ID A0A0A2ET86_9PORP Unreviewed; 459 AA.
AC A0A0A2ET86;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Methyltransferase {ECO:0000256|RuleBase:RU362026};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU362026};
GN ORFNames=HW49_05125 {ECO:0000313|EMBL:KGN80725.1};
OS Porphyromonadaceae bacterium COT-184 OH4590.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae.
OX NCBI_TaxID=1517682 {ECO:0000313|EMBL:KGN80725.1, ECO:0000313|Proteomes:UP000030107};
RN [1] {ECO:0000313|EMBL:KGN80725.1, ECO:0000313|Proteomes:UP000030107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COT-184 OH4590 {ECO:0000313|Proteomes:UP000030107};
RA Wallis C., Deusch O., O'Flynn C., Davis I., Jospin G., Darling A.E.,
RA Coil D.A., Alexiev A., Horsfall A., Kirkwood N., Harris S., Eisen J.A.;
RT "Porphyromonadaceae COT-184_OH4590 Genome sequencing.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:16857, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:13674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:137933; EC=2.1.1.113;
CC Evidence={ECO:0000256|ARBA:ARBA00001893};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family. N(4)
CC subfamily. {ECO:0000256|ARBA:ARBA00010203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGN80725.1}.
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DR EMBL; JRAN01000034; KGN80725.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A2ET86; -.
DR REBASE; 111152; M.Psp4590ORF5125P.
DR eggNOG; COG0863; Bacteria.
DR OrthoDB; 9800801at2; -.
DR Proteomes; UP000030107; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR017985; MeTrfase_CN4_CS.
DR InterPro; IPR001091; RM_Methyltransferase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12697:SF5; DEOXYHYPUSINE HYDROXYLASE; 1.
DR PANTHER; PTHR12697; PBS LYASE HEAT-LIKE PROTEIN; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR PRINTS; PR00508; S21N4MTFRASE.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00093; N4_MTASE; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000313|EMBL:KGN80725.1};
KW Hydrolase {ECO:0000313|EMBL:KGN80725.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nuclease {ECO:0000313|EMBL:KGN80725.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030107};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 206..433
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 459 AA; 53975 MW; 2EF3BB2A77DEC3FD CRC64;
MLTKEYIKEI KLANTEGLKQ LIHKNMNNSG NLVFILENLG KLPVSFNYHW LVDLINYDNE
QVRFWVVKNL GKLKSENIIN HLENISKNDK STLVRREAIS SIGRLRDEKN QQVLLGNLLD
EDPKIVSQAI RGLLVFKGDK KIDIALKELI NHENEMVRSV IYKEYFAQEK KKKSILPHPE
TYSFLKNVVV NGDVRDVLKN VPDESIHLTF TSPPYYNARD YSIYPSYDAY LHFLEEVFQE
TYRVTKEGRF LIVNTSPVIV PRISRAHSSK RYPIPFDIHH FLVQMGWEFI DDIIWQKPEY
SVKNRIGGFQ QHRKPLAYKP NTTTEYLMVY RKQTEKLIDW NIKQYSKEIV EESKVADGFE
TTNVWQIHPK SDKIHSAIFP VDLCKRVVEY YSFKGDLIFD PFGGSGTLGR TAKSLGRNFF
LTEKEPRYFE YMKTFQKKDI FQDHSTKFFT LDEFKKSIL
//
