ID A0A0A2LBN3_PENIT Unreviewed; 1672 AA.
AC A0A0A2LBN3;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=PITC_091210 {ECO:0000313|EMBL:KGO76598.1};
OS Penicillium italicum (Blue mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=40296 {ECO:0000313|EMBL:KGO76598.1, ECO:0000313|Proteomes:UP000030104};
RN [1] {ECO:0000313|EMBL:KGO76598.1, ECO:0000313|Proteomes:UP000030104}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHI-1 {ECO:0000313|EMBL:KGO76598.1,
RC ECO:0000313|Proteomes:UP000030104};
RX PubMed=25338147; DOI=10.1094/MPMI-09-14-0261-FI;
RA Ballester A.R., Marcet-Houben M., Levin E., Sela N., Selma-Lazaro C.,
RA Carmona L., Wisniewski M., Droby S., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome, transcriptome, and functional analyses of Penicillium expansum
RT provide new insights into secondary metabolism and pathogenicity.";
RL Mol. Plant Microbe Interact. 28:232-248(2015).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGO76598.1}.
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DR EMBL; JQGA01000240; KGO76598.1; -; Genomic_DNA.
DR STRING; 40296.A0A0A2LBN3; -.
DR HOGENOM; CLU_000487_2_2_1; -.
DR OMA; NREDYQQ; -.
DR OrthoDB; 169836at2759; -.
DR PhylomeDB; A0A0A2LBN3; -.
DR Proteomes; UP000030104; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02735; RNAP_I_Rpa1_C; 1.
DR CDD; cd01435; RNAP_I_RPA1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 1.10.357.120; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.70.2850; -; 2.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR047107; DNA-dir_RNA_pol1_lsu_C.
DR InterPro; IPR015699; DNA-dir_RNA_pol1_lsu_N.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF11; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030104};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 349..676
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 146..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1329..1456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1418..1433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1672 AA; 184974 MW; C356F488AFC59553 CRC64;
MATFARPVAS TINGVDFNVY SEEEIKALSV KRIHNTPTLD SFNNPVPGGL QDPAMGAWGD
HVCTTCRQNS FTCTGHPGHI ELPVPFYNVT FFDHIFRLLR AQCVYCLRLQ MGRNQVNMYT
CKLRLLQYGL VDEVAIVDAM GAVKGAKSKP TKGKEDDSDD SDDPDDDDYM QKRTDYVTRR
IREAKKEGKL DGLMPGGQNP IAAEARRELL KAFFKDVNGF KKCVNCSGVS PAYKKDRYNK
IFRKQLPEKQ KLAMLQGGFQ APNTMVLLDQ ERNSKSKNGV SEIHGAEEEI RRGVAVMQEV
QGSSTGQEFM SSSEVYGALH LLFQKESEIL QLVYNSRPVP KGVPVVSADM FFIKSLMVPP
NKYRPAVQQG AGTVMEAQQN TSFNAILKGC DTINQISKEI QNEEEKTMSR ARNYSDLLQA
IVQLQDVVNG LIDRDRTSVT GSAAAAQPNG IKQVLEKKEG LFRKNMMGKR VNFAARSVIS
PDPNIEPNEI GVPLVFAKKL TFPEPVTNHN FWELKEAVIN GPDKYPGASS IENENGQVIN
LKFKNLEERT ALANQLLAPS NWRQKGSRNK KVYRHLTTGD YVLMNRQPTL HKPSIMGHKA
RVLPNERVIR MHYANCNTYN ADFDGDEMNM HFPQNELAQA EARMLADADH QYLVATSGKP
LRGLIQDHIS MGTWVTCRDS FYDEEDYHQL LYSCLRPEHS HIVTDRIQLV EPAMRKPKCL
WTGKQIITTI LKNIQPPERG GLTLKSKSST PGDRWGEGNE EGEVIFQDGE YLCGILDKKQ
LGPTAGGLID AIHEVYGYST AGKLIGVLGR LLTRVLNLRG FSCGIDDLRL TKEGDRIRKE
KLATAPQMGR EVALKYVTLD KAPGDQTAEL NRRLEEVLRD DDKQSGLDSV SNARSAKLSS
EITSACLPHG LAKPFPWNQM QSMTISGAKG SGVNANLISC NLGQQVLEGR RVPLMISGKT
LPSFKAFETH PMAGGYVSGR FLTGIKPQEY YFHAMAGREG LIDTAVKTSR SGYLQRCLIK
GMEGLKAEYD SSVREASDGS IVQFLYGEDG LDITKQVHLN DFDFLAQNHI SISKQVQADD
YHKLAKDNVT TWHKDAMKAV RKTGKIDAVD PVLSHFPPGG NLGSTSEAFA QELKKYADAN
KNKLIKDKKK NIEGKVTKKT FEALMNMKYM KSIIDPGEAV GIMAGQSVGE PSTQMTLNTF
HLAGHSAKNV TLGIPRLREI VMTASAKIMT PTMTLLLNEE ISNDDSEKFA KAISKLSIAE
LVDKVQVKER IGTGIGHAKA KIYDIEINFF PSEEYTKEYA IETKDVLVAL QSKLIPRLVR
LTKAELKKRN EEKKGVKGTT SQPEIGVSVG KIAEAPRGAD SEAQPADDDN EDDEDDAKRA
AGAQNRGNQV SYEGPDAGEQ DIIRRQDTPD EDEDEDESSK PAKATRDVEM KDGSDSDSED
ESDDETVQDS KAREEDVMGK FEEITKFKFD PKNGNTCLIQ LQYDVETPKL LLLPLVEKVL
HLAVIQCIPG MGNCVFVEAD EAKGDPANIL TEGVNLLAMR DYQDIIKPHS IYTNSIHDML
NLYGVEAARA TIVREMDAVF KGHSISVDNR HLNLIGDVMT QSGGFKAFSR NGLVKDASSA
FARASFETTV GALKDVVLER GVDNLKSPSA RIVVGRVGTV GTGSFDILAP VA
//
