY
     KNSKAYEKYM KRLNSLTNVL DKIKLVSKAF EIFINIASSA MELNDFTVSY LVYKFIKDKL
     QLLELKLDKV IKKDFDELDF TFSCVKNYYN YRTKFQTICT TTAPRMPLLF VWENDMDALS
     NASHVDQVGQ IDLNQLKSQI DLVGIIDAAK TIPYSIDQNV SFQFFFHSNY F
//