ID A0A0A2VKU3_BEABA Unreviewed; 4326 AA.
AC A0A0A2VKU3;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=BBAD15_g6470 {ECO:0000313|EMBL:KGQ08193.1};
OS Beauveria bassiana D1-5.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=1245745 {ECO:0000313|EMBL:KGQ08193.1, ECO:0000313|Proteomes:UP000030106};
RN [1] {ECO:0000313|EMBL:KGQ08193.1, ECO:0000313|Proteomes:UP000030106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D1-5 {ECO:0000313|EMBL:KGQ08193.1,
RC ECO:0000313|Proteomes:UP000030106};
RA Li Q., Wang L., Zhang Z., Wang Q., Ren J., Wang M., Xu W., Wang J., Lu Y.,
RA Du Q., Sun Z.;
RT "Genome sequencing and analysis of entomopathogenic fungi Beauveria
RT bassiana D1-5.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGQ08193.1}.
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DR EMBL; ANFO01000603; KGQ08193.1; -; Genomic_DNA.
DR STRING; 1245745.A0A0A2VKU3; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_7_0_1; -.
DR Proteomes; UP000030106; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030106}.
FT DOMAIN 1918..2056
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2573..2727
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2915..3081
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1618..1645
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3177..3239
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3403..3444
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4326 AA; 489847 MW; 987594967F166A9B CRC64;
MEVSSPPPPG LTSNGLSSPA PFPTIEPERV LDHLVAVCQV ALGASKEELE QPGNLLSSSR
HAETVARCTR FATENQNVLY IQKDVATSSA VDAGSDIAVP SSFHYTLTTE ITSSATTVAS
LVLLKSPQPI DPTRSLTSQI FITNMPGPAA LNAAVGEQGT SISPWEVLHS QVHHALVPYF
DANTKSQLAA NGLRGRADVD AKTGIPVTKK RLNDLELSLL HLQQNVDIPE ISLTFHSIVQ
NALEEAEARH GRPSIDSIPP TLLQDSTFLN RLQANVNTWI KSIQGVTKMT KDPSSPTNQE
FSTASQEVNF WLSMESALEG IEGQLRSEGV LLTLEILKHA KRFQATVSFT ADTGLKEAMD
KVQKYNQLMR DFPLDELLSA TSLSKVQEAI SQIFNHLTKK LRICPYPIRR ALPLVEAISA
DLDDVLHRLL PGMELVNLDY QQFQTIMHTC DEIFHTNEKF IPIKIHKKHL ELESRINYVS
TFRDNHEQLQ RTIVNVLGPN ATIPGSTETT TTNGIVMEEM GDVDAVEEVQ QAWEALQNVD
