ID A0A0A2L647_PENIT Unreviewed; 435 AA.
AC A0A0A2L647;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=catechol O-methyltransferase {ECO:0000256|ARBA:ARBA00012880};
DE EC=2.1.1.6 {ECO:0000256|ARBA:ARBA00012880};
GN ORFNames=PITC_098650 {ECO:0000313|EMBL:KGO75582.1};
OS Penicillium italicum (Blue mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=40296 {ECO:0000313|EMBL:KGO75582.1, ECO:0000313|Proteomes:UP000030104};
RN [1] {ECO:0000313|EMBL:KGO75582.1, ECO:0000313|Proteomes:UP000030104}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHI-1 {ECO:0000313|EMBL:KGO75582.1,
RC ECO:0000313|Proteomes:UP000030104};
RX PubMed=25338147; DOI=10.1094/MPMI-09-14-0261-FI;
RA Ballester A.R., Marcet-Houben M., Levin E., Sela N., Selma-Lazaro C.,
RA Carmona L., Wisniewski M., Droby S., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome, transcriptome, and functional analyses of Penicillium expansum
RT provide new insights into secondary metabolism and pathogenicity.";
RL Mol. Plant Microbe Interact. 28:232-248(2015).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Cation-dependent O-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00023453}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGO75582.1}.
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DR EMBL; JQGA01000456; KGO75582.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A2L647; -.
DR STRING; 40296.A0A0A2L647; -.
DR HOGENOM; CLU_630217_0_0_1; -.
DR OrthoDB; 4040098at2759; -.
DR PhylomeDB; A0A0A2L647; -.
DR Proteomes; UP000030104; Unassembled WGS sequence.
DR GO; GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006584; P:catecholamine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002935; SAM_O-MeTrfase.
DR PANTHER; PTHR43836; CATECHOL O-METHYLTRANSFERASE 1-RELATED; 1.
DR PANTHER; PTHR43836:SF2; CATECHOL O-METHYLTRANSFERASE 1-RELATED; 1.
DR Pfam; PF13578; Methyltransf_24; 1.
DR SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51682; SAM_OMT_I; 1.
PE 3: Inferred from homology;
KW Catecholamine metabolism {ECO:0000256|ARBA:ARBA00022939};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KGO75582.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030104};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KGO75582.1}.
SQ SEQUENCE 435 AA; 49100 MW; 28C5FA163FAFC342 CRC64;
MAEPEIFTKY PSLKKMEGLN DEDIVESHDG REVTLLKYIY NHPDLDTKLR GSPSAILAAM
DEFASQEDFL INIGSDKAQK LTDLVREYRP RVVVELGGYV GYSAILFGYI LKEIDEQHKP
ELEEGEKSAS SKLKIYSVEI DPLIASVAMN LVSLAGLQDI VEVIVGASAH TLQRFHDEGI
LAKTGIDLLF LDHDEALYEP DVKLAEKLGF LDKEDTVVIA DNVVRPGAPE YRSYMRQNPR
LSQSWGLAGL IVPGDFECGW RAKKMGLKGI SKKLGQPVEE NRIGYAGMDA RMELIIGRHP
IGTGKGFLLA GQLLLADCQE IRGIWEEVQM ARVYFVEVLH MHLRWYRRRA EENLVIFHCD
DIDAVPVVNV SPKNIDTVIV DGKIVKQNDR LVGVDWEFLR DQMICRSQRL TEQAKVEMEK
AESLFHSIFE KAVET
//
