ID A0A0A2VFB5_BEABA Unreviewed; 611 AA.
AC A0A0A2VFB5;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Probable lysosomal cobalamin transporter {ECO:0000256|ARBA:ARBA00017088};
GN ORFNames=BBAD15_g8446 {ECO:0000313|EMBL:KGQ06238.1};
OS Beauveria bassiana D1-5.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=1245745 {ECO:0000313|EMBL:KGQ06238.1, ECO:0000313|Proteomes:UP000030106};
RN [1] {ECO:0000313|EMBL:KGQ06238.1, ECO:0000313|Proteomes:UP000030106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D1-5 {ECO:0000313|EMBL:KGQ06238.1,
RC ECO:0000313|Proteomes:UP000030106};
RA Li Q., Wang L., Zhang Z., Wang Q., Ren J., Wang M., Xu W., Wang J., Lu Y.,
RA Du Q., Sun Z.;
RT "Genome sequencing and analysis of entomopathogenic fungi Beauveria
RT bassiana D1-5.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC cobalamin from lysosomes allowing its conversion to cofactors.
CC {ECO:0000256|ARBA:ARBA00025515}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC {ECO:0000256|ARBA:ARBA00009901}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGQ06238.1}.
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DR EMBL; ANFO01000847; KGQ06238.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A2VFB5; -.
DR STRING; 1245745.A0A0A2VFB5; -.
DR eggNOG; ENOG502QQ2T; Eukaryota.
DR HOGENOM; CLU_028341_1_0_1; -.
DR Proteomes; UP000030106; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR PANTHER; PTHR16130:SF2; LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1; 1.
DR PANTHER; PTHR16130; LYSOSOMAL COBALAMIN TRANSPORTER-RELATED; 1.
DR Pfam; PF04791; LMBR1; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030106};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 582..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 67519 MW; C51FAEAD8290A0AE CRC64;
MLADAGLIQT SLIWVAYACA VAFCLIAAII TTFTWQTPRE RSAVVSAVAV VSLTALLATV
LLLPVDIALV SATGSARLGV KKHWATPERV ADILLSLKVL YYTLYSVDAL LCLLLIPFAY
FWYEEYDEIE FEEEGRTWRS RLWAATKYTL FFVALVVALF LIGFFVPAAG GRGGGPGKDW
ANLASSYLDS LVSQSNGEKA LTFALGLLVT LGTLLYVVYT GAGLALMPIS FIKSAPSISA
PQLSATTASQ LAQNRERQRQ LEMRYAGRHD DSMTRKDRRE LDALVREEQT LVRRERLAAE
AQGEGHSRLY HAWLQVCAFF RPVKMIGGIL LLLLSVLVAI SMLITGIDKA THSVCKQRCG
YVLDRIRVFQ PINWIFVQTA RVFPIDYVLM ALLVLHLFSS SISGIAAVGI RFLWIRIFQI
RRGRTAPQAL LIATVMLGLI TLAVNYAVAM FVAPQYSVFG TQTFCSLDPP APGMSPDCRA
NPDKVLPCAH SLEHPFAARA CTPSVMSTFL NRITTTWPFF GIVTFWGQFV FLAVFLVVLV
TALFRAPRVN LTELDEDAEE DEEESLLAAT GRRFAASWED ARGNISNTGN NNNNNNNNNN
RNSRNYGTSH A
//