LLDVTEQGKE RWVLAENLYN ERTTRVENSI IARLRDRLAT AKTANEMFRV FSKFNALFVR
PKIRGAIQEY QNQLMDHVKQ AINGLHERFK QQYGHSEAHA MAQLRDLPPV SGAIIWARQI
EFQLDGYMRK VEAVLGPEWT LHAEGHKLQE ESELFKHKLD TARIYEAWLA DVGRRKISIS
GQLFDIARVR SAGGILELAV NFDPQIITLF KETRNLTWQS YSVPHAITTV SKDAKRVYPY
AVSLMESVRT LSQTLRQISV MGEESVLLNG YRNDVYKLIA DGVPLRWESF INSHELFYTD
QRQTRALLPG ANDYGLSKNT ESKHGMFIRG FAAAVSVLQS KAVALSYIHT TVEQALKEFG
SCDYDSSAFQ SRLDTIQAAV DQLNLEQYVN LEFWVRDLNK KIQAALLDRL HSAIQSWVAA
FEEEIPEGTR RKPLAEDETK PMGPTMKRLV LEVAMRNQVI YLDPPMEYAR ASWFLHLHEW
LGIVCNLRKI KAARYQMSLN TTMTDEPRFT DLPTECADTL QRVYVSVEKK LQEISAYVDK
WLQFQSLWDL QSEQVYDMLG DHLPRWLECL QDIRKVRTTF DTQEVSRSFG HLTIDYDQVQ
TKVNAKYDQW QQEILIKFAG RLGTRMREVN ADIEKARKSL EGQSSDTSST AQAVQFITAV
QTCKRNMKLW APEIDMFRQG QSTLVRQRYH FPNDWLHIEQ IDSQWEALKE ILEKKSRVME
EQSDAMRANI IAQDKLVSGR IAEIVAQWNE DKPVSGTIQP DIASATLSGF ETRISAIQED
LQQVIKAKEA LDLPGFADTS LEATLEEVRD FQSVWSNLST IWANLNETRE ILWTAVQPRK
IRSKVDDLIK STKEMPSRMR QYAAFEHVQG ILRGFLKVNP ILSDLKSDAI RERHWHKIYK
QIKPQKRFSP SSMTLGDVWD LNLVATEAIV KDIIAQAQGE MALEEFLKQV RETWQNYALE
MVNYQNKCRL IRGWDDLFAK CSENLNSLQA MKHSPYYKEF EEEAVAWEDK LNRVHVLFDV
WIDVQRQWVY LEGVFTGNAD IKHLLPIESG RFQNINSEFL AVMKKANKTP YVLDVLNIPN
AQKSLERLAE MLNKIQKALG EYLEKERVSF PRFYFVGDED LLEMIGNSND TLRIAKHFKK
MFAGLSGLVM DDETIISGYT SKEGEVVKLK KEISLAQTPR INDWLALLEG GMKTSLAELL
SEAVDQYTPL LQSSTIDAAA LRNYMEEFPS QIVVLASQAV WTTVVEESLA NGGQTLSDIF
EREVQILRVL ADTVLEELPV ILRKKCEQMI TECVHQRDVI EKLVAAKADS PTHYLWQLQM
RYIYTPQGPA LERLHIKMAN AKLNYGFEYL GVPDRLVRTP LTDRCFLTLT QALCQRLGGS
PYGPAGTGKT ESVKALGVQL GRFTLVFCCD DTFDFQAMGR IFLGICQVGA WGCFDEFNRL
EERILSAVSQ QIQNIQLGLK RGGENDDSQI DLIGRQLRVN ENTGIFITMN PGYAGRSNLP
DNLKKLFRSV AMSKPDKELI AEVMLYSQGF NQAKKLSKQA VPFFDMCAKQ LSKQAHYDFG
LRALKSVLVS SGGLKRARIT DSNIGTGEVV EPEIIVQSVR ETIAPKLIKS DVDIMTKIEG
ECFPGVQYVP ANLHALEEAI RAIAAERHLV VTDIWMTKVL QLYQIQNIHH GVMMVGNSGS
GKSAGWRLLL DALQRVEGIE GVSHVIDSKV MSKESLYGNL DSTTREWTDG LFTSILRKIV
DNLRGEDSKR HWIVFDGDVD PEWVENLNSV LDDNKLLTLP NGERLNLPSN VRIMFEVETL
KYATLATVSR CGMVWFSEET VTPSMVITNY LESLRNVPFE DLDEDNVATG QSAAKTLAVQ
SQAADLLQGY LEGDDFVMQA LEKSEKYNHI MEFTVARVLT TLFSLLNKAV RDMIEYNGQH
