ID A0A0A1UE96_ENTIV Unreviewed; 463 AA.
AC A0A0A1UE96;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Elongation factor 1-alpha {ECO:0000256|RuleBase:RU000325};
GN ORFNames=EIN_248230 {ECO:0000313|EMBL:ELP94859.1}, EIN_249840
GN {ECO:0000313|EMBL:ELP94910.1}, EIN_250900
GN {ECO:0000313|EMBL:ELP94956.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP94910.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP94910.1, ECO:0000313|Proteomes:UP000014680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP94910.1,
RC ECO:0000313|Proteomes:UP000014680};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-
CC tRNA to the A-site of ribosomes during protein biosynthesis.
CC {ECO:0000256|RuleBase:RU000325}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249,
CC ECO:0000256|RuleBase:RU000325}.
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DR EMBL; KB206169; ELP94859.1; -; Genomic_DNA.
DR EMBL; KB206169; ELP94910.1; -; Genomic_DNA.
DR EMBL; KB206169; ELP94956.1; -; Genomic_DNA.
DR RefSeq; XP_004261630.1; XM_004261582.1.
DR RefSeq; XP_004261681.1; XM_004261633.1.
DR RefSeq; XP_004261727.1; XM_004261679.1.
DR AlphaFoldDB; A0A0A1UE96; -.
DR EnsemblProtists; ELP94859; ELP94859; EIN_248230.
DR EnsemblProtists; ELP94910; ELP94910; EIN_249840.
DR EnsemblProtists; ELP94956; ELP94956; EIN_250900.
DR GeneID; 14893907; -.
DR GeneID; 14893954; -.
DR GeneID; 14894054; -.
DR KEGG; eiv:EIN_248230; -.
DR KEGG; eiv:EIN_249840; -.
DR KEGG; eiv:EIN_250900; -.
DR VEuPathDB; AmoebaDB:EIN_248230; -.
DR VEuPathDB; AmoebaDB:EIN_249840; -.
DR VEuPathDB; AmoebaDB:EIN_250900; -.
DR OrthoDB; 5477300at2759; -.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd03693; EF1_alpha_II; 1.
DR CDD; cd03705; EF1_alpha_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR HAMAP; MF_00118_A; EF_Tu_A; 1.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004539; Transl_elong_EF1A_euk/arc.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR NCBIfam; TIGR00483; EF-1_alpha; 1.
DR PANTHER; PTHR23115:SF170; ELONGATION FACTOR 1-ALPHA 2; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000256|RuleBase:RU000325,
KW ECO:0000313|EMBL:ELP94910.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000325};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000325};
KW Nucleotidyltransferase {ECO:0000313|EMBL:ELP94910.1};
KW Protein biosynthesis {ECO:0000256|RuleBase:RU000325,
KW ECO:0000313|EMBL:ELP94910.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000014680};
KW Transferase {ECO:0000313|EMBL:ELP94910.1}.
FT DOMAIN 5..228
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 463 AA; 50730 MW; 888FBB8B235A9B13 CRC64;
MPKEKVHINI VVIGHVDSGK STTTGHLIYK CGGIDKRVME KFEKESAEMG KGSFKYAWVL
DNLKAERERG ITIDISLWKF ESPKYYFTII DAPGHRDFIK NMITGTSQAD VAILVVAAGT
GEFEAGISKN GQTREHILLS YTLGIKQMIV AVNKMDTAKY SQARFEEIKK EISTFLKKTG
FNPDKIPFVP ISGFQGDNMI DQSTNMSWYK GPTLLGALDN VNEPVRPVEK PLRIPLQDVY
KISGIGTVPV GRVETGVLKP GMFLTFAPTG VTSECKSVEM HHVALTQAIP GDNVGFNVKN
LTVKDIKRGN VASDSKNKPA SKTEYFKAQV IIMNHPGQIR KGYTPVLDCH TSHIACKFFH
LEAKIDRRTG KAEEGVPEFV KNGDSAIIDI LPTKPLCVET FTEYPPLGRF AVRDMKQTVA
VGVVKAVFAP SDDATKFLQE HGEATKAAAK GGKAGAKAAP AKK
//