SDFPLELEQI EAFLPKRLLL ALVWAFTGDC PLNDRKSFGD EICAFANFGS PPLDGSSSLI
DFDVNLPKAE WNSWQTQVPT IEVNTHSIIQ TDVVIPTLDT VRHEDVLYSW LAEHKPLLLC
GPPGSGKTMT LFSALRKLPN MEVVGLNFSS ATTPDLLIKT FEQYCEYKKT LNGVVLSPTQ
IGRWLVVFCD EINLPAPDKY GTQRAISFLR QLVEHNGFWR TSDKSWVTLD RIQFVGACNP
PTDAGRTPMG ARFLRHAPLI MVDYPGELSL NQIYGTFNSA VLKIIPALRG YAEPLTQSMV
RFYLESQKRF TRSIQPHYVY SPRELTRWVR GVYEAIKPLE ILSIEGLVRI WAHEALRLFQ
DRLVAEDERK WTEESVHKIA LQYFPTIDEE KALGGPLLFS NWLSKNYIPV DREQLREFVK
ARLKAFCEEE VDVPLILFND VLEHVLRIDR VFRQPQGHLI LIGVSGSGKT TLSRFVAWMN
GLKVFQIKVH GKYSAEDFDD DLREVLRRCG CKGEKICFIM DEANVLDSGF LERMNTLLAN
AEVPGLFEGD EYAALMTACK EGAQRQNLHL DSPEELYKWF TQQIVNNLHV VFTMNPPEDG
LSSKAATSPA LFNRCVLNWF GDWSDQALFQ VGHELTQSID LDKSNWSAPD TVPVAYRGLN
MPPSHRETIV NSMVYIHYSL ARYNEKLYKQ QKKITFLTPR HFLDFVGQYV KLYTEKREDL
EEQQRHLNVG LEKLRDTVVK VRDLRVSLAE KKAQLEQKDA EANEKLQRMV ADQREAEQRK
NTSLEIQASL ERQEAEVASR RKVVLEDLDK AEPAVEEARA SVSNIKRQHL TEVRSMSNPP
QGVKLALDAV CTLLGHKIND WKAVQAIIRK DDFIASILMF DNAKMMTKAV RQKMRNEFLS
IPDFTFEKVN RASKACGPLV QWVAAQVNYS DILDRVGPLK EEVTQLEEQA LQTKANAKAV
ENNIAELESS INTYKTEYAA LISETQAIKA EMSKVQFKVD RSVRLLDSLS SERTRWEEGS
KSFETQISTL VGDVLVAAAF LAYSGLYDQQ FRKSMMDDWL HQLYLSGIQY KSPNPVTEYL
SSADERLGWQ ENSLPVDDLC TENAIILKRF NRYPLIIDPS GRVTEFLQKE CKDRRLTVTS
FLDDTFTKQL ESSLRFGNPI LIQDAEHLDP ILNHVLNKEY QRTGGRVLIQ LGKQEIDFSP
AFKLYLSTRD PSATFAPDIC SRTTFVNFTV TQSSLQTQSL NDVLKSERPD VDERRSNLIK
LQGEFKVHLR QLEKQLLQAL NESRGNILDD DNVIETLETL KREAAEISAK MSNTEGVMAE
VEEITQQYSV IARACSAVFA VLENLHYLNH FYQFSLQYFL DIFQSVLHNN QSLANVTTHN
ERRDIIVKDL FVNTFKRTAL GLLQKDRVAL ALLLAQATPY KMDKSLLDMV LDKRFEGRDL
SSNPDARDDA FIEARKIGAL KELLDGVAVS DWDKFFTEEL AENAVPKVWS DSANGMDQAL
LALLLVKCFR MDRFVPCAER FVAQVFGAET FDIVEDLKNT AMQVSATLPV ALVSTPGFDA
SYKVDNLVER VGVKCTNIAM GSNEGLASAD KAIAGAAETG SWVLVKNVHL APTWLQSLEK
RMESLNPHKD FRLFLSMESS PKIPVNLLRA SRVLMYEQPA GIRANMKDSM SSLSTRATKS
PVERARLYLL ISFLHAVVQE RLRYAPTLGW KGFWEFNDSD YECSAFIIDT WLDTVAGNRT
NIAPQNIPWD MICYLVTETY GGKVDDEADF ALLRQLVHQM LTAAAYDADH KLVDGPDGGL
TVPSGTSLQE FVAWVHNLPE REPPTYLGLP ANAEKLLLGG LGRSLVENVR SVTEILDEGE
QLMADG
//
